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TMEM173 / STING
transmembrane protein 173
Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. Essential for the induction of IFN-beta in response to human herpes simplex virus 1 (HHV-1) infection.
| Gene Name: | transmembrane protein 173 |
| Synonyms: | TMEM173, ERIS, MITA, HSTING, Transmembrane protein 173, HMITA, Mediator of IRF3 activation, MPYS, NET23, STING |
| Target Sequences: | Q86WV6 Q86WV6 |
Publications (7)
1
Cytoplasmic isoforms of Kaposi sarcoma herpesvirus LANA recruit and antagonize the innate immune DNA sensor cGAS. Zhang G, Chan B, Samarina N, Abere B, Weidner-Glunde M, Buch A, Pich A, Brinkmann MM, Schulz TF. Proceedings of the National Academy of Sciences of the United States of America. 2016 113:E1034-43. (ICC; Human)
[Full Text Article]
[PubMed:26811480]
[PMC:PMC4776510]
Related Antibodies: LS-C108557.
2
Cytoplasmic chromatin triggers inflammation in senescence and cancer. Dou Z, Ghosh K, Vizioli MG, Zhu J, Sen P, Wangensteen KJ, Simithy J, Lan Y, Lin Y, Zhou Z, Capell BC, Xu C, Xu M, Kieckhaefer JE, Jiang T, Shoshkes-Carmel M, Tanim KMAA, Barber GN, Seykora JT, Millar SE, Kaestner KH, Garcia BA, Adams PD, Berger SL. Nature. 2017 October;550:402-406. (Human)
[Full Text Article]
[PubMed:28976970]
[PMC:PMC5850938]
3
An Alternative Splicing of Tupaia STING Modulated Anti-RNA Virus Responses by Targeting MDA5-LGP2 and IRF3. Ling Xu, Dandan Yu, Li Peng, Yong Wu, Yu Fan, Tianle Gu, Yu-Lin Yao, Jin Zhong, Xinwen Chen, Yong-Gang Yao. Journal of immunology (Baltimore, Md. : 1950). 2020 June;204:3191-3204. [Full Text Article]
[PubMed:32376647]
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TMEM173 / STING Rabbit anti-Human Polyclonal (aa311-340) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
200 µl/$460
TMEM173 / STING Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ICC, IF, WB
Unconjugated
0.1 mg/$460
TMEM173 / STING Mouse anti-Human Monoclonal (1A7) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
TMEM173 / STING Mouse anti-Human Monoclonal (4E12) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
TMEM173 / STING Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
TMEM173 / STING Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IP, WB
Unconjugated
100 µl/$299
E. coli
His, N-Terminal
28.2 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$792
HEK 293 Cells
Myc-DDK (Flag)
42 kDa
20 µg/$1,107
E. coli
His, N-Terminal
27.8 kDa
10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148
E. coli
His-T7
26.9 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
TMEM173 / STING Mouse anti-Human Monoclonal (OTI4H1) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$450
TMEM173 / STING Mouse anti-Human Monoclonal (OTI3B10) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
TMEM173 / STING Rabbit anti-Human Polyclonal (aa284-316) Antibody
Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
TMEM173 / STING Rabbit anti-Human Polyclonal (aa216-265) Antibody
Human
WB
Unconjugated
100 µl/$424
TMEM173 / STING Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
TMEM173 / STING Rabbit anti-Human Polyclonal (aa311-340) (FITC) Antibody
Human
ELISA, Flo, IHC, WB
FITC Conjugated
200 µl/$952
TMEM173 / STING Rabbit anti-Human Polyclonal (aa311-340) (APC) Antibody
Human
ELISA, Flo, WB
APC Conjugated
200 µl/$952
TMEM173 / STING Rabbit anti-Human Polyclonal (aa311-340) (Azide-free) (HRP) Antibody
Human
ELISA, Flo, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
TMEM173 / STING Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC-P, WB
Unconjugated
50 µg/$460
TMEM173 / STING Rabbit anti-Human Polyclonal (aa310-360) Antibody
Mouse, Rat, Human, Monkey
IF
Unconjugated
100 µg/$386
TMEM173 / STING Rabbit anti-Mouse Polyclonal (aa160-371) Antibody
Mouse
WB
Unconjugated
100 µl/$321; 200 µl/$369; 500 µl/$527; 1 ml/$611; 2 ml/$842; 5 ml/$1,387
TMEM173 / STING Rabbit anti-Mouse Polyclonal (aa160-371) (APC) Antibody
Mouse
WB
APC Conjugated
100 µl/$432; 200 µl/$527; 500 µl/$934; 1 ml/$1,104; 2 ml/$1,479; 5 ml/$2,773
TMEM173 / STING Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
TMEM173 / STING Rabbit anti-Human Polyclonal (aa159-373) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$318; 200 µl/$364; 500 µl/$518; 1 ml/$595; 2 ml/$822; 5 ml/$1,345
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