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Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
STING antibody LS-C108557 is an unconjugated rabbit polyclonal antibody to STING (TMEM173) from human. It is reactive with human and mouse. Validated for ICC, IF and WB. Cited in 3 publications.
Human, Mouse
(tested or 100% immunogen sequence identity)
Clonality
IgGPolyclonal
Conjugations
Unconjugated
Purification
Peptide Column Affinity Chromatography
Modifications
Unmodified
Immunogen
A 17 AA synthetic peptide near the C-Terminus of human MPYS. The immunogen is located within aa 260-310 of MPYS.
Applications
ICC
Immunofluorescence
Western blot (1 - 2 µg/ml)
Failed Applications
IHC - Paraffin
Usage
MPYS antibody can be used for detection of MPYS by Western blot at 1 ug/mL. Antibody can also be used for immunocytochemistry starting at 5 ug/mL. For immunofluorescence start at 20 ug/mL. Antibody validated: Western Blot in human samples; Immunocytochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. Western Blot: Predicted: 31, 42 kDa Observed: 32 kDa
Presentation
PBS containing 0.02% Sodium Azide
Storage
Store at 4°C for up to 1 year.
Restrictions
For research use only. Intended for use by laboratory professionals.
The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response. Parvatiyar K, Zhang Z, Teles RM, Ouyang S, Jiang Y, Iyer SS, Zaver SA, Schenk M, Zeng S, Zhong W, Liu ZJ, Modlin RL, Liu YJ, Cheng G. Nature immunology. 2012 Dec;13:1155-61.
The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells. Zhang Z, Yuan B, Bao M, Lu N, Kim T, Liu YJ. Nature immunology. 2011 Oct;12:959-65.
Cytoplasmic isoforms of Kaposi sarcoma herpesvirus LANA recruit and antagonize the innate immune DNA sensor cGAS. Zhang G, Chan B, Samarina N, Abere B, Weidner-Glunde M, Buch A, Pich A, Brinkmann MM, Schulz TF. Proceedings of the National Academy of Sciences of the United States of America. 2016 113:E1034-43. (ICC; Human)