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TLR8
toll-like receptor 8
Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors. Like TLR7, TLR8 is localized to endosomal or lysosomal compartments and stimulates the innate immune response after activation by guanosine- and uridine-rich single-stranded RNA. Human but not murine TLR8 confers responsiveness to the antiviral compound R-848. The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X.
| Gene Name: | toll-like receptor 8 |
| Family/Subfamily: | Toll-like Receptor , not assigned-Toll-like Receptor |
| Synonyms: | TLR8, CD288, Toll-like receptor 8, CD288 antigen |
| Target Sequences: | NM_138636 NP_619542.1 Q9NR97 |
Publications (3)
1
TLR7 in B cells promotes renal inflammation and Gd-IgA1 synthesis in IgA nephropathy. Nuoyan Zheng, Kaifeng Xie, Hongjian Ye, Yu Dong, Bing Wang, Ning Luo, Jinjin Fan, Jiaqing Tan, Wei Chen, Xueqing Yu. JCI insight. 2020 July;5: [Full Text Article]
[PubMed:32699192]
[PMC:PMC7453916]
Related Antibodies: LS-B1421.
2
Human endogenous retrovirus HERV-K(HML-2) RNA causes neurodegeneration through Toll-like receptors. Paul Dembny, Andrew G Newman, Manvendra Singh, Michael Hinz, Michal Szczepek, Christina Krüger, Robert Adalbert, Omar Dzaye, Thorsten Trimbuch, Thomas Wallach, Gunnar Kleinau, Katja Derkow, Bernhard C Richard, Carola Schipke, Claus Scheidereit, Harald Stachelscheid, Douglas Golenbock, Oliver Peters, Michael Coleman, Frank L Heppner, Patrick Scheerer, Victor Tarabykin, Klemens Ruprecht, Zsuzsanna Izsvák, Jens Mayer, Seija Lehnardt. JCI insight. 2020 April;5: [Full Text Article]
[PubMed:32271161]
[PMC:PMC7205273]
3
MicroRNA-100-5p and microRNA-298-5p released from apoptotic cortical neurons are endogenous Toll-like receptor 7/8 ligands that contribute to neurodegeneration. Thomas Wallach , Zoé J Mossmann , Michal Szczepek, Max Wetzel, Rui Machado, Martin Raden, Milad Miladi, Gunnar Kleinau, Christina Krüger, Paul Dembny, Drew Adler, Yuanyuan Zhai, Victor Kumbol, Omar Dzaye, Jutta Schüler, Matthias Futschik, Rolf Backofen, Patrick Scheerer, Seija Lehnardt. Molecular neurodegeneration. 2021 November;16:80. [Full Text Article]
[PubMed:34838071]
[PMC:PMC8626928]
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TLR8 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
TLR8 Mouse anti-Human Monoclonal (aa750-850) (44C143) Antibody
Mouse, Human
Flo, IHC, IHC-P, WB
Unconjugated
50 µg/$460
TLR8 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µg/$515
TLR8 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$460
TLR8 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
TLR8 Rabbit anti-Human Polyclonal (aa434-463) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
TLR8 Mouse anti-Human Monoclonal (aa750-850) (PE) (44C143) Antibody
Mouse, Human
Flo
PE Conjugated
0.1 ml/$416
Yeast
6His, N-terminus
93.4 kD
100 µg/$446; 20 µg/$336; 1 mg/$1,460
TLR8 Mouse anti-Human Monoclonal (PE) Antibody
Human
Flo, WB
PE Conjugated
100 µg/$815
TLR8 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$798
TLR8 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, IHC-P
Unconjugated
0.1 mg/$460
TLR8 Rabbit anti-Mouse Polyclonal (C-Terminus) Antibody
Mouse
ELISA, IHC, WB
Unconjugated
200 µl/$734
TLR8 Rabbit anti-Mouse Polyclonal (C-Terminus) (Biotin) Antibody
Mouse
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
TLR8 Rabbit anti-Mouse Polyclonal (C-Terminus) (FITC) Antibody
Mouse
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
TLR8 Rabbit anti-Mouse Polyclonal (C-Terminus) (Azide-free) (HRP) Antibody
Mouse
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
TLR8 Rabbit anti-Mouse Polyclonal (C-Terminus) (PE) Antibody
Mouse
ELISA, IHC, WB
PE Conjugated
200 µl/$952
TLR8 Rabbit anti-Mouse Polyclonal (C-Terminus) (APC) Antibody
Mouse
ELISA, IHC, WB
APC Conjugated
200 µl/$952
TLR8 Rabbit anti-Human Polyclonal (Internal) Antibody
Human
ICC, IHC, WB
Unconjugated
100 µg/$649
TLR8 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ICC, IF, WB
Unconjugated
50 µl/$286; 100 µl/$321; 200 µl/$386
Fast Shipping
TLR8 Rabbit anti-Human Polyclonal Antibody
IHC-P
Unconjugated
50 µg/$460
Fast Shipping
TLR8 Rabbit anti-Human Polyclonal Antibody
IHC-P
Unconjugated
50 µg/$460
TLR8 Mouse anti-Human Monoclonal (aa32-153) (OTI4F3) Antibody
Human
IHC, WB
Unconjugated
100 µl/$434
TLR8 Mouse anti-Human Monoclonal (aa32-153) (Carrier-free) (OTI4F3) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
TLR8 Mouse anti-Human Monoclonal (Azide-free) Antibody
Human
Flo, IHC
Unconjugated, Azide-free
100 µg/$414
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