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TLR4
toll-like receptor 4
Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni2+. Responses triggered by Ni2+ require non-conserved histidines and are, therefore, species-specific. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion.
| Gene Name: | toll-like receptor 4 |
| Family/Subfamily: | Toll-like Receptor , not assigned-Toll-like Receptor |
| Synonyms: | TLR4, CD284, CD284 antigen, Homolog of Drosophila toll, TLR-4, TOLL, ARMD10, Toll-like receptor 4, HToll |
| Target Sequences: | NM_138554 O00206 O00206 |
Publications (12)
1
High-mobility group box 1 activates integrin-dependent homing of endothelial progenitor cells. Chavakis E, Hain A, Vinci M, Carmona G, Bianchi ME, Vajkoczy P, Zeiher AM, Chavakis T, Dimmeler S. Circulation research. 2007 100:204-12.
[PubMed:17218606]
Related Antibodies: LS-C40824.
2
Altered Levels of Toll-Like Receptors in Circulating Extracellular Vesicles in Multiple Sclerosis. Bhargava P, Nogueras-Ortiz C, Chawla S, Bæk R, Jørgensen MM, Kapogiannis D. Cells. 2019 September;8:E1058. [Full Text Article]
[PubMed:31509962]
[PMC:PMC6769450]
3
Time course of microglia activation and brain and blood cytokine/chemokine levels following chronic ethanol exposure and protracted withdrawal in rats. Manuel Sanchez-Alavez, William Nguyen, Simone Mori, Derek N Wills, Dennis Otero, Cindy L Ehlers, Bruno Conti. Alcohol (Fayetteville, N.Y.). 2019 May;76:37-45. [Full Text Article]
[PubMed:30554034]
[PMC:PMC6336521]
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Neuroscience
TLR4 Mouse anti-Human Monoclonal (aa100-200) (76B357.1) Antibody
Mouse, Rat, Human
Flo, IHC, IHC-P, WB
Unconjugated
50 µg/$460
TLR4 Mouse anti-Human Monoclonal (1E11) Antibody
Human
ELISA, Flo, IHC, IHC-P
Unconjugated
50 µg/$485
Neuroscience
Fast Shipping
TLR4 Rabbit anti-Human Polyclonal (Internal) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
TLR4 Mouse anti-Human Monoclonal (HTA125) Antibody
Guinea pig, Human
Flo, IF, IHC, IHC-Fr
Unconjugated
100 µg/$339
TLR4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ICC, IHC, IHC-P, WB
Unconjugated
0.1 ml/$386
TLR4 Rabbit anti-Human Polyclonal (aa650-700) Antibody
Bovine, Horse, Macaque, Human
IHC, IHC-P, WB
Unconjugated
50 µg/$460
Neuroscience
TLR4 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$440
TLR4 Goat anti-Human Polyclonal (aa161-192) Antibody
Human
IHC, IHC-P, WB
Unconjugated
0.1 mg/$500
TLR4 Mouse anti-Human Monoclonal (FITC) (HTA125) Antibody
Human
Flo
FITC Conjugated
25 µg/$281; 0.1 mg/$432
TLR4 Rabbit anti-Human Polyclonal (aa418-435) Antibody
Mouse, Human, Monkey
ICC, IHC, IHC-Fr, WB
Unconjugated
0.1 mg/$386
TLR4 Rabbit anti-Mouse Polyclonal (aa400-450) Antibody
Mouse, Human
Flo, ICC, IF, IHC, IHC-P, WB
Unconjugated
0.1 ml/$386
TLR4 Rabbit anti-Human Polyclonal (aa421-470) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
TLR4 Mouse anti-Human Monoclonal (HTA125) Antibody
Human
Flo, ICC, IP, Neut
Unconjugated
0.1 mg/$386
Sandwich
96-Well Microplate
Human
0.41 - 100 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$635
Sandwich
96-Well Strip Plate
Pig
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
Sandwich CLIA
12 x 8-Well Microstrips
Human
62.5 - 4000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$863
Sandwich
96-Well Microplate
Rat
0.31 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
Sandwich
96-Well Microplate
Mouse
0.16 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
Yeast
6His, N-terminus
100 µg/$499; 20 µg/$364; 1 mg/$1,683
E. coli
His, N-Terminal
33.3 kDa
10 µg/$267; 50 µg/$352; 100 µg/$562; 200 µg/$702; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900
Sandwich
96-Well Strip Plate
Bovine
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
Sandwich
96-Well Strip Plate
Rat
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$587
Sandwich
96-Well Strip Plate
Mouse
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates
1 Plate/$764
![TLR4 Antibody - Immunohistochemistry-Paraffin: TLR4 Antibody (76B357.1) [Azide Free] - Human skin stained with TLR4 antibody (5 ug/ml), peroxidase-conjugate and DAB chromogen. This image was taken for the unmodified form of this product. Other forms have not been tested.](https://lsbio-7d62.kxcdn.com/image2/tlr4-antibody-aa100-200-clone-76b357.1-azide-free-ls-c367232/257496_5037759.jpg)
TLR4 Mouse anti-Human Monoclonal (aa100-200) (Azide-free) (76B357.1) Antibody
Mouse, Rat, Human
Flo, ICC, IF, IHC, IHC-P, WB
Unconjugated, Azide-free
0.1 mg/$386
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