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Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. Required for normal cell adhesion and cell migration.
Gene Name: | T-cell lymphoma invasion and metastasis 1 |
Synonyms: | TIAM1, TIAM-1 |
Target Sequences: | NM_003253 NP_003244.2 Q13009 |
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