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TFF3 / Trefoil Factor 3
trefoil factor 3 (intestinal)
Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. TFF3 is expressed in goblet cells of the intestines and colon. The TFF3 gene consists of 3 exons, with exon 2 encoding the trefoil domain. The TFF1, TFF2, and TFF3 genes are located within a 55 kb region, suggesting they evolved from a common ancestor by duplication.
| Gene Name: | trefoil factor 3 (intestinal) |
| Synonyms: | TFF3, HP1.B, Intestinal trefoil factor, HITF, ITF, TFI, p1B, Polypeptide P1.B, Trefoil factor 3, Trefoil factor 3 (intestinal) |
| Target Sequences: | NM_003226 |
Publications (2)
1
Hepatic GALE Regulates Whole-Body Glucose Homeostasis by Modulating Tff3 Expression. Zhu Y, Zhao S, Deng Y, Gordillo R, Ghaben AL, Shao M, Zhang F, Xu P, Li Y, Cao H, Zagnitko O, Scott DA, Gupta RK, Xing C, Zhang BB, Lin HV, Scherer PE. Diabetes. 2017 November;66:2789-2799. [Full Text Article]
[PubMed:28877911]
[PMC:PMC5652600]
2
A reinforcing HNF4-SMAD4 feed-forward module stabilizes enterocyte identity. Lei Chen, Natalie H Toke, Shirley Luo, Roshan P Vasoya, Robert L Fullem, Aditya Parthasarathy, Ansu O Perekatt, Michael P Verzi. Nature genetics. 2019 May;51:777-785. [Full Text Article]
[PubMed:30988513]
[PMC:PMC6650150]
Related Antibodies: LS-C662731.
☰ Filters
Products
Proteins
(20)
Type
Over-Expression Lysate
(2)
Recombinant
(18)
Target
TFF3 / Trefoil Factor 3
(20)
Publications
No
(20)
Tag
6His, N-terminus + Mouse IgG Fc, C-terminus
(1)
GST
(1)
His
(1)
His, C-Terminal
(1)
His, N-Terminal
(1)
His,C-terminus
(1)
His-GST
(4)
His-GST-S
(1)
His-MBP
(2)
Myc-DDK (Flag)
(2)
TRX-6His, N-terminus
(1)
Species
Bovine
(1)
Dog
(1)
Human
(8)
Mouse
(5)
Pig
(3)
Rat
(1)
Source
293T Cells
(1)
E. coli
(14)
HEK 293 Cells
(2)
Human
(1)
Mammalian Cells
(1)
Wheat Germ Extract
(1)
Purification
Purified
(7)
Low Endotoxin Level
Low endotoxin level
(5)
Biologically Active
Biologically active
(4)
E. coli
His-MBP
53.1 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
E. coli
His-MBP
53.1 kDa
10 µg/$288; 50 µg/$487; 100 µg/$780; 200 µg/$972; 1 mg/$2,109; 500 µg/$1,636; 5 mg/$3,403; 2 mg/$2,298
E. coli
None
Biologically active
13.2 kDa
5 µg/$282; 100 µg/$957; 500 µg/$1,747
E. coli
His-GST-S
36.5 kDa
10 µg/$287; 50 µg/$480; 100 µg/$767; 200 µg/$957; 1 mg/$2,089; 500 µg/$1,617; 5 mg/$3,347; 2 mg/$2,278
E. coli
His-GST
33.6 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
13.2 kDa
5 µg/$268; 20 µg/$349
E. coli
His, N-Terminal
53.1 kDa
10 µg/$288; 50 µg/$487; 100 µg/$780; 200 µg/$972; 1 mg/$2,109; 500 µg/$1,636; 5 mg/$3,403; 2 mg/$2,298
Wheat Germ Extract
GST
32.23 kDa
10 µg/$479; 25 µg/$670
Human
His, C-Terminal
Less than 1.0 EU/µg protein (determined by LAL method).
7.3kD
10 µg/$277; 50 µg/$376; 500 µg/$1,484; 1 mg/$2,157
293T Cells
Myc-DDK (Flag)
14.25 kDa
20 µg/$150
HEK 293 Cells
Myc-DDK (Flag)
14.25 kDa
100 µg/$494
E. coli
None
Biologically active
Less than 1 EU/µg (determined by LAL method).
6.6 kDa
1 mg/$2,653; 20 µg/$364
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
~6.8 kDa
20 µg/$291; 100 µg/$597; 1 mg/$2,551
Mammalian Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
7.3 kDa
10 µg/$277; 50 µg/$371
E. coli
TRX-6His, N-terminus
26.4 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365
HEK 293 Cells
6His, N-terminus + Mouse IgG Fc, C-terminus
37-45 kDa
100 µg/$432; 250 µg/$726; 500 µg/$1,270; 1000 µg/$1,799
E. coli
His-GST
33.5 kDa
10 µg/$288; 50 µg/$487; 100 µg/$780; 200 µg/$972; 1 mg/$2,109; 500 µg/$1,636; 5 mg/$3,403; 2 mg/$2,298
E. coli
His
5.9 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
E. coli
His-GST
38.5 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
E. coli
His-GST
40.3 kDa
10 µg/$279; 50 µg/$427; 100 µg/$682; 200 µg/$852; 1 mg/$1,950; 500 µg/$1,494; 5 mg/$2,983; 2 mg/$2,136
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