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TDP-43 / TARDBP

TAR DNA binding protein

DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR.

Gene Name: TAR DNA binding protein
Synonyms: TARDBP, ALS10, TAR DNA-binding protein-43, TDP-43, TAR DNA binding protein, TAR DNA-binding protein 43, TDP43
Target Sequences: NM_007375 NP_031401.1 Q13148

Publications (4)

1
Evidence of multisystem disorder in whole-brain map of pathological TDP-43 in amyotrophic lateral sclerosis. Geser F, Brandmeir NJ, Kwong LK, Martinez-Lage M, Elman L, McCluskey L, Xie SX, Lee VM, Trojanowski JQ. Archives of neurology. 2008 65:636-41. [PubMed:18474740]
2
TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration. Wegorzewska I, Bell S, Cairns NJ, Miller TM, Baloh RH. Proceedings of the National Academy of Sciences of the United States of America. 2009 106:18809-14. [PubMed:19833869] [PMC:PMC2762420]
3
Downregulation of VAPB expression in motor neurons derived from induced pluripotent stem cells of ALS8 patients. Mitne-Neto M, Machado-Costa M, Marchetto MC, Bengtson MH, Joazeiro CA, Tsuda H, Bellen HJ, Silva HC, Oliveira AS, Lazar M, Muotri AR, Zatz M. Human molecular genetics. 2011 20:3642-52. [PubMed:21685205] [PMC:PMC3159551]
4
TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes. Kawahara Y, Mieda-Sato A. Proceedings of the National Academy of Sciences of the United States of America. 2012 109:3347-52. [PubMed:22323604] [PMC:PMC3295278]
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Products
Antibodies (72)
Primary (72)
TDP-43 / TARDBP (72)
Human (63)
Mouse (47)
Rat (23)
Bat (12)
Bovine (13)
Chicken (14)
Chimpanzee (12)
Dog (12)
Gibbon (12)
Guinea pig (12)
Horse (12)
Monkey (12)
Orangutan (9)
Pig (10)
Primate (5)
Rabbit (9)
Xenopus (5)
Zebrafish (8)
IHC (43)
IHC-Fr (4)
IHC-P (25)
WB (70)
Flo (4)
ELISA (18)
ICC (2)
IF (17)
IP (7)
Peptide-ELISA (2)
RNAi (1)
RnaIP (1)
rabbit (64)
mouse (7)
goat (1)
Product Group
IHCPlus (6)
PathPlus Neuro (4)
IgG (39)
IgG1 (3)
IgG1,k (2)
IgG2a (2)
monoclonal mc (7)
polyclonal pc (65)
2E2-D3 (1)
3H8 (1)
7F9A6 (1)
K1B8 (1)
APC (1)
APC Conjugated (3)
Biotin Conjugated (8)
Cy3 Conjugated (2)
Cy7 Conjugated (1)
DY488 Conjugated (1)
DY550 Conjugated (1)
DY650 Conjugated (1)
FITC Conjugated (7)
HRP Conjugated (7)
PE Conjugated (3)
Unconjugated (38)
aa104-262 (15)
aa1-30 (7)
C-Terminus (6)
N-Terminus (4)
aa252-301 (4)
aa337-386 (4)
aa72-121 (4)
aa1-260 (2)
aa140-153 (1)
aa150-200 (1)
aa250-300 (1)
aa350-414 (1)
pSer403/404 (1)
No (72)
TDP-43 / TARDBP Antibody - Anti-TARDBP antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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TDP-43 / TARDBP Mouse anti-Human Monoclonal (2E2-D3) Antibody
Human
ELISA, IF, IHC, IHC-P, RNAi, WB
Unconjugated
50 µg/$460
TDP-43 / TARDBP Antibody - Anti-TARDBP antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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TDP-43 / TARDBP Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
TDP-43 / TARDBP Antibody - Anti-TARDBP antibody IHC of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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TDP-43 / TARDBP Mouse anti-Human Monoclonal (aa1-260) (K1B8) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$460
TDP-43 / TARDBP Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Neuroscience
TDP-43 / TARDBP Goat anti-Human Polyclonal (aa140-153) Antibody
Human
IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$460
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TDP-43 / TARDBP Rabbit anti-Mouse Polyclonal (C-Terminus) Antibody
Mouse
IHC, WB
Unconjugated
200 µl/$468
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TDP-43 / TARDBP Mouse anti-Human Monoclonal (pSer403/404) Antibody
Mouse, Human
ELISA, WB
Unconjugated
100 µg/$361
TDP-43 / TARDBP Antibody - Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
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TDP-43 / TARDBP Mouse anti-Human Monoclonal (3H8) Antibody
Mouse, Bovine, Rat, Pig, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
TDP-43 / TARDBP Antibody - Anti-TDP-43 / TARDBP antibody IHC staining of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Neuroscience
TDP-43 / TARDBP Rabbit anti-Human Polyclonal (aa1-30) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
200 µl/$440
TDP-43 / TARDBP Antibody - Anti-TARDBP antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TDP-43 / TARDBP Rabbit anti-Human Polyclonal (aa350-414) Antibody
Xenopus, Chicken, Zebrafish, Mouse, Primate, Human
IHC, IHC-P, WB
Unconjugated
0.1 ml/$460
TDP-43 / TARDBP Antibody - Anti-TARDBP antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TDP-43 / TARDBP Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Xenopus, Chicken, Zebrafish, Mouse, Primate, Human
IHC, IHC-P, WB
Biotin Conjugated
0.1 ml/$416
TDP-43 / TARDBP Antibody - Anti-TARDBP antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Neuroscience
TDP-43 / TARDBP Rabbit anti-Human Polyclonal (aa252-301) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
TDP-43 / TARDBP Antibody - Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Neuroscience
TDP-43 / TARDBP Rabbit anti-Human Polyclonal (aa337-386) Antibody
Human
IHC-Fr, IHC-P, WB
Unconjugated
50 µl/$460
TDP-43 / TARDBP Antibody - TARDBP antibody ARP38942_T100-NP_031401-TARDBP (TAR DNA binding protein) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human heart.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TDP-43 / TARDBP Rabbit anti-Human Polyclonal (aa337-386) (Biotin) Antibody
Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Horse, Bat, Gibbon, Orangutan, Chimpanzee, Human, Monkey
IHC, IHC-Fr, IHC-P, WB
Biotin Conjugated
100 µl/$442
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TDP-43 / TARDBP Mouse anti-Human Monoclonal Antibody
Human
ELISA, Flo, IHC, IP, WB
Unconjugated
100 µg/$371
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TDP-43 / TARDBP Mouse anti-Human Monoclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100 µg/$361
TDP-43 / TARDBP Antibody - TARDBP antibody ARP38941_T100-NP_031401-TARDBP (TAR DNA binding protein) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TDP-43 / TARDBP Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$397
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TDP-43 / TARDBP Mouse anti-Human Monoclonal (7F9A6) Antibody
Human
ELISA, Flo
Unconjugated
100 µl/$459
Select
TDP-43 / TARDBP Rabbit anti-Human Polyclonal (aa1-30) Antibody
Mouse, Human
IF, IHC, WB
Unconjugated
200 µl/$734
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TDP-43 / TARDBP Rabbit anti-Human Polyclonal (aa1-30) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
TDP-43 / TARDBP Antibody - Anti-TARDBP antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Select
TDP-43 / TARDBP Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$485
TDP-43 / TARDBP Antibody - Western blot analysis of extracts of various cell lines, using TARDBP antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 1s.
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TDP-43 / TARDBP Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
TDP-43 / TARDBP Antibody - Western blot of recombinant TDP-43 / TARDBP.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TDP-43 / TARDBP Rabbit anti-Mouse Polyclonal (aa104-262) Antibody
Mouse
WB
Unconjugated
100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206
TDP-43 / TARDBP Antibody - Immunohistochemistry of paraffin-embedded human liver cancer tissue.
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TDP-43 / TARDBP Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, IP, RnaIP, WB
Unconjugated
20 µl/$275; 100 µl/$389
Select
TDP-43 / TARDBP Rabbit anti-Human Polyclonal Antibody
Human
ELISA, Flo, IF, IHC, IP, WB
Unconjugated
100 µg/$341
Select
TDP-43 / TARDBP Rabbit anti-Human Polyclonal Antibody
Human
ELISA, Flo, IF, IHC, IP, WB
Unconjugated
100 µg/$331
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).