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Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor By similarity. Promotes assembly of stress granules (SGs), when overexpressed.
Gene Name: | cold inducible RNA binding protein |
Synonyms: | CIRBP, A18 hnRNP, A18HNRNP, CIRP |
Target Sequences: | NM_001280 NP_001271.1 Q14011 |
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