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CASP3 / Caspase 3
caspase 3, apoptosis-related cysteine peptidase
CASP3 / Caspase 3 is a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.
| Gene Name: | caspase 3, apoptosis-related cysteine peptidase |
| Family/Subfamily: | Protease , Cysteine C14 |
| Synonyms: | CASP3, Apopain, CASP-3, Caspase-3, CPP32B, CPP32, Cysteine protease CPP32, SCA-1, SREBP cleavage activity 1, Yama, Procaspase3, Caspase 3, CPP-32, PARP cleavage protease, Protein Yama |
| Target Sequences: | NM_004346 NP_004337.2 P42574 |
Publications (16)
1
Caspase-9 and APAF-1 form an active holoenzyme. Rodriguez J, Lazebnik Y. Genes & development. 1999 13:3179-84.
[PubMed:10617566]
[PMC:PMC317200]
2
Tumor cell-selective regulation of NOXA by c-MYC in response to proteasome inhibition. Nikiforov MA, Riblett M, Tang WH, Gratchouck V, Zhuang D, Fernandez Y, Verhaegen M, Varambally S, Chinnaiyan AM, Jakubowiak AJ, Soengas MS. Proceedings of the National Academy of Sciences of the United States of America. 2007 104:19488-93.
[PubMed:18042711]
[PMC:PMC2148316]
3
Apoptosis in the small intestine of neonatal rat using blue light-emitting diode devices and conventional halogen-quartz devices in phototherapy. Tanaka K, Hashimoto H, Tachibana T, Ishikawa H, Ohki T. Pediatric surgery international. 2008 24:837-42. (IHC)
[PubMed:18470518]
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(299)
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(1)
Publications
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(294)
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(5)
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(14)
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(4)
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Low endotoxin level
(1)
CASP3 / Caspase 3 Mouse anti-Human Monoclonal (31A1067 ) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µg/$460
CASP3 / Caspase 3 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
Flo, ICC, IF, IHC, IHC-Fr, WB
Unconjugated
100 µl/$717
CASP3 / Caspase 3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Gerbil, Human
IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
50 µl/$386
CASP3 / Caspase 3 Mouse anti-Human Monoclonal (5E1) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µg/$460
Neuroscience
CASP3 / Caspase 3 Rabbit anti-Human Polyclonal Antibody
Chicken, Bovine, Rabbit, Mouse, Dog, Guinea pig, Rat, Hamster, Human, Monkey, Yeast
IHC, IHC-P, WB
Unconjugated
50 µg/$485
CASP3 / Caspase 3 Rabbit anti-Human Polyclonal (aa126-175) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates
1 Plate/$715
Sandwich
96-Well Strip Plate
Human
0.31 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$585
Sandwich
96-Well Strip Plate
Rat
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$585
CASP3 / Caspase 3 Mouse anti-Human Monoclonal (CPP32 4-1-18) Antibody
Rat, Human
IHC, IHC-P, WB
Unconjugated
0.2 ml/$460
CASP3 / Caspase 3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µg/$1,079
CASP3 / Caspase 3 Rabbit anti-Human Polyclonal (aa149-179) (APC) Antibody
Human
ELISA, Flo, IHC, WB
APC Conjugated
200 µl/$952
CASP3 / Caspase 3 Rabbit anti-Human Polyclonal (aa149-179) (PE) Antibody
Human
ELISA, Flo, IHC, WB
PE Conjugated
200 µl/$952
CASP3 / Caspase 3 Rabbit anti-Human Polyclonal Antibody
Rabbit, Mouse, Dog, Sheep, Bovine, Rat, Hamster, Pig, Human, Monkey
IHC, IHC-P
Unconjugated
0.1 ml/$288; 0.5 ml/$518; 1 ml/$788
CASP3 / Caspase 3 Rabbit anti-Human Polyclonal (N-Terminus) (AF488) Antibody
Human
ELISA, Flo, ICC, IF
AF488 Conjugated
100 µl/$778
CASP3 / Caspase 3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, IP, WB
Unconjugated
20 µl/$287; 100 µl/$431
CASP3 / Caspase 3 Rabbit anti-Human Monoclonal Antibody
Human
IF, IHC, WB
Unconjugated
20 µl/$299; 100 µl/$431
CASP3 / Caspase 3 Mouse anti-Human Monoclonal (5A2) Antibody
Mouse, Rat, Human
IF, IHC-P, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
CASP3 / Caspase 3 Mouse anti-Human Monoclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$321
CASP3 / Caspase 3 Rabbit anti-Human Polyclonal (Internal) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Human, Monkey
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$299
CASP3 / Caspase 3 Rabbit anti-Human Polyclonal (aa207-220) Antibody
Mouse, Pig, Horse, Bat, Human, Monkey
WB
Unconjugated
10 µg/$318; 100 µg/$470
CASP3 / Caspase 3 Rabbit anti-Human Polyclonal (100-180 aa, Internal) Antibody
Mouse, Rat, Human
WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CASP3 / Caspase 3 Rabbit anti-Human Monoclonal (N-Terminus) Antibody
Human
Flo, IF, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
100 µl/$709
CASP3 / Caspase 3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$287; 100 µl/$431
Sandwich
96-Well Strip Plate
Mouse
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates
1 Plate/$782
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