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TGFB1 / TGF Beta 1
transforming growth factor, beta 1
TGFB1 / TGF Beta 1 is a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. Many cells have TGFB receptors, and the protein positively and negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.
| Gene Name: | transforming growth factor, beta 1 |
| Family/Subfamily: | TGF beta , not assigned-TGF beta |
| Synonyms: | TGFB1, CED, DPD1, Diaphyseal dysplasia 1, LAP, Latency-associated peptide, TGF Beta, TGFbeta, TGF-beta 1 protein, TGF-beta-1, TGFB |
| Target Sequences: | NM_000660 NP_000651.3 P01137 |
Publications (13)
1
Blockade of KCa3.1 ameliorates renal fibrosis through the TGF-ß1/Smad pathway in diabetic mice. Huang C, Shen S, Ma Q, Chen J, Gill A, Pollock CA, Chen XM. Diabetes. 2013 62:2923-34. (WB; Zebrafish)
[Full Text Article]
[PubMed:23656889]
[PMC:PMC3717839]
2
Bone regeneration in minipigs by intrafibrillarly-mineralized collagen loaded with autologous periodontal ligament stem cells. Zhang C, Yan B, Cui Z, Cui S, Zhang T, Wang X, Liu D, Yang R, Jiang N, Zhou Y, Liu Y. Scientific reports. 2017 September;7:10519. (Pig)
[Full Text Article]
[PubMed:28874877]
[PMC:PMC5585269]
Related Antibodies: LS-C10852.
3
Integrin a?ß5 in vitro inhibition limits pro-fibrotic response in cardiac fibroblasts of spontaneously hypertensive rats. Perrucci GL, Barbagallo VA, Corlianò M, Tosi D, Santoro R, Nigro P, Poggio P, Bulfamante G, Lombardi F, Pompilio G. Journal of translational medicine. 2018 December;16:352. [Full Text Article]
[PubMed:30541573]
[PMC:PMC6292173]
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TGFB1 / TGF Beta 1
(330)
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(119)
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(69)
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(323)
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TGFB1 / TGF Beta 1 Rabbit anti-Human Polyclonal (310-390 aa, C-terminal) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$460
TGFB1 / TGF Beta 1 Rabbit anti-Human Polyclonal (aa22-50) Antibody
Mouse, Human
IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
TGFB1 / TGF Beta 1 Mouse anti-Human Monoclonal Antibody
Human
ELISA, IHC, IHC-P, Neut, WB
Unconjugated
50 µg/$460
Cancer
TGFB1 / TGF Beta 1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$515
TGFB1 / TGF Beta 1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
100 µl/$332
TGFB1 / TGF Beta 1 Rabbit anti-Mouse Polyclonal (aa151-200) Antibody
Mouse
WB
Unconjugated
100 µl/$397
TGFB1 / TGF Beta 1 Mouse anti-Human Monoclonal (PE) Antibody
Human
Flo
PE Conjugated
100 Tests/$872
TGFB1 / TGF Beta 1 Rabbit anti-Human Polyclonal (aa279-390) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$281; 200 µl/$312; 500 µl/$413; 1 ml/$464; 2 ml/$565; 5 ml/$969
TGFB1 / TGF Beta 1 Mouse anti-Human Monoclonal Antibody
Mouse, Human, Monkey
WB
Unconjugated
500 µg/$326
TGFB1 / TGF Beta 1 Mouse anti-Human Monoclonal (4F9C10) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
100 µl/$355
Sandwich
96-Well Strip Plate
Bovine
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Platelet-Poor Plasma, Serum, Tissue Homogenates
1 Plate/$779
Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Platelet-Poor Plasma, Serum, Tissue Homogenates
1 Plate/$598
Sandwich
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Platelet-Poor Plasma, Serum, Tissue Homogenates
1 Plate/$598
Sandwich
96-Well Strip Plate
Rabbit
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Platelet-Poor Plasma, Serum, Tissue Homogenates
1 Plate/$715
Sandwich
96-Well Microplate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Urine
1 Plate/$559
Sandwich
12 x 8-Well Microstrips
Human
157 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum
1 Plate/$534
Sandwich
96-Well Strip Plate
Mouse
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Sandwich
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$582
Sandwich
96-Well Strip Plate
Rat
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates, Urine
1 Plate/$582
Sandwich
96-Well Strip Plate
Monkey
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CHO Cells
Human IgG4 Fc
Less than 0.06 EU/µg protein (determined by LAL method).
67 kDa
100 µg/$519
E. coli
His, N-Terminal
14.3 kDa
10 µg/$290; 50 µg/$500; 100 µg/$797; 200 µg/$997; 1 mg/$2,139; 500 µg/$1,662; 5 mg/$3,487; 2 mg/$2,329
Human Cells
None
Less than 1.0 EU/µg protein (determined by LAL method).
12.8kD
10 µg/$321; 50 µg/$534; 500 µg/$1,869; 1 mg/$2,991
TGFB1 / TGF Beta 1 Rabbit anti-Pig Polyclonal Antibody
Mouse, Rat, Pig, Human
IHC, WB
Unconjugated
250 µg/$503
TGFB1 / TGF Beta 1 Goat anti-Human Polyclonal Antibody
Human
ELISA, Neut
Unconjugated
100 µg/$444; 1 mg/$1,017
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