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SELPLG / PSGL-1 / CD162
selectin P ligand
SELPLG / PSGL-1 / CD162 is a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.
| Gene Name: | selectin P ligand |
| Synonyms: | SELPLG, CD162 antigen, CLA, CD162, PSGL1, PSGL-1, Selectin P ligand |
| Target Sequences: | NM_003006 NP_002997.2 Q14242 |
Publications (1)
1
Analysis of 142 Northern Chinese patients with peripheral T/NK-Cell lymphomas: subtype distribution, clinicopathologic features, and prognosis. Ren YL, Nong L, Zhang S, Zhao J, Zhang XM, Li T. American journal of clinical pathology. 2012 138:435-47.
[PubMed:22912362]
Related Antibodies: LS-B3879.
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SELPLG / PSGL-1 / CD162
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SELPLG / PSGL-1 / CD162 Rat anti-Human Monoclonal (HECA-452) Antibody
Mouse, Human
Flo, IHC, IHC-P
Unconjugated
50 µg/$460
SELPLG / PSGL-1 / CD162 Mouse anti-Human Monoclonal (TC2) Antibody
Human
Flo, IHC, IHC-P
Unconjugated
0.05 mg/$460
SELPLG / PSGL-1 / CD162 Mouse anti-Human Monoclonal (FITC) (TC2) Antibody
Human
Flo
FITC Conjugated
100 Tests/$337
Sandwich
96-Well Strip Plate
Human
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$764
SELPLG / PSGL-1 / CD162 Rat anti-Mouse Monoclonal (Azide-free, Low Endotoxin) (4RA10) Antibody
Mouse
Flo
Unconjugated, Azide-free, Low Endotoxin
50 µg/$258; 500 µg/$408; 1 mg/$508
SELPLG / PSGL-1 / CD162 Rabbit anti-Mouse Polyclonal (aa94-345) Antibody
Mouse
WB
Unconjugated
100 µl/$301; 200 µl/$340; 500 µl/$470; 1 ml/$535; 2 ml/$698; 5 ml/$1,161
SELPLG / PSGL-1 / CD162 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
SELPLG / PSGL-1 / CD162 Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Human, Chimpanzee, Orangutan, Gibbon
WB
Biotin Conjugated
100 µl/$469
SELPLG / PSGL-1 / CD162 Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA, IHC, IHC-P
Unconjugated
100 µl/$412
SELPLG / PSGL-1 / CD162 Rat anti-Mouse Monoclonal (PE, Cy7) (4RA10) Antibody
Mouse
Flo
PE, Cy7 Conjugated
25 µg/$251; 100 µg/$321
SELPLG / PSGL-1 / CD162 Rabbit anti-Mouse Monoclonal (APC) (001) Antibody
Mouse
Flo
APC Conjugated
25 Tests/$233; 100 Tests/$263
SELPLG / PSGL-1 / CD162 Rabbit anti-Human Polyclonal Antibody
Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
SELPLG / PSGL-1 / CD162 Rabbit anti-Mouse Monoclonal (Preservative Free) (001) Antibody
Mouse
Flo
Unconjugated, Preservative Free
100 µl/$412
SELPLG / PSGL-1 / CD162 Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA
Unconjugated
100 µl/$412
SELPLG / PSGL-1 / CD162 Rabbit anti-Mouse Monoclonal (FITC) (001) Antibody
Mouse
Flo
FITC Conjugated
25 Tests/$233; 100 Tests/$263
SELPLG / PSGL-1 / CD162 Rabbit anti-Mouse Monoclonal (PE) (001) Antibody
Mouse
Flo
PE Conjugated
25 Tests/$233; 100 Tests/$263
SELPLG / PSGL-1 / CD162 Rabbit anti-Human Monoclonal (APC) (031) Antibody
Human
Flo
APC Conjugated
25 Tests/$293; 100 Tests/$376
SELPLG / PSGL-1 / CD162 Mouse anti-Human Monoclonal Antibody
Human
ELISA, Flo, IHC, IHC-P
Unconjugated
100 µl/$412
SELPLG / PSGL-1 / CD162 Mouse anti-Human Monoclonal (KPL-1) Antibody
Human, Baboon, African green monkey, Cynomolgus monkey, Rhesus monkey
Flo, IHC, IHC-P, IP, WB
Unconjugated
100 µg/$288
SELPLG / PSGL-1 / CD162 Rat anti-Mouse Monoclonal (4RA10) Antibody
Mouse
Block, Flo, IP, WB
Unconjugated
25 µg/$236; 100 µg/$251
HEK 293 Cells
Human IgG1 Fc, C-terminus
SDS-PAGE
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant human PSGL-1/Fc is a disulfide-linked homodimer after removal of the signal peptide and the prppeptide. The reduced monomer consists of 526 amino acids and has a predicted molecular mass of 57.1 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh PSGL-1/Fc monomer is approximately 110-120 kDa due to glycosylation.
100 µg/$441
SELPLG / PSGL-1 / CD162 Rabbit anti-Human Polyclonal (Preservative Free) Antibody
Human
ELISA, IHC-P, IP, WB
Unconjugated, Preservative Free
100 µl/$412
SELPLG / PSGL-1 / CD162 Rabbit anti-Human Polyclonal Antibody
Human
IF, IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
SELPLG / PSGL-1 / CD162 Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF, WB
Unconjugated
30 µl/$266; 50 µl/$286; 100 µl/$321; 200 µl/$386
SELPLG / PSGL-1 / CD162 Mouse anti-Human Monoclonal (PSGL1/1601) Antibody
Human
Flo, IF, IHC-P
Unconjugated
20 µg/$371; 100 µg/$574
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product results
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