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CRYAB / Alpha B Crystallin
crystallin, alpha B
Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy. Alternative splicing results in multiple transcript variants.
| Gene Name: | crystallin, alpha B |
| Synonyms: | CRYAB, Alpha-crystallin B chain, CRYA2, Crystallin, alpha B, CTPP2, Heat shock protein beta-5, HSPB5, Alpha B Crystallin, Alpha(B)-crystallin, Rosenthal fiber component, Heat-shock 20 kD like-protein |
| Target Sequences: | NM_001885 NP_001876.1 P02511 |
Publications (5)
1
The anaphase-promoting complex coordinates initiation of lens differentiation. Wu G, Glickstein S, Liu W, Fujita T, Li W, Yang Q, Duvoisin R, Wan Y. Molecular biology of the cell. 2007 18:1018-29.
[PubMed:17215516]
[PMC:PMC1805114]
2
Erratum to: Reaction of small heat-shock proteins to different kinds of cellular stress in cultured rat hippocampal neurons. Bartelt-Kirbach B, Golenhofen N. Cell stress & chaperones. 2014 19:155-8. (ICC; Human)
[Full Text Article]
[PubMed:24198164]
[PMC:PMC3857433]
3
Reaction of small heat-shock proteins to different kinds of cellular stress in cultured rat hippocampal neurons. Bartelt-Kirbach B, Golenhofen N. Cell stress & chaperones. 2014 19:145-53. (ICC; Human)
[Full Text Article]
[PubMed:23959629]
[PMC:PMC3857434]
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CRYAB / Alpha B Crystallin Rabbit anti-Human Polyclonal Antibody
Mouse, Bovine, Rat, Pig, Human
IHC, IHC-P, WB
Unconjugated
50 µg/$495
CRYAB / Alpha B Crystallin Mouse anti-Human Monoclonal (6D11) Antibody
Mouse, Rat, Human, Monkey
Flo, IF, IHC, IHC-P, IP, WB
Unconjugated
50 µl/$460
CRYAB / Alpha B Crystallin Rabbit anti-Human Polyclonal Antibody
Chicken, Bovine, Mouse, Rat, Human
ICC, IHC, IHC-P, WB
Unconjugated
50 µl/$460
CRYAB / Alpha B Crystallin Mouse anti-Bovine Monoclonal (1B6.1-3G4) Antibody
Chicken, Bovine, Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µg/$535
CRYAB / Alpha B Crystallin Mouse anti-Human Monoclonal (1A7.D5) Antibody
Bovine, Human
ELISA, IHC, IHC-P, WB
Unconjugated
100 µg/$460
CRYAB / Alpha B Crystallin Rabbit anti-Human Polyclonal (pSer59) Antibody
Mouse, Dog, Sheep, Bovine, Rat, Pig, Human
IP, WB
Unconjugated
50 µg/$668; 200 µg/$1,098
Sandwich
96-Well Microplate
Human
0.16 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
CRYAB / Alpha B Crystallin Mouse anti-Human Monoclonal (1D11C6E6) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$460
CRYAB / Alpha B Crystallin Mouse anti-Human Monoclonal (4A6) Antibody
Human
Flo, IF, IHC, IHC-P, IP, WB
Unconjugated
100 µl/$485
CRYAB / Alpha B Crystallin Mouse anti-Human Monoclonal (OTI2A1) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
CRYAB / Alpha B Crystallin Mouse anti-Human Monoclonal (Carrier-free) (OTI2A1) Antibody
Human
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
CRYAB / Alpha B Crystallin Rabbit anti-Human Polyclonal (aa31-80) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$748
Sandwich CLIA
12 x 8-Well Microstrips
Human
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
E. coli
His-SUMO
36.1 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
CRYAB / Alpha B Crystallin Mouse anti-Human Monoclonal (3A10.H4) Antibody
Bovine, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
CRYAB / Alpha B Crystallin Rabbit anti-Human Polyclonal (pSer59) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µl/$334; 100 µl/$397
CRYAB / Alpha B Crystallin Mouse anti-Human Monoclonal (aa1-175) (2E8) Antibody
Human
ELISA, WB
Unconjugated
0.1 mg/$544
CRYAB / Alpha B Crystallin Mouse anti-Human Monoclonal (2E8) Antibody
Human
ELISA, WB
Unconjugated
50 µl/$303; 100 µl/$365
CRYAB / Alpha B Crystallin Mouse anti-Human Monoclonal (Carrier-free) (6D11) Antibody
Rat, Human, Monkey
Flo, IF, IHC, IP, WB
Unconjugated, Carrier-free
100 µg/$511
CRYAB / Alpha B Crystallin Mouse anti-Human Monoclonal (Carrier-free) (4A6) Antibody
Human
Flo, IF, IHC, IP, WB
Unconjugated, Carrier-free
100 µg/$511
CRYAB / Alpha B Crystallin Mouse anti-Human Monoclonal (OTI6A9) Antibody
Rat, Human
Flo, IF, IHC, IHC-P, IP, WB
Unconjugated
100 µl/$434
CRYAB / Alpha B Crystallin Mouse anti-Human Monoclonal (Carrier-free) (OTI6A9) Antibody
Rat, Human
Flo, IF, IHC, IP, WB
Unconjugated, Carrier-free
100 µg/$511
CRYAB / Alpha B Crystallin Mouse anti-Human Monoclonal (Carrier-free) (OTI6G5) Antibody
Human
Flo, IHC, IP, WB
Unconjugated, Carrier-free
100 µg/$511
CRYAB / Alpha B Crystallin Mouse anti-Human Monoclonal (Carrier-free) (OTI3C2) Antibody
Human
Flo, IHC, IP, WB
Unconjugated, Carrier-free
100 µg/$511
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