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Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself.
Gene Name: | euchromatic histone-lysine N-methyltransferase 2 |
Synonyms: | EHMT2, BAT8, C6orf30, Em:AF134726.3, KMT1C, G9A, GAT8, H3-K9-HMTase 3, Protein G9a, G9A histone methyltransferase, HLA-B associated transcript 8, HLA-B-associated transcript 8, Lysine N-methyltransferase 1C, NG36 |
Target Sequences: | NM_006709 NP_006700.3 Q96KQ7 |
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