OPTN / Optineurin

optineurin

Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as of transferrin receptor (TFRC/TfR); regulates Rab8 recruitnment to tubules emanating from the endocytic recycling compartment. Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy), such as cytoplasmic Salmonella enterica, and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52. May constitute a cellular target for adenovirus E3 14.7, an inhibitor of TNF-alpha functions, thereby affecting cell death.

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Antibodies (50)

Proteins (20)

ELISA Kits (1)

Type

Over-Expression Lysate (12)

Primary (50)

Recombinant (8)

Sandwich (1)

Target

OPTN / Optineurin (71)

Reactivity

Human (50)

Mouse (21)

Rat (8)

Bat (4)

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Chimpanzee (9)

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Gibbon (9)

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IHC-P (4)

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Host

rabbit (47)

mouse (3)

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IHCPlus (3)

Isotype

IgG (21)

IgG1 (2)

Clonality

monoclonal mc (3)

polyclonal pc (47)

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aa2-200 (8)

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aa72-121 (4)

aa1-50 (1)

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aa241-577 (1)

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Publications

No (70)

Yes (1)

Sample Type

Tissue Homogenates (1)

Tag

6His, N-terminus (2)

9His, C-terminus (1)

GST (2)

His (1)

His-T7 (1)

Myc-DDK (Flag) (13)

Species

Human (13)

Mouse (1)

Source

293T Cells (6)

Baculovirus (1)

E. coli (3)

HEK 293 Cells (7)

Wheat Germ Extract (2)

Yeast (1)

Purification

Purified (5)

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IHC-plus™ OPTN / Optineurin Antibody (aa115-130) LS-B2096

(4.0) Rating

Antibody:

OPTN / Optineurin Rabbit anti-Human Polyclonal (aa115-130) Antibody

Reactivity:

Human, Monkey

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

125 µl/$460

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IHC-plus™ OPTN / Optineurin Antibody (aa559-575) LS-B3065

(4.0) Rating

Antibody:

OPTN / Optineurin Rabbit anti-Human Polyclonal (aa559-575) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

125 µl/$575

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IHC-plus™ OPTN / Optineurin Antibody (aa575-591) LS-B1611

(4.0) Rating

Antibody:

OPTN / Optineurin Rabbit anti-Human Polyclonal (aa575-591) Antibody

Reactivity:

Rabbit, Mouse, Dog, Rat, Horse, Bat, Human, Monkey

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

1 Each/$485

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OPTN / Optineurin Antibody LS-C331724

(4.0) Rating

(1) Publication(s)

Antibody:

OPTN / Optineurin Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

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OPTN / Optineurin Antibody (C-Terminus) LS-C80594

Antibody:

OPTN / Optineurin Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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OPTN / Optineurin Antibody LS-C754787

Antibody:

OPTN / Optineurin Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$371

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OPTN / Optineurin Antibody LS-C754786

Antibody:

OPTN / Optineurin Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IP, WB

Format:

Unconjugated

Price:

100 µg/$331

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OPTN / Optineurin Antibody LS-C806263

Antibody:

OPTN / Optineurin Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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Human OPTN / Optineurin Protein (Recombinant 6His, N-terminus) (aa1-577) - LS-G57236

Source:

Yeast

Tag:

6His, N-terminus

Price:

100 µg/$570; 20 µg/$395; 1 mg/$1,973

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OPTN / Optineurin Antibody (aa241-577) LS-C357528

Antibody:

OPTN / Optineurin Rabbit anti-Human Polyclonal (aa241-577) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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OPTN / Optineurin Antibody (clone OTI7H2) LS-C796267

Antibody:

OPTN / Optineurin Mouse anti-Human Monoclonal (OTI7H2) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µl/$434

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OPTN / Optineurin Antibody LS-C341358

Antibody:

OPTN / Optineurin Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

50 µl/$356; 100 µl/$461

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OPTN / Optineurin Antibody LS-C488558

Antibody:

OPTN / Optineurin Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IP, WB

Format:

Unconjugated

Price:

100 µl/$412

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OPTN / Optineurin Antibody (aa71-96) LS-C323533

Antibody:

OPTN / Optineurin Rabbit anti-Human Polyclonal (aa71-96) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

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OPTN / Optineurin Antibody (aa71-96, Biotin) LS-C223545

Antibody:

OPTN / Optineurin Rabbit anti-Human Polyclonal (aa71-96) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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OPTN / Optineurin Antibody (aa71-96, FITC) LS-C226931

Antibody:

OPTN / Optineurin Rabbit anti-Human Polyclonal (aa71-96) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

200 µl/$952

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OPTN / Optineurin Antibody (aa71-96, APC) LS-C223544

Antibody:

OPTN / Optineurin Rabbit anti-Human Polyclonal (aa71-96) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

200 µl/$952

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OPTN / Optineurin Antibody (aa71-96, Azide-free, HRP) LS-C226929

Antibody:

OPTN / Optineurin Rabbit anti-Human Polyclonal (aa71-96) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

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OPTN / Optineurin Antibody (aa71-96, PE) LS-C226930

Antibody:

OPTN / Optineurin Rabbit anti-Human Polyclonal (aa71-96) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• HRP, Azide-free
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • HRP, Azide-free
  • PE

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OPTN / Optineurin Antibody (aa504-554) LS-C288607

Antibody:

OPTN / Optineurin Rabbit anti-Human Polyclonal (aa504-554) Antibody

Reactivity:

Human

Applications:

IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

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OPTN / Optineurin Antibody LS-C488560

Antibody:

OPTN / Optineurin Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Unconjugated

Price:

100 µl/$412

Select

OPTN / Optineurin Antibody (aa1-300) LS-C373004

Antibody:

OPTN / Optineurin Rabbit anti-Mouse Polyclonal (aa1-300) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261

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OPTN / Optineurin Antibody (aa1-300, FITC) LS-C694203

Antibody:

OPTN / Optineurin Rabbit anti-Mouse Polyclonal (aa1-300) (FITC) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$352; 200 µl/$412; 500 µl/$622; 1 ml/$777; 2 ml/$1,014; 5 ml/$1,765

• Unconjugated
• FITC

• Unconjugated
• FITC

Select

OPTN / Optineurin Antibody LS-C482314

Antibody:

OPTN / Optineurin Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

50 µl/$286; 100 µl/$321; 200 µl/$386

Select

OPTN / Optineurin Antibody (aa71-96) LS-C158444

Antibody:

OPTN / Optineurin Rabbit anti-Human Polyclonal (aa71-96) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

400 µl/$393

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