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SREBF1 / SREBP-1

sterol regulatory element binding transcription factor 1

SREBF1 / SREBP-1 is a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene.

Gene Name:	sterol regulatory element binding transcription factor 1
Synonyms:	SREBF1, BHLHd1, SREBP-1, SREBP-1c, SREBP1
Target Sequences:	NM_004176 NP_004167.3 P36956

Publications (14)

Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver. Sheng Z, Otani H, Brown MS, Goldstein JL. Proceedings of the National Academy of Sciences of the United States of America. 1995 92:935-8. [PubMed:7862668] [PMC:PMC42611]

Assignment of the membrane attachment, DNA binding, and transcriptional activation domains of sterol regulatory element-binding protein-1 (SREBP-1). Sato R, Yang J, Wang X, Evans MJ, Ho YK, Goldstein JL, Brown MS. The Journal of biological chemistry. 1994 269:17267-73. [PubMed:8006035]

Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene. Shimano H, Shimomura I, Hammer RE, Herz J, Goldstein JL, Brown MS, Horton JD. The Journal of clinical investigation. 1997 100:2115-24. [PubMed:9329978] [PMC:PMC508404]

Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins. Yabe D, Brown MS, Goldstein JL. Proceedings of the National Academy of Sciences of the United States of America. 2002 99:12753-8. [PubMed:12242332] [PMC:PMC130532]

Dietary cholesterol opposes PUFA-mediated repression of the stearoyl-CoA desaturase-1 gene by SREBP-1 independent mechanism. Kim HJ, Miyazaki M, Ntambi JM. Journal of lipid research. 2002 43:1750-7. [PubMed:12364560]

Regulation of SREBP-1 expression and transcriptional action on HKII and FAS genes during fasting and refeeding in rat tissues. Gosmain Y, Dif N, Berbe V, Loizon E, Rieusset J, Vidal H, Lefai E. Journal of lipid research. 2005 46:697-705. [PubMed:15627654]

Activated sterol regulatory element-binding protein-2 suppresses hepatocyte nuclear factor-4-mediated Cyp3a11 expression in mouse liver. Inoue S, Yoshinari K, Sugawara M, Yamazoe Y. Molecular pharmacology. 2011 79:148-56. [PubMed:20926756]

Species-specific dibutyl phthalate fetal testis endocrine disruption correlates with inhibition of SREBP2-dependent gene expression pathways. Johnson KJ, McDowell EN, Viereck MP, Xia JQ. Toxicological sciences : an official journal of the Society of Toxicology. 2011 120:460-74. (WB; Rat) [PubMed:21266533] [PMC:PMC3061485]

A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism. Herman MA, Peroni OD, Villoria J, Schn MR, Abumrad NA, Blher M, Klein S, Kahn BB. Nature. 2012 484:333-8. (WB; Mouse) [PubMed:22466288] [PMC:PMC3341994]

Hypomorphic sialidase expression decreases serum cholesterol by downregulation of VLDL production in mice. Yang A, Gyulay G, Mitchell M, White E, Trigatti BL, Igdoura SA. Journal of lipid research. 2012 53:2573-85. [PubMed:22984145] [PMC:PMC3494259]

The Niemann-Pick C1 gene is downregulated in livers of C57BL/6J mice by dietary fatty acids, but not dietary cholesterol, through feedback inhibition of the SREBP pathway. Jelinek D, Castillo JJ, Richardson LM, Luo L, Heidenreich RA, Garver WS. The Journal of nutrition. 2012 142:1935-42. (WB; Mouse) [PubMed:22990467] [PMC:PMC3497932]

Hepatic Peroxisome Proliferator-Activated Receptor Gamma Signaling Contributes to Alcohol-Induced Hepatic Steatosis and Inflammation in Mice. Zhang W, Sun Q, Zhong W, Sun X, Zhou Z. Alcoholism, clinical and experimental research. 2016 May;40:988-99. (Human) [Full Text Article] [PubMed:27062444] [PMC:PMC5742869] Related Antibodies: LS-B93.

Heat Shock Factor 1 Is a Direct Antagonist of AMP-Activated Protein Kinase. Kuo-Hui Su, Siyuan Dai, Zijian Tang, Meng Xu, Chengkai Dai. Molecular cell. 2019 November;76:546-561e8. [Full Text Article] [PubMed:31561952] [PMC:PMC8170832]

Protective effects of farnesoid X receptor (FXR) on hepatic lipid accumulation are mediated by hepatic FXR and independent of intestinal FGF15 signal. Schmitt J, Kong B, Stieger B, Tschopp O, Schultze SM, Rau M, Weber A, M[Character fc]llhaupt B, Guo GL, Geier A. Liver international : official journal of the International Association for the Study of the Liver. Apr;35:1133-44. [Full Text Article] [PubMed:25156247] [PMC:PMC4146754] Related Antibodies: LS-C30185.

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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