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SOX4
SRY (sex determining region Y)-box 4
This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein.
| Gene Name: | SRY (sex determining region Y)-box 4 |
| Family/Subfamily: | Transcription factor |
| Synonyms: | SOX4, EVI16, SRY-related HMG-box gene 4, Transcription factor SOX-4 |
| Target Sequences: | NM_003107 NP_003098.1 Q06945 |
Publications (4)
1
SOX4 interacts with plakoglobin in a Wnt3a-dependent manner in prostate cancer cells. Lai YH, Cheng J, Cheng D, Feasel ME, Beste KD, Peng J, Nusrat A, Moreno CS. BMC cell biology. 2011 12:50. (WB; Human)
[Full Text Article]
[PubMed:22098624]
[PMC:PMC3227594]
2
A crucial epithelial to mesenchymal transition regulator, Sox4/Ezh2 axis is closely related to the clinical outcome in pancreatic cancer patients. Hasegawa S, Nagano H, Konno M, Eguchi H, Tomokuni A, Tomimaru Y, Asaoka T, Wada H, Hama N, Kawamoto K, Marubashi S, Nishida N, Koseki J, Mori M, Doki Y, Ishii H. International journal of oncology. 2016 48:145-52. (WB; Human)
[Full Text Article]
[PubMed:26648239]
3
BRAF/EZH2 Signaling Represses miR-129-5p Inhibition of SOX4 Thereby Modulating BRAFi Resistance in Melanoma. Kathleen Gebhardt, Bayram Edemir, Elisabeth Groß, Linda Nemetschke, Stefanie Kewitz-Hempel, Rose K C Moritz, Cord Sunderkötter, Dennis Gerloff. Cancers. 2021 May;13: [Full Text Article]
[PubMed:34063443]
[PMC:PMC8155874]
Related Antibodies: LS-C499849.
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(21)
Yes
(2)
SOX4 Rabbit anti-Human Polyclonal (aa86-114) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
SOX4 Rabbit anti-Human Polyclonal (aa1-60) Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$294; 100 µg/$360
SOX4 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
SOX4 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
SOX4 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA
FITC Conjugated
50 µg/$294; 100 µg/$360
SOX4 Rabbit anti-Human Polyclonal (aa269-297) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
SOX4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
SOX4 Mouse anti-Human Monoclonal (154C4a) Antibody
Human
DB, ICC, IF, WB
Unconjugated
100 µg/$486
SOX4 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, WB
Unconjugated
100 µl/$424
SOX4 Rabbit anti-Human Polyclonal (N-Terminus) (HRP) Antibody
Rabbit, Mouse, Dog, Guinea pig, Bovine, Pig, Gibbon, Human, Monkey, Chimpanzee
IHC, WB
HRP Conjugated
100 µl/$469
SOX4 Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody
Rabbit, Mouse, Dog, Guinea pig, Bovine, Pig, Gibbon, Human, Monkey, Chimpanzee
IHC, WB
Biotin Conjugated
100 µl/$469
SOX4 Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody
Rabbit, Mouse, Dog, Guinea pig, Bovine, Pig, Gibbon, Human, Monkey, Chimpanzee
IHC, WB
FITC Conjugated
100 µl/$469
SOX4 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, WB
Unconjugated
100 µg/$357
SOX4 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
SOX4 Mouse anti-Human Monoclonal (2C5) Antibody
Human
ELISA
Unconjugated
50 µg/$423
SOX4 Rabbit anti-Human Polyclonal (Internal) Antibody
Human
WB
Unconjugated
50 µg/$495
SOX4 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µg/$575
SOX4 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
SOX4 Rabbit anti-Human Polyclonal (N-Terminus) (HRP) Antibody
Human
WB
HRP Conjugated
100 µl/$469
SOX4 Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$469
SOX4 Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody
Human
WB
FITC Conjugated
100 µl/$469
SOX4 Rabbit anti-Human Polyclonal (aa1-31) Antibody
Mouse, Dog, Guinea pig, Sheep, Bovine, Pig, Human
WB
Unconjugated
10 µg/$318; 100 µg/$470
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