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SOX2
SRY (sex determining region Y)-box 2
Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation.
| Gene Name: | SRY (sex determining region Y)-box 2 |
| Family/Subfamily: | Transcription factor |
| Synonyms: | SOX2, MCOPS3, Transcription factor SOX2, ANOP3, Transcription factor SOX-2, SRY-related HMG-box gene 2 |
| Target Sequences: | L07335 AAA35997.1 P48431 |
Publications (8)
1
Developmental changes in the expression of sox2 in the zebrafish brain. Carlisle FA, Steel KP, Lewis MA. Microscopy research and technique. 2010 (WB; Zebrafish)
[PubMed:20734413]
Related Antibodies: LS-C31802.
2
Signaling through BMP receptors promotes respiratory identity in the foregut via repression of Sox2. Domyan ET, Ferretti E, Throckmorton K, Mishina Y, Nicolis SK, Sun X. Development (Cambridge, England). 2011 138:971-81. (ICC, IHC; Mouse)
[PubMed:21303850]
3
Distinct functions of Sox2 control self-renewal and differentiation in the osteoblast lineage. Seo E, Basu-Roy U, Zavadil J, Basilico C, Mansukhani A. Molecular and cellular biology. 2011 31:4593-608.
[PubMed:21930787]
[PMC:PMC3209254]
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(124)
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(124)
Target
SOX2
(124)
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(121)
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(6)
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(6)
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(60)
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(15)
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(27)
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(97)
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(7)
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(1)
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(2)
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(2)
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(1)
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(1)
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(7)
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(4)
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(11)
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(1)
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(1)
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(10)
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(10)
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(7)
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(2)
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(77)
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(8)
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(1)
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(1)
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(1)
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(1)
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(1)
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(1)
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(1)
Publications
No
(121)
Yes
(3)
SOX2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Frog, Mouse, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
SOX2 Rabbit anti-Human Polyclonal (aa29-78) Antibody
Human
WB
Unconjugated
100 µl/$397
SOX2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
SOX2 Rabbit anti-Human Monoclonal (N-Terminus) (SP76) Antibody
Human
IHC, IHC-P, WB
Unconjugated
500 µl/$539
SOX2 Mouse anti-Human Monoclonal (57CT23.3.4) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
SOX2 Rabbit anti-Human Polyclonal (aa100-150) Antibody
Chicken, Pig, Cat, Mouse, Human, Monkey
IHC, IHC-P, WB
Unconjugated
50 µg/$440
SOX2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, ICC, IF, IHC, WB
Unconjugated
0.1 mg/$460
SOX2 Rabbit anti-Human Polyclonal (aa1-100) Antibody
Mouse, Sheep, Human
Flo, IHC, IHC-P
Unconjugated
0.1 ml/$460
SOX2 Mouse anti-Human Monoclonal (SOX2/1791) Antibody
Human
ELISA, IHC-P, WB
Unconjugated
20 µg/$371; 100 µg/$574
SOX2 Mouse anti-Human Monoclonal (10F10) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$435
SOX2 Rabbit anti-Human Polyclonal (aa171-183) Antibody
Rabbit, Mouse, Goat, Guinea pig, Sheep, Bovine, Pig, Horse, Human, Monkey
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
SOX2 Mouse anti-Human Monoclonal (10F10) Antibody
Human
ChIP-Seq, ICC, IF, IHC, WB
Unconjugated
100 µl/$541
SOX2 Rabbit anti-Human Polyclonal (aa89-119) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
SOX2 Mouse anti-Human Monoclonal (57CT23.3.4) Antibody
Human
ELISA, Flo, IF, IHC, WB
Unconjugated
200 µl/$734
SOX2 Mouse anti-Human Monoclonal (Biotin) (57CT23.3.4) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
Biotin Conjugated
200 µl/$952
SOX2 Mouse anti-Human Monoclonal (FITC) (57CT23.3.4) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
FITC Conjugated
200 µl/$952
SOX2 Mouse anti-Human Monoclonal (PE) (57CT23.3.4) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
PE Conjugated
200 µl/$952
SOX2 Mouse anti-Human Monoclonal (APC) (57CT23.3.4) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
APC Conjugated
200 µl/$952
SOX2 Mouse anti-Human Monoclonal (Azide-free) (HRP) (57CT23.3.4) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
SOX2 Rabbit anti-Human Polyclonal (aa227-262) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
SOX2 Mouse anti-Human Monoclonal (3A2) Antibody
Human
ELISA, Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$346
SOX2 Mouse anti-Human Monoclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$332; 100 µg/$404; 200 µg/$505
SOX2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
SOX2 Rabbit anti-Human Monoclonal (OR-4F2) Antibody
Human
WB
Unconjugated
100 µl/$469
SOX2 Rabbit anti-Human Monoclonal (OR-2D11) Antibody
Human
WB
Unconjugated
100 µl/$469
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