SORT1 / Sortilin

sortilin 1

Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi.

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Products

Proteins (6)

Type

Recombinant (6)

Target

SORT1 / Sortilin (6)

Publications

No (6)

Tag

6His, N-terminus (1)

GST, N-terminus (1)

His (1)

His, N-Terminal (1)

His-GST (1)

His-SUMO (1)

Species

Human (2)

Mouse (1)

Rat (3)

Source

293F Cells (1)

E. coli (3)

Wheat Germ Extract (1)

Yeast (1)

Purification

Purified (2)

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Human SORT1 / Sortilin Protein (Recombinant His-GST) (aa50-320) - LS-G25158

Source:

E. coli

Tag:

His-GST

Molecular Weight:

59.7 kDa

Price:

10 µg/$282; 50 µg/$450; 100 µg/$717; 200 µg/$897; 1 mg/$2,010; 500 µg/$1,547; 5 mg/$3,137; 2 mg/$2,198

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Human SORT1 / Sortilin Protein (Recombinant GST, N-terminus) (aa203-299) - LS-G60017

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Mouse SORT1 / Sortilin Protein (Recombinant His, N-Terminal) (Arg74-Ser754) - LS-G132938

Source:

293F Cells

Tag:

His, N-Terminal

Price:

10 µg/$317; 50 µg/$670; 200 µg/$1,253; 100 µg/$1,055; 1 mg/$2,503; 500 µg/$2,003; 5 mg/$4,677; 2 mg/$2,695

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Rat SORT1 / Sortilin Protein (Recombinant His-SUMO) (aa610-754) - LS-G21209

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

32.5 kD

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Rat SORT1 / Sortilin Protein (Recombinant His) (aa610-754) - LS-G23144

Source:

Yeast

Tag:

His

Molecular Weight:

18.5 kD

Price:

100 µg/$499; 20 µg/$364; 1 mg/$1,683

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Rat SORT1 / Sortilin Protein (Recombinant 6His, N-terminus) - LS-G137119

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

20.5 kDa

Price:

100 µg/$500; 20 µg/$364; 1 mg/$1,679

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