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SLC6A4 / SERT

solute carrier family 6 (neurotransmitter transporter), member 4

SLC6A4 / SERT is an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma.

Gene Name: solute carrier family 6 (neurotransmitter transporter), member 4
Family/Subfamily: Transporter , Neurotransmitter:sodium symporter
Synonyms: SLC6A4, 5HTT, 5HT transporter, 5-HTT, 5-HTTLPR, OCD1, SERT, Serotonin transporter, HSERT, SERT1
Target Sequences: NM_001045 NP_001036.1 P31645

Publications (1)

1
Pathway of Maternal Serotonin to the Human Embryo and Fetus. Kliman HJ, Quaratella SB, Setaro AC, Siegman EC, Subha ZT, Tal R, Milano KM, Steck TL. Endocrinology. 2018 April;159:1609-1629. [Full Text Article] [PubMed:29381782] Related Antibodies: LS-C179236.

☰ Filters
Antibodies (49)
ELISA Kits (20)
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SLC6A4 / SERT (75)
Human (47)
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SLC6A4 / SERT Antibody - IHC detection of SLC6A4 on paraffin-embedded Human cerebral cortex.
Select
SLC6A4 / SERT Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$447
SLC6A4 / SERT Antibody - SLC6A4 antibody IHC-paraffin. IHC(P): Rat Brain Tissue.
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SLC6A4 / SERT Rabbit anti-Human Polyclonal (aa57-85) Antibody
Rat, Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
SLC6A4 / SERT Antibody - SLC6A4 / SERT antibody immunofluorescence analysis of paraformaldehyde fixed HepG2 cells, permeabilized with 0.15% Triton. Primary incubation 1hr (10ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml), showing Golgi apparatus/vesicle staining. The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml).
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SLC6A4 / SERT Goat anti-Human Polyclonal (aa605-618) Antibody
Mouse, Guinea pig, Rat, Horse, Human, Monkey
IF, Peptide-ELISA
Unconjugated
100 µg/$503
Select
SLC6A4 / SERT Rabbit anti-Rat Polyclonal (Extracellular Domain) Antibody
Rat, Human
ELISA, WB
Unconjugated
100 µl/$801
Select
SLC6A4 / SERT Rabbit anti-Rat Polyclonal (aa579-599) Antibody
Rat
IHC, WB
Unconjugated
100 µl/$856
SLC6A4 / SERT Antibody - Western blot analysis of lysates from brain tissue , using ST antibody.
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SLC6A4 / SERT Rabbit anti-Human Polyclonal (aa348-397) Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
SLC6A4 / SERT Antibody - Western blot analysis of extracts of various cell lines, using SLC6A4 antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 30s.
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SLC6A4 / SERT Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 100 µl/$389
SLC6A4 / SERT ELISA Kit
Select
Sandwich
96-Well Microplate
Human
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
SLC6A4 / SERT Antibody - SLC6A4 / 5HTT / SERT Antibody Immunofluorescence analysis of paraformaldehyde fixed HepG2 cells, permeabilized with 0.15% Triton. Primary incubation 1hr (10ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml), showing vesicle staining. The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml).
Select
SLC6A4 / SERT Goat anti-Human Polyclonal (aa116-126) Antibody
Human, Monkey
IF, Peptide-ELISA, WB
Unconjugated
100 µg/$503
SLC6A4 / SERT Antibody - 1:100 staining mouse colon tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
Select
SLC6A4 / SERT Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human, Monkey
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
SLC6A4 / SERT Antibody - Immunohistochemistry of paraffin-embedded Human thyroid cancer using SLC6A4 Polyclonal Antibody at dilution of 1:50.
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SLC6A4 / SERT Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
Select
SLC6A4 / SERT Rabbit-New Zealand White anti-Human Polyclonal Antibody
Human
IHC, WB
Unconjugated
100 µl/$393
Select
SLC6A4 / SERT Rabbit-New Zealand White anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
100 µl/$393
Select
SLC6A4 / SERT Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
SLC6A4 / SERT Antibody - SLC6A4 / SERT antibody. IHC(P): Rat Brain Tissue.
Select
SLC6A4 / SERT Rabbit anti-Rat Polyclonal (aa7-24) Antibody
Rat
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
Select
SLC6A4 / SERT Rabbit anti-Rat Polyclonal (Extracellular Domain) Antibody
Rat, Human
ELISA, WB
Unconjugated
100 µg/$832
SLC6A4 / SERT Antibody - Detection limit for recombinant GST tagged SLC6A4 is approximately 0.3 ng/ml as a capture antibody.
Select
SLC6A4 / SERT Mouse anti-Human Monoclonal (2A9) Antibody
Human
ELISA
Unconjugated
100 µg/$423
Select
SLC6A4 / SERT Rabbit anti-Human Polyclonal (aa1-630) Antibody
Mouse, Human
WB
Unconjugated
100 µg/$749
Select
SLC6A4 / SERT Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µg/$832
Select
SLC6A4 / SERT Rabbit anti-Human Polyclonal Antibody
Mouse, Human
WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
SLC6A4 / SERT Antibody - Western blot testing of SERT antibody and Lane 1: U87; 2: HeLa; 3: Jurkat cell lysate. Expected molecular weight: ~70/85-95kDa (unmodified/glycosylated).
Select
SLC6A4 / SERT Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µg/$575
SLC6A4 / SERT Antibody - Western blot analysis of extracts of various cell lines, using SLC6A4 antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 90s.
Select
SLC6A4 / SERT Rabbit anti-Human Polyclonal Antibody
Mouse, Human
WB
Unconjugated
20 µl/$275; 100 µl/$389
SLC6A4 / SERT Antibody - Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
SLC6A4 / SERT Mouse anti-Rat Monoclonal (aa1-85) (2D7/3) Antibody
Mouse, Rat
IHC-Fr, IHC-P
Unconjugated
0.1 mg/$1,110
SLC6A4 / SERT Antibody - WB of SLC6A4 / SERT antibody. Lane 1: U87 Cell Lysate. Lane 2: HELA Cell Lysate. Lane 3: JURKAT Cell Lysate.
Select
SLC6A4 / SERT Rabbit anti-Human Polyclonal (aa7-24) Antibody
Rat, Human
WB
Unconjugated
10 µg/$318; 100 µg/$470
SLC6A4 / SERT Antibody - Western blot of SLC6A4 / SERT antibody.
Select
SLC6A4 / SERT Rabbit anti-Human Polyclonal (aa181-252) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225
Viewing 1-25 of 75 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).