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SIRT6 / Sirtuin 6
sirtuin 6
NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD+ in the absence of acetylated substrate.
| Gene Name: | sirtuin 6 |
| Synonyms: | SIRT6, SIR2-like protein 6, Sirtuin type 6, SIR2L6, Sir2-related protein type 6, Sirtuin 6 |
| Target Sequences: | NM_016539 NP_057623.2 Q8N6T7 |
Publications (8)
1
Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin. Min L, Ji Y, Bakiri L, Qiu Z, Cen J, Chen X, Chen L, Scheuch H, Zheng H, Qin L, Zatloukal K, Hui L, Wagner EF. Nature cell biology. 2012 14:1203-11. (IHC, WB; Mouse, Human)
[PubMed:23041974]
2
The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun. Sundaresan NR, Vasudevan P, Zhong L, Kim G, Samant S, Parekh V, Pillai VB, Ravindra PV, Gupta M, Jeevanandam V, Cunningham JM, Deng CX, Lombard DB, Mostoslavsky R, Gupta MP. Nature medicine. 2012 18:1643-50. (WB; Mouse)
[PubMed:23086477]
3
SIRT3 SIRT7: Potential Novel Biomarkers for Determining Outcome in Pancreatic Cancer Patients. McGlynn LM, McCluney S, Jamieson NB, Thomson J, MacDonald AI, Oien K, Dickson EJ, Carter CR, McKay CJ, Shiels PG. PloS one. 2015 10:e0131344. (WB, ELISA; Human)
[Full Text Article]
[PubMed:26121130]
[PMC:PMC4487247]
Related Antibodies: LS-B900.
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(74)
Yes
(2)
SIRT6 / Sirtuin 6 Rabbit anti-Human Polyclonal (aa56-105) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
SIRT6 / Sirtuin 6 Rabbit anti-Human Polyclonal (aa56-105) (HRP) Antibody
Mouse, Dog, Hamster, Pig, Bat, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
HRP Conjugated
100 µl/$442
SIRT6 / Sirtuin 6 Rabbit anti-Human Polyclonal (aa56-105) (Biotin) Antibody
Mouse, Dog, Hamster, Pig, Bat, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$442
SIRT6 / Sirtuin 6 Rabbit anti-Human Polyclonal (aa305-320) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$460
SIRT6 / Sirtuin 6 Rabbit anti-Human Polyclonal (aa290-319) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
SIRT6 / Sirtuin 6 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
SIRT6 / Sirtuin 6 Rabbit anti-Human Polyclonal (aa14-180) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
SIRT6 / Sirtuin 6 Rabbit anti-Human Polyclonal (Internal) (Biotin) Antibody
Human
WB
Biotin Conjugated
0.1 ml/$416
SIRT6 / Sirtuin 6 Rabbit anti-Human Polyclonal (aa50-100) Antibody
Human
IHC, IHC-P, IP
Unconjugated
50 µl/$460
SIRT6 / Sirtuin 6 Rabbit anti-Human Polyclonal (aa276-305) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
SIRT6 / Sirtuin 6 Rabbit anti-Human Polyclonal (aa276-305) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
SIRT6 / Sirtuin 6 Rabbit anti-Human Polyclonal (aa276-305) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
SIRT6 / Sirtuin 6 Rabbit anti-Human Polyclonal (aa276-305) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
SIRT6 / Sirtuin 6 Rabbit anti-Human Polyclonal (aa276-305) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
SIRT6 / Sirtuin 6 Rabbit anti-Human Polyclonal (aa290-319) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
SIRT6 / Sirtuin 6 Rabbit anti-Human Polyclonal (aa290-319) (FITC) Antibody
Mouse, Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
SIRT6 / Sirtuin 6 Rabbit anti-Human Polyclonal (aa290-319) (APC) Antibody
Mouse, Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
SIRT6 / Sirtuin 6 Rabbit anti-Human Polyclonal (aa290-319) (PE) Antibody
Mouse, Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
SIRT6 / Sirtuin 6 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$341
SIRT6 / Sirtuin 6 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IF, IP, WB
Unconjugated
100 µl/$688
SIRT6 / Sirtuin 6 Rabbit anti-Mouse Polyclonal Antibody
Mouse, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
SIRT6 / Sirtuin 6 Mouse anti-Human Monoclonal (2G1H1) Antibody
Human
ELISA, Flo
Unconjugated
100 µl/$459
SIRT6 / Sirtuin 6 Mouse anti-Human Monoclonal Antibody
Mouse, Rat, Human, Monkey
ELISA, WB
Unconjugated
50 µg/$332; 100 µg/$404; 200 µg/$505
SIRT6 / Sirtuin 6 Mouse anti-Human Monoclonal (OTI1G3) Antibody
Human
IF, WB
Unconjugated
100 µl/$434
SIRT6 / Sirtuin 6 Rabbit anti-Human Polyclonal (aa276-305) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
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