SHH / Sonic Hedgehog

sonic hedgehog

SHH / Sonic Hedgehog is a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. It is also thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities. Additionally, mutations in a long range enhancer located approximately 1 megabase upstream of this gene disrupt limb patterning and can result in preaxial polydactyly.

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Products

Proteins (34)

Type

Over-Expression Lysate (2)

Recombinant (32)

Target

SHH / Sonic Hedgehog (34)

Publications

No (34)

Tag

6His, C-terminus (2)

GST, N-terminus (1)

His (6)

His-T7 (2)

Myc-DDK (Flag) (3)

Species

Human (18)

Mouse (13)

Rat (2)

Source

293T Cells (1)

E. coli (26)

HEK 293 Cells (2)

Human (2)

Human Cells (2)

Wheat Germ Extract (1)

Purification

Purified (10)

Low Endotoxin Level

Low endotoxin level (24)

Biologically Active

Biologically active (11)

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Mouse SHH / Sonic Hedgehog Protein (Recombinant) - LS-G375

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.1 ng/µg of protein (less than 1EU/µg).

Molecular Weight:

20.0 kDa

Price:

5 µg/$268; 25 µg/$349

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Rat SHH / Sonic Hedgehog Protein (Recombinant His) (aa28-192) - LS-G14338

Source:

E. coli

Tag:

His

Molecular Weight:

20.4 kDa

Price:

10 µg/$288; 50 µg/$487; 100 µg/$780; 200 µg/$972; 1 mg/$2,109; 500 µg/$1,636; 5 mg/$3,403; 2 mg/$2,298

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Human SHH / Sonic Hedgehog Protein (Recombinant) - LS-G46

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.1 ng/µg of protein (less than 1EU/µg).

Molecular Weight:

20.0 kDa

Price:

5 µg/$268; 25 µg/$349

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Human SHH / Sonic Hedgehog Protein (Recombinant) - LS-G3251

Source:

E. coli

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Price:

50 µg/$361; 250 µg/$739; 10 µg/$261

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Human SHH / Sonic Hedgehog Protein (Recombinant) (aa25-197) - LS-G5584

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Molecular Weight:

19.8 kDa

Price:

5 µg/$282; 100 µg/$893; 500 µg/$1,668

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Mouse SHH / Sonic Hedgehog Protein (Recombinant) (aa26-198) - LS-G5595

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Molecular Weight:

19.8 kDa

Price:

5 µg/$282; 100 µg/$893; 500 µg/$1,668

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Human SHH / Sonic Hedgehog Protein (Recombinant) (Cys24-Gly197) - LS-G38638

Source:

E. coli

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

19.69kD

Price:

10 µg/$288; 50 µg/$442; 500 µg/$1,353; 1 mg/$1,725

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Human SHH / Sonic Hedgehog Protein (Recombinant) (Cys24-Gly197) - LS-G38628

Source:

E. coli

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

19.8kD

Price:

10 µg/$297; 50 µg/$468; 500 µg/$1,585; 1 mg/$2,157

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Mouse SHH / Sonic Hedgehog Protein (Recombinant) (Cys25-Gly198) - LS-G39841

Source:

E. coli

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

19.8kD

Price:

10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157

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Mouse SHH / Sonic Hedgehog Protein (Recombinant) (Cys25-Gly198) - LS-G39844

Source:

E. coli

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

19.8kD

Price:

10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157

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Human SHH / Sonic Hedgehog Protein (Recombinant GST, N-terminus) (aa181-280) - LS-G60083

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human SHH / Sonic Hedgehog Protein (Recombinant His) (Met1-Gly197) - LS-G97887

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

21 kDa

Price:

20 µg/$383; 100 µg/$713

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Human SHH / Sonic Hedgehog Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68001

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

47.2 kDa

Price:

20 µg/$1,107

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Human SHH / Sonic Hedgehog Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81212

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

50.1 kDa

Price:

20 µg/$215

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Human SHH / Sonic Hedgehog Protein (Recombinant) (Cys24-Gly197) - LS-G139962

Source:

E. coli

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

19.8 kDa

Price:

10 µg/$297; 50 µg/$460

Select

Human SHH / Sonic Hedgehog Protein (Recombinant) - LS-G145693

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 1 EU/µg (determined by LAL method).

Molecular Weight:

19.8 kDa

Price:

1 mg/$2,573; 25 µg/$372

Select

Human SHH / Sonic Hedgehog Protein (Recombinant 6His, C-terminus) - LS-G146075

Source:

Human

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

20.4 kDa

Price:

10 µg/$290; 50 µg/$446

Select

Mouse SHH / Sonic Hedgehog Protein (Recombinant 6His, C-terminus) - LS-G146260

Source:

Human

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

20.4 kDa

Price:

10 µg/$279; 50 µg/$415

Select

SHH / Sonic Hedgehog Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G123337

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

50.1 kDa

Price:

100 µg/$710

Select

Human SHH / Sonic Hedgehog Protein (Recombinant) - LS-G131371

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

~20.1 kDa

Price:

30 µg/$310; 100 µg/$413; 1 mg/$1,539

Select

Mouse SHH / Sonic Hedgehog Protein (Recombinant) - LS-G136830

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

19.8 kDa

Price:

50 µg/$516; 10 µg/$313; 1 mg/$2,837; 500 µg/$1,987

Select

Human SHH / Sonic Hedgehog Protein (Recombinant) (Cys24-Gly197) - LS-G139783

Source:

E. coli

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

19.69 kDa

Price:

10 µg/$288; 50 µg/$436

Select

Mouse SHH / Sonic Hedgehog Protein (Recombinant) (Cys25-Gly198) - LS-G139878

Source:

E. coli

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

19.8 kDa

Price:

10 µg/$288; 50 µg/$436

Select

Mouse SHH / Sonic Hedgehog Protein (Recombinant) (Cys25-Gly198) - LS-G139883

Source:

E. coli

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

19.8 kDa

Price:

10 µg/$288; 50 µg/$436

Select

Mouse SHH / Sonic Hedgehog Protein (Recombinant) - LS-G131560

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Price:

25 µg/$310; 250 µg/$1,090; 1 mg/$1,539

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