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SERPINA1 / Alpha 1 Antitrypsin
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.Short peptide from AAT: reversible chymotrypsin inhibitor. It also inhibits elastase, but not trypsin. Its major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE).
| Gene Name: | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 |
| Synonyms: | SERPINA1, A1A, A1AT, AAT, Alpha 1 Antitrypsin, Alpha-1 protease inhibitor, Alpha-1-antiproteinase, Alpha-1-antitrypsin, Alpha1AT, PRO2275, Alpha-1-antitrypsin null, PI1, Serpin A1, Alpha 1 AT |
| Target Sequences: | K02212 AAB59495.1 P01009 |
Publications (5)
1
Skeletal muscle lipogenic protein expression is not different between lean and obese individuals: a potential factor in ceramide accumulation. Thrush AB, Brindley DN, Chabowski A, Heigenhauser GJ, Dyck DJ. The Journal of clinical endocrinology and metabolism. 2009 94:5053-61.
[PubMed:19837942]
2
Derlin-2-deficient mice reveal an essential role for protein dislocation in chondrocytes. Dougan SK, Hu CC, Paquet ME, Greenblatt MB, Kim J, Lilley BN, Watson N, Ploegh HL. Molecular and cellular biology. 2011 31:1145-59. (WB, IP; Mouse)
[PubMed:21220515]
[PMC:PMC3067910]
3
Dual role of ancient ubiquitous protein 1 (AUP1) in lipid droplet accumulation and endoplasmic reticulum (ER) protein quality control. Klemm EJ, Spooner E, Ploegh HL. The Journal of biological chemistry. 2011 286:37602-14.
[PubMed:21857022]
[PMC:PMC3199505]
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Antibodies
(160)
Type
Primary
(160)
Target
SERPINA1 / Alpha 1 Antitrypsin
(160)
Reactivity
Human
(131)
Mouse
(19)
Rat
(24)
Chimpanzee
(3)
Dog
(8)
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(1)
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(10)
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(1)
Application
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(48)
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(3)
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(25)
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(107)
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(8)
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(1)
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(81)
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(62)
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(33)
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(9)
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monoclonal mc
(50)
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(110)
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(2)
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142
(1)
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(13)
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(104)
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(1)
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(1)
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(1)
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(1)
Publications
No
(160)
SERPINA1 / Alpha 1 Antitrypsin Mouse anti-Human Monoclonal (15H10) Antibody
Dog, Human, Monkey
IHC, IHC-P, IP, WB
Unconjugated
50 µl/$460
SERPINA1 / Alpha 1 Antitrypsin Mouse anti-Human Monoclonal (11G2) Antibody
Dog, Human, Monkey
IHC, IHC-P, IP, WB
Unconjugated
50 µl/$460
SERPINA1 / Alpha 1 Antitrypsin Goat anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P, IP, WB
Unconjugated
50 µl/$460
SERPINA1 / Alpha 1 Antitrypsin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$775
Cancer Pathology
Cancer
SERPINA1 / Alpha 1 Antitrypsin Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC-P, WB
Unconjugated
50 µl/$460
SERPINA1 / Alpha 1 Antitrypsin Mouse anti-Human Monoclonal Antibody
Human
ELISA
Unconjugated
1 mg/$1,054
SERPINA1 / Alpha 1 Antitrypsin Sheep anti-Human Polyclonal (HRP) Antibody
Human
ELISA, IE
HRP Conjugated
100 µg/$582
SERPINA1 / Alpha 1 Antitrypsin Goat anti-Human Polyclonal Antibody
Human
ID
Unconjugated
1 ml/$334
SERPINA1 / Alpha 1 Antitrypsin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
SERPINA1 / Alpha 1 Antitrypsin Mouse anti-Human Monoclonal (9A1) Antibody
Dog, Human, Monkey
Flo, IHC, IHC-P, IP, WB
Unconjugated
50 µl/$440
SERPINA1 / Alpha 1 Antitrypsin Mouse anti-Human Monoclonal (Preservative Free) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated, Preservative Free
50 µg/$343
SERPINA1 / Alpha 1 Antitrypsin Mouse anti-Human Monoclonal (1C2) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$485
SERPINA1 / Alpha 1 Antitrypsin Mouse anti-Human Monoclonal (Carrier-free) (9A1) Antibody
Dog, Human, Monkey
Flo, IHC, IP, WB
Unconjugated, Carrier-free
100 µg/$511
SERPINA1 / Alpha 1 Antitrypsin Goat anti-Human Polyclonal (aa33-45) Antibody
Human, Monkey
Peptide-ELISA, WB
Unconjugated
100 µg/$503
SERPINA1 / Alpha 1 Antitrypsin Rabbit anti-Human Monoclonal (Preservative Free) (142) Antibody
Human
ELISA
Unconjugated, Preservative Free
20 µl/$271; 100 µl/$412
SERPINA1 / Alpha 1 Antitrypsin Rabbit anti-Mouse Polyclonal (aa25-413) Antibody
Mouse
WB
Unconjugated
100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206
SERPINA1 / Alpha 1 Antitrypsin Mouse anti-Human Monoclonal (5B12) Antibody
Dog, Human, Monkey
IHC, IHC-P, IP, WB
Unconjugated
50 µl/$460
SERPINA1 / Alpha 1 Antitrypsin Rabbit anti-Rat Polyclonal (aa211-411) Antibody
Mouse, Rat
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
SERPINA1 / Alpha 1 Antitrypsin Goat anti-Human Polyclonal (aa230-241) Antibody
Human
Peptide-ELISA, WB
Unconjugated
100 µg/$503
SERPINA1 / Alpha 1 Antitrypsin Goat anti-Pig Polyclonal Antibody
Pig
ELISA, IE
Unconjugated
1 ml/$558
SERPINA1 / Alpha 1 Antitrypsin Rabbit anti-Human Monoclonal (Preservative Free) (005) Antibody
Human
ELISA
Unconjugated, Preservative Free
20 µl/$271; 100 µl/$412
SERPINA1 / Alpha 1 Antitrypsin Mouse anti-Human Monoclonal (OTI8E3) Antibody
Human
IHC, IHC-P, IP, WB
Unconjugated
100 µl/$434
SERPINA1 / Alpha 1 Antitrypsin Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
SERPINA1 / Alpha 1 Antitrypsin Mouse anti-Human Monoclonal (Preservative Free) Antibody
Human
ELISA, WB
Unconjugated, Preservative Free
20 µg/$242; 100 µg/$304; 200 µg/$334; 500 µg/$452
SERPINA1 / Alpha 1 Antitrypsin Mouse anti-Human Monoclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
250 µg/$755
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product results
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