Rho Kinase / ROCK1

Rho-associated, coiled-coil containing protein kinase 1

Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress. Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Required for centrosome positioning and centrosome-dependent exit from mitosis. Plays a role in terminal erythroid differentiation. May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles. Promotes keratinocyte terminal differentiation. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization.

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Antibodies (35)

ELISA Kits (5)

Proteins (4)

Type

Custom (3)

Over-Expression Lysate (2)

Primary (35)

Recombinant (2)

Sandwich (2)

Target

Rho Kinase / ROCK1 (44)

Reactivity

Human (35)

Mouse (26)

Rat (18)

Bat (1)

Bovine (3)

Dog (1)

Horse (1)

Monkey (3)

Pig (1)

Rabbit (1)

Application

IHC (11)

IHC-P (4)

WB (31)

Flo (1)

ELISA (6)

ICC (5)

IF (5)

IP (6)

Peptide-ELISA (1)

Host

rabbit (31)

mouse (4)

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IHCPlus (1)

Isotype

IgG (19)

IgG1 (2)

IgG1,k (1)

Clonality

monoclonal mc (6)

polyclonal pc (29)

Clone

154C1465 (1)

1H4 (2)

2E2 (1)

Format

96-Well Strip Plate (5)

APC (1)

APC Conjugated (1)

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Preservative Free (1)

Unconjugated (28)

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Epitope

aa1094-1323 (8)

Internal (2)

Asn311 (1)

Ser282 (1)

Tyr913 (1)

aa107-371 (1)

aa1114-1126 (1)

aa1300-C-term (1)

aa262-311 (1)

aa400-450 (1)

Publications

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Yes (1)

Sample Type

Plasma (2)

Serum (2)

Tissue Homogenates (1)

Tag

6His, N-terminus (1)

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Mouse (1)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

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IHC-plus™ Rho Kinase / ROCK1 Antibody LS-B7100

(4.0) Rating

Antibody:

Rho Kinase / ROCK1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

0.05 mg/$460

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Rho Kinase / ROCK1 Antibody LS-C497794

Antibody:

Rho Kinase / ROCK1 Rabbit anti-Human Monoclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Flo, IF, IHC, IP, WB

Format:

Unconjugated

Price:

20 µl/$299; 100 µl/$431

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Rho Kinase / ROCK1 Antibody (clone 2E2) LS-C198099

Antibody:

Rho Kinase / ROCK1 Mouse anti-Human Monoclonal (2E2) Antibody

Reactivity:

Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

100 µg/$423

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Rho Kinase / ROCK1 Antibody (clone 1H4) LS-C169453

Antibody:

Rho Kinase / ROCK1 Mouse anti-Human Monoclonal (1H4) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µl/$459

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Rho Kinase / ROCK1 Antibody LS-C75509

Antibody:

Rho Kinase / ROCK1 Rabbit anti-Human Monoclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IP, WB

Format:

Unconjugated

Price:

20 µl/$453; 100 µl/$643

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Rho Kinase / ROCK1 Antibody (aa1114-1126, clone 154C1465) LS-C511

Antibody:

Rho Kinase / ROCK1 Mouse anti-Human Monoclonal (aa1114-1126) (154C1465) Antibody

Reactivity:

Mouse, Dog, Bovine, Rat, Horse, Bat, Human, Monkey

Applications:

WB

Format:

Unconjugated

Price:

0.1 mg/$386

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Rho Kinase / ROCK1 Antibody (aa107-371) LS-C186291

Antibody:

Rho Kinase / ROCK1 Rabbit anti-Human Polyclonal (aa107-371) Antibody

Reactivity:

Human

Applications:

ICC, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$450

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Rho Kinase / ROCK1 Antibody (Internal) LS-C385933

Antibody:

Rho Kinase / ROCK1 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

ELISA, ICC, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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Human Rho Kinase / ROCK1 (Sandwich ELISA) ELISA Kit - LS-F66732

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.625 - 40 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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Mouse Rho Kinase / ROCK1 Protein (Recombinant 6His, N-terminus) (aa1094-1323) - LS-G25506

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

29.9 kDa

Price:

10 µg/$282; 50 µg/$447; 100 µg/$715; 200 µg/$892; 1 mg/$2,005; 500 µg/$1,543; 5 mg/$3,123; 2 mg/$2,192

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Rat Rho Kinase / ROCK1 (Sandwich ELISA) ELISA Kit - LS-F32208

(4.2) Rating

(3) Publication(s)

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

125 - 8000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Rho Kinase / ROCK1 Antibody LS-C408278

Antibody:

Rho Kinase / ROCK1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IP, WB

Format:

Unconjugated

Price:

20 µl/$287; 100 µl/$431

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Rho Kinase / ROCK1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G115988

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

158.6 kDa

Price:

100 µg/$710

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Rho Kinase / ROCK1 Antibody (Internal) LS-C352778

Antibody:

Rho Kinase / ROCK1 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Rabbit, Mouse, Bovine, Rat, Pig, Human, Monkey

Applications:

ICC, IF, WB

Format:

Unconjugated

Price:

100 µl/$299

Select

Rho Kinase / ROCK1 Antibody LS-C660577

Antibody:

Rho Kinase / ROCK1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$341

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Rho Kinase / ROCK1 Antibody LS-C660578

Antibody:

Rho Kinase / ROCK1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$341

Select

Rho Kinase / ROCK1 Antibody LS-C820531

Antibody:

Rho Kinase / ROCK1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ICC, IF

Format:

Unconjugated

Price:

100 µl/$412

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Rho Kinase / ROCK1 Antibody (aa262-311) LS-C291734

Antibody:

Rho Kinase / ROCK1 Rabbit anti-Human Polyclonal (aa262-311) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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Rho Kinase / ROCK1 Antibody (Asn311) LS-C177597

Antibody:

Rho Kinase / ROCK1 Rabbit anti-Human Polyclonal (Asn311) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

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Rho Kinase / ROCK1 Antibody LS-C772827

Antibody:

Rho Kinase / ROCK1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

60 µl/$343; 120 µl/$427; 200 µl/$559

Select

Rho Kinase / ROCK1 Antibody LS-C770312

Antibody:

Rho Kinase / ROCK1 Rabbit anti-Mouse Polyclonal Antibody

Reactivity:

Mouse, Rat

Applications:

IHC

Format:

Unconjugated

Price:

60 µl/$307; 120 µl/$367; 200 µl/$457

Select

Rho Kinase / ROCK1 Antibody (aa1300-C-term) LS-C287341

Antibody:

Rho Kinase / ROCK1 Rabbit anti-Human Polyclonal (aa1300-C-term) Antibody

Reactivity:

Mouse, Human

Applications:

IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

Rho Kinase / ROCK1 Antibody LS-C746275

Antibody:

Rho Kinase / ROCK1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$448

Select

Rho Kinase / ROCK1 Antibody (aa1094-1323) LS-C374823

Antibody:

Rho Kinase / ROCK1 Rabbit anti-Mouse Polyclonal (aa1094-1323) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261

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Rho Kinase / ROCK1 Antibody (clone 1H4) LS-C759699

Antibody:

Rho Kinase / ROCK1 Mouse anti-Human Monoclonal (1H4) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µg/$503

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