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Requiem / DPF2 is a member of the d4 domain family, characterized by a zinc finger-like structural motif. This protein functions as a transcription factor which is necessary for the apoptotic response following deprivation of survival factors. It likely serves a regulatory role in rapid hematopoietic cell growth and turnover. This gene is considered a candidate gene for multiple endocrine neoplasia type I, an inherited cancer syndrome involving multiple parathyroid, enteropancreatic, and pituitary tumors.
Gene Name: | D4, zinc and double PHD fingers family 2 |
Synonyms: | DPF2, BAF45D, REQ, UBID4, Zinc finger protein ubi-d4, BRG1-associated factor 45D, Ubi-d4, Protein requiem, Requiem |
Target Sequences: | NM_006268 NP_006259.1 Q92785 |
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