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Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.
Gene Name: | retinoblastoma binding protein 4 |
Synonyms: | RBBP4, CAF-I p48, CAF-1 subunit C, CAF-I 48 kDa subunit, MSI1 protein homolog, Histone-binding protein RBBP4, NURF55, RBBP-4, RBAP48 |
Target Sequences: | NM_005610 NP_005601.1 Q09028 |
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