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PSEN2 / Presenilin 2
presenilin 2 (Alzheimer disease 4)
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified.
| Gene Name: | presenilin 2 (Alzheimer disease 4) |
| Family/Subfamily: | Protease , Aspartic A22A |
| Synonyms: | PSEN2, AD3LP, AD4, AD5, AD3L, CMD1V, PS-2, PSNL2, PS2, STM2, Presenilin 2, STM-2, E5-1, Presenilin-2 |
| Target Sequences: | NM_000447 NP_000438.2 P49810 |
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Products
Antibodies
(29)
Type
Primary
(29)
Target
PSEN2 / Presenilin 2
(29)
Reactivity
Human
(29)
Mouse
(16)
Rat
(18)
Bat
(6)
Bovine
(6)
Chicken
(3)
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(3)
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(3)
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(6)
Guinea pig
(6)
Hamster
(6)
Horse
(6)
Monkey
(7)
Orangutan
(6)
Pig
(6)
Rabbit
(6)
Zebrafish
(3)
Application
IHC
(16)
IHC-Fr
(2)
IHC-P
(9)
WB
(22)
Flo
(1)
ELISA
(10)
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(4)
Peptide-ELISA
(2)
Host
rabbit
(27)
mouse
(1)
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(1)
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(1)
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IgG
(19)
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(1)
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(1)
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monoclonal mc
(1)
polyclonal pc
(28)
Clone
198C679.2.
(1)
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Biotin Conjugated
(3)
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(3)
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(3)
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(1)
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(1)
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(18)
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aa101-150
(4)
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(4)
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(3)
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(1)
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(1)
aa275-325
(1)
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(1)
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(1)
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(1)
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(1)
Publications
No
(29)
PSEN2 / Presenilin 2 Rabbit anti-Human Polyclonal (aa32-65) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
PSEN2 / Presenilin 2 Rabbit anti-Human Polyclonal (aa275-325) Antibody
Human
IHC, IHC-P, IP, WB
Unconjugated
50 µl/$460
PSEN2 / Presenilin 2 Rabbit anti-Human Polyclonal (aa330) Antibody
Mouse, Rat, Human, Monkey
ELISA, IHC, IHC-P, IP, WB
Unconjugated
100 µl/$688
PSEN2 / Presenilin 2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$832
PSEN2 / Presenilin 2 Rabbit anti-Human Polyclonal (aa39-51) Antibody
Mouse, Rat, Human
IHC, IHC-Fr, IHC-P, WB
Unconjugated
100 µg/$575
PSEN2 / Presenilin 2 Rabbit anti-Human Polyclonal (aa319-334) Antibody
Rat, Human
IHC, IHC-Fr, IHC-P, WB
Unconjugated
100 µg/$380
PSEN2 / Presenilin 2 Rabbit anti-Human Polyclonal (270-350 aa) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
PSEN2 / Presenilin 2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
PSEN2 / Presenilin 2 Rabbit anti-Human Polyclonal (aa101-150) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$424
PSEN2 / Presenilin 2 Rabbit anti-Human Polyclonal (aa101-150) (HRP) Antibody
Chicken, Bovine, Rabbit, Mouse, Dog, Guinea pig, Rat, Hamster, Pig, Horse, Bat, Gibbon, Orangutan, Human, Monkey
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
PSEN2 / Presenilin 2 Rabbit anti-Human Polyclonal (aa101-150) (Biotin) Antibody
Chicken, Bovine, Rabbit, Mouse, Dog, Guinea pig, Rat, Hamster, Pig, Horse, Bat, Gibbon, Orangutan, Human, Monkey
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
PSEN2 / Presenilin 2 Rabbit anti-Human Polyclonal (aa101-150) (FITC) Antibody
Chicken, Bovine, Rabbit, Mouse, Dog, Guinea pig, Rat, Hamster, Pig, Horse, Bat, Gibbon, Orangutan, Human, Monkey
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
PSEN2 / Presenilin 2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
PSEN2 / Presenilin 2 Chicken anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
500 µg/$729
PSEN2 / Presenilin 2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
100 µg/$341
PSEN2 / Presenilin 2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
PSEN2 / Presenilin 2 Rabbit anti-Human Polyclonal (pSer330) Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA
Unconjugated
50 µl/$334; 100 µl/$397
PSEN2 / Presenilin 2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
40 µg/$485
PSEN2 / Presenilin 2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$294; 100 µg/$360
PSEN2 / Presenilin 2 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
PSEN2 / Presenilin 2 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
PSEN2 / Presenilin 2 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA
FITC Conjugated
50 µg/$294; 100 µg/$360
PSEN2 / Presenilin 2 Mouse anti-Human Monoclonal (198C679.2.) Antibody
Human
WB
Unconjugated
200 µl/$386
PSEN2 / Presenilin 2 Rabbit anti-Human Polyclonal (aa318-367) Antibody
Human
WB
Unconjugated
100 µl/$424
PSEN2 / Presenilin 2 Rabbit anti-Human Polyclonal (aa318-367) (Biotin) Antibody
Zebrafish, Rat, Hamster, Rabbit, Mouse, Guinea pig, Bovine, Pig, Horse, Bat, Gibbon, Orangutan, Human, Monkey, Chimpanzee
WB
Biotin Conjugated
100 µl/$469
Viewing 1-25
of 29
product results
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