Human PSEN2 / Presenilin 2

Rabbit

Human, Mouse, Rat (tested or 100% immunogen sequence identity)

IgG Polyclonal

Unconjugated

Immunoaffinity purified

Unmodified

Synthetic peptide from the N-Terminus of human Presenilin 2(EDGENTAQWRSQE, aa39-51 of UniProt P49810). Percent identity by BLAST analysis: Human, Rat (100%); Mouse, Bovine, Hamster, Elephant, Dog (85%).

aa39-51

Human PSEN2 / Presenilin 2

• IHC
• IHC - Paraffin (0.5 - 1 µg/ml)
• IHC - Frozen (0.5 - 1 µg/ml)
• Western blot (0.5 - 1 µg/ml)

Presenilin-2 is a protein that in humans is encoded by the PSEN2 gene. Kovacs et al. (1996) demonstrated that the expression patterns of PS1 and PS2 in the brain are extremely similar to each other and that messages for both are primarily detectable in neuronal populations. Immunochemical analyses indicated that PS1 and PS2 are similar in size and localize to similar intracellular compartments (endoplasmic reticulum and Golgi complex). Li et al. (1997) demonstrated that wildtype PS1 and PS2 are localized to the nuclear membrane, its associated interphase kinetochores, and the centrosomes.In melanocytic cells PSEN2 gene expression may be regulated by MITF.

Lyophilized from PBS, 2.5% BSA, 0.025% sodium azide/thimerosal.

Reconstitute in sterile distilled water.

Prior to reconstitution, 4°C. Following reconstitution store at -20°C. Avoid freeze-thaw cycles.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P49810 NCBI: NM_000447 NP_000438.2