PRKAG1 / AMPK Gamma 1

protein kinase, AMP-activated, gamma 1 non-catalytic subunit

AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.

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Products

Proteins (8)

Type

Over-Expression Lysate (2)

Recombinant (6)

Target

PRKAG1 / AMPK Gamma 1 (8)

Publications

No (8)

Tag

GST (1)

His (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (7)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

Insect Cells (2)

Wheat Germ Extract (1)

Purification

Purified (4)

Low Endotoxin Level

Low endotoxin level (2)

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Human PRKAG1 / AMPK Gamma 1 Protein (Recombinant His) - LS-G2556

Source:

E. coli

Tag:

His

Price:

50 µg/$361; 250 µg/$739; 10 µg/$261

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Human PRKAG1 / AMPK Gamma 1 Protein (Recombinant GST) (Full Length) - LS-G29900

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

62.04 kDa

Price:

10 µg/$479; 25 µg/$670

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Human PRKAG1 / AMPK Gamma 1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G64761

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

28.1 kDa

Price:

20 µg/$1,107

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PRKAG1 / AMPK Gamma 1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99845

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

37.4 kDa

Price:

100 µg/$494

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Human PRKAG1 / AMPK Gamma 1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74106

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

37.4 kDa

Price:

20 µg/$150

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Human PRKAG1 / AMPK Gamma 1 Protein (Recombinant) (Met1-Pro331) - LS-G140820

Source:

Insect Cells

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

160 kDa

Price:

50 µg/$1,133

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Human PRKAG1 / AMPK Gamma 1 Protein (Recombinant) (Met1-Pro331) - LS-G140819

Source:

Insect Cells

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

158 kDa

Price:

50 µg/$1,133

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Human PRKAG1 / AMPK Gamma 1 Protein (Recombinant His-T7) (aa70-300) - LS-G15279

Source:

E. coli

Tag:

His-T7

Molecular Weight:

30.6 kDa

Price:

10 µg/$281; 50 µg/$440; 100 µg/$702; 200 µg/$877; 1 mg/$1,983; 500 µg/$1,523; 5 mg/$3,067; 2 mg/$2,170

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