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PRF1 / Perforin
perforin 1 (pore forming protein)
Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. in transplant rejection or some forms of autoimmune disease. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes.
| Gene Name: | perforin 1 (pore forming protein) |
| Synonyms: | PRF1, HPLH2, Perforin, p1, Perforin1, PFP, Cytolysin, FLH2, Perforin-1 |
| Target Sequences: | NM_005041 NP_005032.2 P14222 |
Publications (2)
1
Different NK cell-activating receptors preferentially recruit Rab27a or Munc13-4 to perforin-containing granules for cytotoxicity. Wood SM, Meeths M, Chiang SC, Bechensteen AG, Boelens JJ, Heilmann C, Horiuchi H, Rosthj S, Rutynowska O, Winiarski J, Stow JL, Nordenskjld M, Henter JI, Ljunggren HG, Bryceson YT. Blood. 2009 114:4117-27.
[PubMed:19704116]
2
Anti-PD-L1 prolongs survival and triggers T cell but not humoral anti-tumor immune responses in a human MUC1-expressing preclinical ovarian cancer model. Mony JT, Zhang L, Ma T, Grabosch S, Tirodkar TS, Brozick J, Tseng G, Elishaev E, Edwards RP, Huang X, Vlad AM. Cancer immunology, immunotherapy : CII. 2015 September;64:1095-108. [Full Text Article]
[PubMed:25998800]
[PMC:PMC4545381]
Related Antibodies: LS-C18632.
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PRF1 / Perforin
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(66)
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PRF1 / Perforin Rat anti-Mouse Monoclonal (CB5.4) Antibody
Mouse
ICC, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
100 µg/$508
PRF1 / Perforin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
PRF1 / Perforin Mouse anti-Human Monoclonal (delta G9) Antibody
Human
Flo, IHC, IHC-Fr
Unconjugated
100 µg/$446
PRF1 / Perforin Mouse anti-Human Monoclonal (Biotin) (delta G9) Antibody
Human
Flo, IHC, IHC-Fr
Biotin Conjugated
100 µg/$536
PRF1 / Perforin Mouse anti-Human Monoclonal (FITC) (delta G9) Antibody
Human
Flo, IHC, IHC-Fr
FITC Conjugated
120 Tests/$536
PRF1 / Perforin Mouse anti-Human Monoclonal (RPE) (delta G9) Antibody
Human
Flo, IHC, IHC-Fr
RPE Conjugated
120 Tests/$561
PRF1 / Perforin Mouse anti-Human Monoclonal (aa461-555) (3B4) Antibody
Human
ELISA, IP, WB
Unconjugated
100 µg/$423
PRF1 / Perforin Mouse anti-Human Monoclonal (5B10) Antibody
Human
IHC, IHC-Fr, IHC-P
Unconjugated
0.1 ml/$348
PRF1 / Perforin Mouse anti-Human Monoclonal (Ready-to-Use) (5B10) Antibody
Human
IHC-Fr, IHC-P
Unconjugated, Ready-to-Use
3 ml/$358
PRF1 / Perforin Mouse anti-Human Monoclonal (BOR21) Antibody
Human
WB
Unconjugated
100 µg/$442
PRF1 / Perforin Mouse anti-Human Monoclonal (dG9) Antibody
Bovine, Human
Flo, ICC, IHC-Fr, IHC-P, IP
Unconjugated
0.1 mg/$316
PRF1 / Perforin Mouse anti-Human Monoclonal (PE) (dG9) Antibody
Bovine, Human
Flo, ICC, IHC-Fr, IHC-P, IP
PE Conjugated
100 Tests/$365
PRF1 / Perforin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µl/$334; 100 µl/$397
PRF1 / Perforin Rabbit anti-Rat Polyclonal (aa120-353) Antibody
Rat
IHC, IHC-P, WB
Unconjugated
50 µl/$460
PRF1 / Perforin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$294; 100 µg/$360
PRF1 / Perforin Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
PRF1 / Perforin Mouse anti-Human Monoclonal (Biotin) Antibody
Human
Flo
Biotin Conjugated
100 µg/$763
PRF1 / Perforin Rabbit anti-Human Polyclonal (aa9-214) Antibody
Human
WB
Unconjugated
100 µl/$450
PRF1 / Perforin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
PRF1 / Perforin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
PRF1 / Perforin Mouse anti-Human Monoclonal (Concentrated) (MRQ-23) Antibody
Human
IHC, IHC-Fr, IHC-P
Unconjugated, Concentrated
1 ml/$1,216
PRF1 / Perforin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
PRF1 / Perforin Mouse anti-Human Monoclonal (C-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
500 µl/$939
PRF1 / Perforin Mouse anti-Human Monoclonal Antibody
Human
Flo, IP
Unconjugated
100 µg/$626
PRF1 / Perforin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$351
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