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Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
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PR / Progesterone Receptor
progesterone receptor
The progesterone receptor, a NR3 Steroid Receptor, is induced in granulosa cells of preovulatory follicles in response to surges in luteinizing hormone. It is essential for ovulation and egg implantation. A decrease in expression of endometrial progesterone receptor results in infertility in women. This receptor mediates the progesterone-induced transcription of proteases including ADAMTS1 and cathepsin L. In breast cancer, progesterone receptors are associated with hormone dependence and prolonged survival. At least two alternatively spliced isoforms have been identified in human: hPR-A (94 kD) is 164 aa shorter than hPR-B (114 kD). In most cell contexts, hPR-B functions as a transcriptional activator of progesterone-responsive genes, whereas hPR-A functions as a transcriptional inhibitor of all steroid hormone receptors. hPR-A and hPR-B have been shown to regulate different sets of genes in human breast cancer cells. Some of these PR-regulated genes are implicated in breast cancer.
| Gene Name: | progesterone receptor |
| Family/Subfamily: | NHR , NR3 Steroid receptor |
| Synonyms: | PGR, NR3C3, PR, Progesterone receptor |
| Target Sequences: | NM_000926 AAS00096.1 P06401 |
Publications (6)
1
Multiplexed assessment of the Southwest Oncology Group-directed Intergroup Breast Cancer Trial S9313 by AQUA shows that both high and low levels of HER2 are associated with poor outcome. Harigopal M, Barlow WE, Tedeschi G, Porter PL, Yeh IT, Haskell C, Livingston R, Hortobagyi GN, Sledge G, Shapiro C, Ingle JN, Rimm DL, Hayes DF. The American journal of pathology. 2010 176:1639-47. (IHC)
[PubMed:20150438]
[PMC:PMC2843456]
2
Evaluation of uterine receptivity after gonadotropin releasing hormone agonist administration as an oocyte maturation trigger: a rodent model. Ezoe K, Murata N, Yabuuchi A, Kobayashi T, Kato K. Scientific reports. 2019 August;9:12519. [Full Text Article]
[PubMed:31467307]
[PMC:PMC6715633]
3
Immunohistochemistry in Investigative and Toxicologic Pathology. Kyathanahalli S Janardhan, Heather Jensen, Natasha P Clayton, Ronald A Herbert. Toxicologic pathology. 2018 July;46:488-510. [Full Text Article]
[PubMed:29966501]
[PMC:PMC6033701]
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![PR / Progesterone Receptor Antibody - Immunoperoxidase of monoclonal antibody to PGR on formalin-fixed paraffin-embedded human breast cancer. [antibody concentration 3 ug/ml]](https://lsbio-7d62.kxcdn.com/image2/pr-progesterone-receptor-antibody-clone-4e9-ls-c133381/51454_4954690.jpg)
PR / Progesterone Receptor Mouse anti-Human Monoclonal (4E9) Antibody
Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
100 µg/$423
PR / Progesterone Receptor Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µl/$485
Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$798
Sandwich
96-Well Microplate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
PR / Progesterone Receptor Rabbit anti-Human Monoclonal (Concentrated) (Y85) Antibody
Human
IHC, IHC-Fr, IHC-P
Unconjugated, Concentrated
1 ml/$2,153
PR / Progesterone Receptor Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
30 µl/$255; 100 µl/$299; 200 µl/$351
Sandwich
12 x 8-Well Microstrips
Mouse
0.16 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
PR / Progesterone Receptor Rabbit anti-Human Polyclonal (aa595-933) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
PR / Progesterone Receptor Mouse anti-Human Monoclonal (aa919-933) (C262) Antibody
Chicken, Bovine, Rabbit, Mouse, Dog, Rat, Horse, Human, Monkey
IP, WB
Unconjugated
0.05 mg/$429
PR / Progesterone Receptor Mouse anti-Human Monoclonal (aa1-298) (Carrier-free) (OTI11E8) Antibody
Human
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
![PR / Progesterone Receptor Antibody - Immunoperoxidase of monoclonal antibody to PGR on formalin-fixed paraffin-embedded human endometrium. [antibody concentration 1.5 ug/ml]](https://lsbio-7d62.kxcdn.com/image2/pr-progesterone-receptor-antibody-clone-2c2-ls-c133378/51442_4954676.jpg)
PR / Progesterone Receptor Mouse anti-Human Monoclonal (2C2) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
100 µg/$423
PR / Progesterone Receptor Rabbit anti-Mouse Polyclonal (aa201-250) Antibody
Mouse
WB
Unconjugated
100 µl/$424
PR / Progesterone Receptor Mouse anti-Human Monoclonal (aa1-298) (OTI4B3) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
100 µl/$434
Sandwich
96-Well Strip Plate
Rat
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
E. coli
His, N-terminus
20.4 kDa
10 µg/$275; 50 µg/$402; 200 µg/$805; 100 µg/$645; 1 mg/$1,881; 500 µg/$1,435; 5 mg/$2,844; 2 mg/$2,065
PR / Progesterone Receptor Rabbit anti-Human Polyclonal (aa371-420) Antibody
Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
PR / Progesterone Receptor Rabbit anti-Human Polyclonal (aa261-310) Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA
Unconjugated
50 µl/$334; 100 µl/$397
PR / Progesterone Receptor Mouse anti-Human Monoclonal Antibody
Human
IHC, IHC-Fr, IHC-P
Unconjugated
0.1 ml/$371; 0.5 ml/$665; 1 ml/$952
PR / Progesterone Receptor Mouse anti-Human Monoclonal (pSer294) Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
100 µl/$469
![PR / Progesterone Receptor Antibody - Immunoperoxidase of monoclonal antibody to PGR on formalin-fixed paraffin-embedded human breast cancer. [antibody concentration 3 ug/ml]](https://lsbio-7d62.kxcdn.com/image2/pr-progesterone-receptor-antibody-clone-3e11-ls-c133377/51438_4954672.jpg)
PR / Progesterone Receptor Mouse anti-Human Monoclonal (3E11) Antibody
Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
100 µg/$423
![PR / Progesterone Receptor Antibody - Immunoperoxidase of monoclonal antibody to PGR on formalin-fixed paraffin-embedded human endometrium. [antibody concentration 1.5 ug/ml]](https://lsbio-7d62.kxcdn.com/image2/pr-progesterone-receptor-antibody-clone-1b11-ls-c133379/51446_4954677.jpg)
PR / Progesterone Receptor Mouse anti-Human Monoclonal (1B11) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
100 µg/$423
PR / Progesterone Receptor Rabbit anti-Human Polyclonal (Internal) Antibody
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$321
PR / Progesterone Receptor Rabbit anti-Human Polyclonal (pSer190) Antibody
Human, Monkey
ICC, IF, IHC, IHC-P, IP, WB
Unconjugated
30 µl/$263; 100 µl/$315; 200 µl/$379
![PR / Progesterone Receptor Antibody - Immunoperoxidase of monoclonal antibody to PGR on formalin-fixed paraffin-embedded human breast cancer. [antibody concentration 3 ug/ml]](https://lsbio-7d62.kxcdn.com/image2/pr-progesterone-receptor-antibody-clone-5d10-ls-c133380/51449_4954683.jpg)
PR / Progesterone Receptor Mouse anti-Human Monoclonal (5D10) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
100 µg/$423
PR / Progesterone Receptor Rabbit anti-Human Monoclonal (Ready-to-Use) (EP2) Antibody
Human
IHC-Fr, IHC-P
Unconjugated, Ready-to-Use
3 ml/$463; 7 ml/$709; 15 ml/$1,139
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