PPP1CA / PP1-Alpha

protein phosphatase 1, catalytic subunit, alpha isozyme

Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca2+/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E.

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Products

Proteins (9)

Type

Over-Expression Lysate (4)

Recombinant (5)

Target

PPP1CA / PP1-Alpha (9)

Publications

No (9)

Tag

10His, N-terminus + Myc, C-terminus (1)

6His, N-terminus (1)

GST (1)

GST, N-terminus (1)

His-T7 (1)

Myc-DDK (Flag) (4)

Species

Dog (1)

Human (6)

Source

293T Cells (2)

E. coli (3)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (3)

Biologically Active

Biologically active (1)

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Human PPP1CA / PP1-Alpha Protein (Recombinant 6His, N-terminus) - LS-G1397

Source:

E. coli

Tag:

6His, N-terminus

Biological Activity:

Biologically active

Price:

10 µg/$361; 50 µg/$739

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Human PPP1CA / PP1-Alpha Protein (Recombinant GST) (Full Length) - LS-G29843

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

61.93 kDa

Price:

10 µg/$479; 25 µg/$670

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Human PPP1CA / PP1-Alpha Protein (Recombinant GST, N-terminus) (aa224-330) - LS-G59685

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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PPP1CA / PP1-Alpha Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99840

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

37.3 kDa

Price:

100 µg/$494

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Human PPP1CA / PP1-Alpha Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78748

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

38.5 kDa

Price:

20 µg/$150

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Human PPP1CA / PP1-Alpha Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78749

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

37.3 kDa

Price:

20 µg/$150

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PPP1CA / PP1-Alpha Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G121860

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

38.5 kDa

Price:

100 µg/$494

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Dog PPP1CA / PP1-Alpha Protein (Recombinant 10His, N-terminus + Myc, C-terminus) (Full Length) - LS-G136505

Source:

E. coli

Tag:

10His, N-terminus + Myc, C-terminus

Molecular Weight:

42.3 kDa

Price:

1 mg/$1,486; 100 µg/$451; 20 µg/$339

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Human PPP1CA / PP1-Alpha Protein (Recombinant His-T7) (aa2-330) - LS-G24680

Source:

E. coli

Tag:

His-T7

Molecular Weight:

41.1 kDa

Price:

10 µg/$274; 50 µg/$400; 100 µg/$637; 200 µg/$797; 1 mg/$1,870; 500 µg/$1,424; 5 mg/$2,832; 2 mg/$2,053

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