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PP2Ac / PPP2CA
protein phosphatase 2, catalytic subunit, alpha isozyme
Protein phosphatase 2A alpha (PPP2CA), is a PP2A type serine/threonine phosphatase. PP2A members are composed of a common heterodimeric core enzyme (a catalytic subunit C and a constant regulatory subunit PR65 or A) that associates with a wide variety of regulatory subunits (subunit B). PPP2CA is a catalytic subunit that plays a role in transcription, translation, cell cycle control, and the regulation of most major metabolic pathways. Additionally, it may function as a tumor promoter or suppressor depending on the cell type or the transforming agent.
| Gene Name: | protein phosphatase 2, catalytic subunit, alpha isozyme |
| Family/Subfamily: | Protein Phosphatase , PP2A |
| Synonyms: | PPP2CA, PP2Ac, PP2Calpha, ppp2A1, Protein phosphatase 2A alpha, Replication protein C, PP2CA, RP-C, PP2A-alpha |
| Target Sequences: | NM_002715 NP_002706.1 P67775 |
Publications (3)
1
The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein. Neviani P, Santhanam R, Trotta R, Notari M, Blaser BW, Liu S, Mao H, Chang JS, Galietta A, Uttam A, Roy DC, Valtieri M, Bruner-Klisovic R, Caligiuri MA, Bloomfield CD, Marcucci G, Perrotti D. Cancer cell. 2005 8:355-68. (IP)
[PubMed:16286244]
2
Genome-wide expression profiling reveals transcriptomic variation and perturbed gene networks in androgen-dependent and androgen-independent prostate cancer cells. Singh AP, Bafna S, Chaudhary K, Venkatraman G, Smith L, Eudy JD, Johansson SL, Lin MF, Batra SK. Cancer letters. 2008 259:28-38. (IHC, WB)
[PubMed:17977648]
[PMC:PMC2784916]
3
Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness. Li Gu, Yahui Zhu, Kosuke Watari, Maiya Lee, Junlai Liu, Sofia Perez, Melinda Thai, Joshua E Mayfield, Bichen Zhang, Karina Cunha E Rocha, Fuming Li, Laura C Kim, Alexander C Jones, Igor H Wierzbicki, Xiao Liu, Alexandra C Newton, Tatiana Kisseleva, Jun Hee Lee, Wei Ying, David J Gonzalez, Alan R Saltiel, M Celeste Simon, Michael Karin. Cell metabolism. 2023 June;35:1009-1021.e9. [Full Text Article]
[PubMed:37084733]
[PMC:PMC10430883]
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(67)
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Wheat Germ Extract
GST
62 kDa
10 µg/$479; 25 µg/$670
PP2Ac / PPP2CA Mouse anti-Human Monoclonal (P6C7) Antibody
Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50 µl/$460
PP2Ac / PPP2CA Rabbit anti-Human Polyclonal (aa1-309) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
PP2Ac / PPP2CA Rabbit anti-Human Polyclonal (aa296-309) Antibody
Rabbit, Mouse, Rat, Human
IP, WB
Unconjugated
200 µg/$854
PP2Ac / PPP2CA Rabbit anti-Human Polyclonal (p307) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$357
PP2Ac / PPP2CA Rabbit anti-Human Polyclonal (250-330 aa) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
PP2Ac / PPP2CA Rabbit anti-Human Polyclonal (aa1-30) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
PP2Ac / PPP2CA Mouse anti-Human Monoclonal Antibody
Human
ELISA, WB
Unconjugated
50 µl/$459; 100 µl/$688
PP2Ac / PPP2CA Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Chicken, Zebrafish, Pig, Rat, Bovine, Rabbit, Mouse, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$321
PP2Ac / PPP2CA Rabbit anti-Human Polyclonal (pTyr307) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$357
PP2Ac / PPP2CA Rabbit anti-Human Polyclonal (aa260-309) Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
PP2Ac / PPP2CA Rabbit anti-Human Polyclonal (pTyr307) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
PP2Ac / PPP2CA Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$331
PP2Ac / PPP2CA Rabbit anti-Human Polyclonal (250-330 aa) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
PP2Ac / PPP2CA Rabbit anti-Human Polyclonal (aa62-111) (Biotin) Antibody
Xenopus, Chicken, Drosophila, Rat, Hamster, Bat, Pig, Horse, Bovine, Rabbit, Mouse, Dog, Guinea pig, Human, Monkey, Gibbon, Chimpanzee
WB
Biotin Conjugated
100 µl/$469
PP2Ac / PPP2CA Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$460
PP2Ac / PPP2CA Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
ICC, IHC, IHC-P, WB
Unconjugated
100 µg/$564
PP2Ac / PPP2CA Rabbit anti-Human Polyclonal (Thr301) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
PP2Ac / PPP2CA Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
ICC, IHC, IHC-P, WB
Unconjugated
100 µg/$380
PP2Ac / PPP2CA Rabbit anti-Human Polyclonal (N-Terminus) (Magnetic beads) Antibody
Mouse, Rat, Human
IP
Magnetic beads Conjugated
100 µg/$399
PP2Ac / PPP2CA Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
PP2Ac / PPP2CA Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
PP2Ac / PPP2CA Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
PP2Ac / PPP2CA Rat anti-Human Monoclonal (aa209-309) Antibody
Human
IF, IHC, IHC-P
Unconjugated
100 µg/$872
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of 68
product results
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