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POU5F1 / OCT4
POU class 5 homeobox 1
POU5F1 / OCT4 is a transcription factor containing a POU homeodomain that plays a key role in embryonic development and stem cell pluripotency. Aberrant expression of this gene in adult tissues is associated with tumorigenesis. This gene can participate in a translocation with the Ewing's sarcoma gene on chromosome 21, which also leads to tumor formation. Alternative splicing, as well as usage of alternative AUG and non-AUG translation initiation codons, results in multiple isoforms. One of the AUG start codons is polymorphic in human populations. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12.
| Gene Name: | POU class 5 homeobox 1 |
| Synonyms: | POU5F1, Oct-4, OCT3, OCT4, OTF4, POU class 5 homeobox 1, Octamer-binding protein 3, Octamer-binding protein 4, OTF-3, Oct-3, OTF3, OCT3/4 |
| Target Sequences: | NM_002701 NP_002692.2 Q01860 |
Publications (3)
1
Endothelial progenitor cells restore renal function in chronic experimental renovascular disease. Chade AR, Zhu X, Lavi R, Krier JD, Pislaru S, Simari RD, Napoli C, Lerman A, Lerman LO. Circulation. 2009 119:547-57. (ICC, WB, IHC-P, IHC-Fr; Pig)
[PubMed:19153272]
[PMC:PMC2758066]
2
Stabilization of HIF-1a and HIF-2a, up-regulation of MYCC and accumulation of stabilized p53 constitute hallmarks of CNS-PNET animal model. Malchenko S, Sredni ST, Bi Y, Margaryan NV, Boyineni J, Mohanam I, Tomita T, Davuluri RV, Soares MB. PloS one. 2017 12:e0173106. (IHC, WB; Mouse)
[Full Text Article]
[PubMed:28249000]
[PMC:PMC5332108]
Related Antibodies: LS-B85.
3
Step-by-step protocols for non-viral derivation of transgene-free induced pluripotent stem cells from somatic fibroblasts of multiple mammalian species. Sho Yoshimatsu, Atsushi Yamazaki, Kazuya Edamura, Yuko Koushige, Hisashi Shibuya, Emi Qian, Tsukika Sato, Junko Okahara, Noriyuki Kishi, Toshiaki Noce, Yoshifumi Yamaguchi, Hideyuki Okano. Development, growth & differentiation. 2022 August;64:325-341. [Full Text Article]
[PubMed:35841539]
Related Antibodies: LS-B1194.
☰ Filters
Products
ELISA Kits
(14)
Type
Cell-Based
(1)
Custom
(3)
DNA Binding
(1)
Sandwich
(9)
Target
POU5F1 / OCT4
(14)
Reactivity
Human
(7)
Mouse
(5)
Rat
(3)
Pig
(1)
Rabbit
(1)
Format
12 x 8-Well Microstrips
(1)
96-Well Microplate
(4)
96-Well Strip Plate
(9)
Publications
No
(14)
Sample Type
Adherent Cell Cultures
(1)
Cell Culture Supernatants
(1)
Cell Lysates
(2)
Nuclear Lysates
(1)
Plasma
(7)
Serum
(7)
Tissue Homogenates
(5)
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
DNA Binding
12 x 8-Well Microstrips
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Cell Lysates, Nuclear Lysates
1 Plate/$694
Cell-Based
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$534
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Tissue Homogenates
1 Plate/$782
Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$669
Custom
96-Well Strip Plate
Pig
Colorimetric - 450nm (TMB)
1 Plate/$669
Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$669
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Sandwich
96-Well Strip Plate
Rabbit
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Sandwich
96-Well Microplate
Human
0.2 - 50 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$559
Sandwich
96-Well Microplate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$764
Sandwich
96-Well Microplate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
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