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POU5F1 / OCT4
POU class 5 homeobox 1
POU5F1 / OCT4 is a transcription factor containing a POU homeodomain that plays a key role in embryonic development and stem cell pluripotency. Aberrant expression of this gene in adult tissues is associated with tumorigenesis. This gene can participate in a translocation with the Ewing's sarcoma gene on chromosome 21, which also leads to tumor formation. Alternative splicing, as well as usage of alternative AUG and non-AUG translation initiation codons, results in multiple isoforms. One of the AUG start codons is polymorphic in human populations. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12.
| Gene Name: | POU class 5 homeobox 1 |
| Synonyms: | POU5F1, Oct-4, OCT3, OCT4, OTF4, POU class 5 homeobox 1, Octamer-binding protein 3, Octamer-binding protein 4, OTF-3, Oct-3, OTF3, OCT3/4 |
| Target Sequences: | NM_002701 NP_002692.2 Q01860 |
Publications (3)
1
Endothelial progenitor cells restore renal function in chronic experimental renovascular disease. Chade AR, Zhu X, Lavi R, Krier JD, Pislaru S, Simari RD, Napoli C, Lerman A, Lerman LO. Circulation. 2009 119:547-57. (ICC, WB, IHC-P, IHC-Fr; Pig)
[PubMed:19153272]
[PMC:PMC2758066]
2
Stabilization of HIF-1a and HIF-2a, up-regulation of MYCC and accumulation of stabilized p53 constitute hallmarks of CNS-PNET animal model. Malchenko S, Sredni ST, Bi Y, Margaryan NV, Boyineni J, Mohanam I, Tomita T, Davuluri RV, Soares MB. PloS one. 2017 12:e0173106. (IHC, WB; Mouse)
[Full Text Article]
[PubMed:28249000]
[PMC:PMC5332108]
Related Antibodies: LS-B85.
3
Step-by-step protocols for non-viral derivation of transgene-free induced pluripotent stem cells from somatic fibroblasts of multiple mammalian species. Sho Yoshimatsu, Atsushi Yamazaki, Kazuya Edamura, Yuko Koushige, Hisashi Shibuya, Emi Qian, Tsukika Sato, Junko Okahara, Noriyuki Kishi, Toshiaki Noce, Yoshifumi Yamaguchi, Hideyuki Okano. Development, growth & differentiation. 2022 August;64:325-341. [Full Text Article]
[PubMed:35841539]
Related Antibodies: LS-B1194.
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Antibodies
(113)
Type
Primary
(113)
Target
POU5F1 / OCT4
(113)
Reactivity
Human
(96)
Mouse
(38)
Rat
(15)
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(2)
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(1)
aa214-247
(1)
aa250-300
(1)
aa265-297
(1)
aa282-297
(1)
aa291-324
(1)
aa322-335
(1)
aa350-360
(1)
aa64-288
(1)
aa86-119
(1)
Publications
No
(111)
Yes
(2)
POU5F1 / OCT4 Rabbit anti-Human Polyclonal (aa100-200) Antibody
Mouse, Porcine, Human
Flo, ICC, IF, IHC, IHC-Fr, IHC-P, WB
Unconjugated
0.1 ml/$460
POU5F1 / OCT4 Rabbit anti-Human Polyclonal (Internal) (Biotin) Antibody
Mouse, Rat, Primate, Human
Flo, ICC, IF, IHC, IHC-P, IP, WB
Biotin Conjugated
0.1 ml/$416
POU5F1 / OCT4 Rabbit anti-Human Polyclonal (Internal) (DY488) Antibody
Human
Flo, ICC, IF, IHC, IHC-P, IP, WB
DY488 Conjugated
0.1 ml/$416
POU5F1 / OCT4 Rabbit anti-Human Polyclonal (Internal) (DY550) Antibody
Human
Flo, ICC, IF, IHC, IHC-P, IP, WB
DY550 Conjugated
0.1 ml/$416
POU5F1 / OCT4 Rabbit anti-Human Polyclonal (Internal) (DY650) Antibody
Human
Flo, ICC, IF, IHC, IHC-P, IP, WB
DY650 Conjugated
0.1 ml/$416
POU5F1 / OCT4 Rabbit anti-Human Polyclonal Antibody
Human
Flo, ICC, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$440
POU5F1 / OCT4 Rabbit anti-Human Polyclonal (aa114-163) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$460
POU5F1 / OCT4 Rabbit anti-Human Polyclonal (aa191-240) Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
POU5F1 / OCT4 Mouse anti-Human Monoclonal (OTI9B7) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
POU5F1 / OCT4 Mouse anti-Human Monoclonal (Carrier-free) (OTI9B7) Antibody
Human
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
POU5F1 / OCT4 Mouse anti-Human Monoclonal (7E7) Antibody
Human
ELISA, Flo, IF, WB
Unconjugated
100 µl/$435
POU5F1 / OCT4 Rabbit anti-Human Polyclonal (aa282-297) Antibody
Rodent, Human
ICC, IHC, WB
Unconjugated
100 µg/$872
POU5F1 / OCT4 Rabbit anti-Human Polyclonal (PE) Antibody
Rodent, Human
ICC, IHC, WB
PE Conjugated
100 µl/$1,089
POU5F1 / OCT4 Mouse anti-Human Monoclonal (Concentrated) (MRQ-10) Antibody
Human
IHC, IHC-Fr, IHC-P
Unconjugated, Concentrated
1 ml/$1,813
POU5F1 / OCT4 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Bovine, Rat, Pig, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$299
POU5F1 / OCT4 Mouse anti-Human Monoclonal (4H2) Antibody
Human
ELISA, Flo, IF, IHC, WB
Unconjugated
100 µl/$346
POU5F1 / OCT4 Mouse anti-Human Monoclonal Antibody
Human
Flo, ICC, IF, WB
Unconjugated
50 µl/$356; 100 µl/$461
POU5F1 / OCT4 Rabbit anti-Zebrafish Polyclonal (aa141-177) Antibody
Zebrafish
Peptide-ELISA, WB
Unconjugated
200 µl/$393
POU5F1 / OCT4 Mouse anti-Human Monoclonal Antibody
Human
ELISA, Flo, IF, WB
Unconjugated
50 µg/$332; 100 µg/$404; 200 µg/$505
POU5F1 / OCT4 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
WB
Unconjugated
100 µl/$450
POU5F1 / OCT4 Mouse anti-Human Monoclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$351
POU5F1 / OCT4 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$331
POU5F1 / OCT4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
POU5F1 / OCT4 Rabbit anti-Human Polyclonal (aa1-30) (FITC) Antibody
Human
ELISA, ICC, IF, WB
FITC Conjugated
200 µl/$952
POU5F1 / OCT4 Rabbit anti-Human Polyclonal (aa1-30) (APC) Antibody
Human
ELISA, ICC, IF, WB
APC Conjugated
200 µl/$952
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product results
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