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Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Required with its accessory proteins (proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved in completing Okazaki fragments initiated by the DNA polymerase alpha/primase complex.
Gene Name: | polymerase (DNA directed), delta 1, catalytic subunit |
Synonyms: | POLD1, CDC2, CDC2 homolog, POLD |
Target Sequences: | NM_002691 NP_002682.2 P28340 |
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