POLA1 / DNA Polymerase Alpha 1

polymerase (DNA directed), alpha 1, catalytic subunit

Plays an essential role in the initiation of DNA replication. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1/p180, a regulatory subunit POLA2/p70 and two primase subunits PRIM1/p49 and PRIM2/p58) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively. The reason this transfer occurs is because the polymerase alpha has limited processivity and lacks intrinsic 3' exonuclease activity for proofreading error, and therefore is not well suited for replicating long complexes.

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Products

Antibodies (30)

Proteins (3)

ELISA Kits (1)

Type

Cell-Based (1)

Primary (30)

Recombinant (3)

Target

POLA1 / DNA Polymerase Alpha 1 (34)

Reactivity

Human (23)

Mouse (10)

Application

IHC (1)

IHC-Fr (1)

WB (29)

Flo (1)

ELISA (5)

ICC (1)

IF (1)

IP (3)

Peptide-ELISA (2)

Host

rabbit (28)

mouse (2)

Isotype

Ig (2)

IgG (6)

IgG1 (1)

IgG2a,k (1)

Clonality

monoclonal mc (2)

polyclonal pc (28)

Clone

3C11 (1)

CL22-2-42B (1)

Format

96-Well Microplate (1)

APC (2)

APC Conjugated (2)

Biotin Conjugated (2)

Cy3 Conjugated (2)

Cy7 Conjugated (2)

FITC Conjugated (2)

HRP Conjugated (2)

PE Conjugated (2)

Unconjugated (16)

Epitope

aa1209-1465 (8)

aa1240-1462 (8)

N-Terminus (2)

50-130 aa, N-terminal (1)

C-Terminus (1)

Lys111 (1)

aa1175-1225 (1)

aa775-825 (1)

aa81-130 (1)

Publications

No (34)

Sample Type

Adherent Cell Cultures (1)

Tag

GST, N-terminus (1)

His, N-Terminal (1)

His-T7 (1)

Species

Human (2)

Mouse (1)

Source

E. coli (2)

Wheat Germ Extract (1)

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POLA1 / DNA Polymerase Alpha 1 Antibody (C-Terminus) LS-C757516

Antibody:

POLA1 / DNA Polymerase Alpha 1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$393

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POLA1 / DNA Polymerase Alpha 1 Antibody (Lys111) LS-C176726

Antibody:

POLA1 / DNA Polymerase Alpha 1 Rabbit anti-Human Polyclonal (Lys111) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

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POLA1 / DNA Polymerase Alpha 1 Antibody (clone CL22-2-42B) LS-C179886

Antibody:

POLA1 / DNA Polymerase Alpha 1 Mouse anti-Human Monoclonal (CL22-2-42B) Antibody

Reactivity:

Human

Applications:

Flo, ICC, IHC, IHC-Fr

Format:

Unconjugated

Price:

50 µl/$403

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Human POLA1 / DNA Polymerase Alpha 1 Protein (Recombinant His, N-Terminal) (aa1240-1462) - LS-G25047

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

29.5 kDa

Price:

10 µg/$279; 50 µg/$432; 200 µg/$862; 1 mg/$1,962; 5 mg/$3,011; 2 mg/$2,148

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POLA1 / DNA Polymerase Alpha 1 Antibody LS-C801349

Antibody:

POLA1 / DNA Polymerase Alpha 1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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POLA1 / DNA Polymerase Alpha 1 Antibody (clone 3C11) LS-C197940

Antibody:

POLA1 / DNA Polymerase Alpha 1 Mouse anti-Human Monoclonal (3C11) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$423

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POLA1 / DNA Polymerase Alpha 1 Antibody (50-130 aa, N-terminal) LS-C383157

Antibody:

POLA1 / DNA Polymerase Alpha 1 Rabbit anti-Human Polyclonal (50-130 aa, N-terminal) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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POLA1 / DNA Polymerase Alpha 1 Antibody (N-Terminus) LS-C757481

Antibody:

POLA1 / DNA Polymerase Alpha 1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$393

Select

POLA1 / DNA Polymerase Alpha 1 Antibody LS-C822575

Antibody:

POLA1 / DNA Polymerase Alpha 1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

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POLA1 / DNA Polymerase Alpha 1 Antibody (aa775-825) LS-C289559

Antibody:

POLA1 / DNA Polymerase Alpha 1 Rabbit anti-Human Polyclonal (aa775-825) Antibody

Reactivity:

Mouse, Human

Applications:

IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

POLA1 / DNA Polymerase Alpha 1 Antibody (aa1175-1225) LS-C289561

Antibody:

POLA1 / DNA Polymerase Alpha 1 Rabbit anti-Human Polyclonal (aa1175-1225) Antibody

Reactivity:

Human

Applications:

IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

POLA1 / DNA Polymerase Alpha 1 Antibody (aa81-130) LS-C118771

Antibody:

POLA1 / DNA Polymerase Alpha 1 Rabbit anti-Human Polyclonal (aa81-130) Antibody

Reactivity:

Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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POLA1 / DNA Polymerase Alpha 1 Antibody (N-Terminus) LS-C352673

Antibody:

POLA1 / DNA Polymerase Alpha 1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

IP, WB

Format:

Unconjugated

Price:

100 µl/$299

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POLA1 / DNA Polymerase Alpha 1 Antibody (aa1209-1465) LS-C374624

Antibody:

POLA1 / DNA Polymerase Alpha 1 Rabbit anti-Mouse Polyclonal (aa1209-1465) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261

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POLA1 / DNA Polymerase Alpha 1 Antibody (aa1209-1465, HRP) LS-C711835

Antibody:

POLA1 / DNA Polymerase Alpha 1 Rabbit anti-Mouse Polyclonal (aa1209-1465) (HRP) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$342; 200 µl/$398; 500 µl/$585; 1 ml/$722; 2 ml/$959; 5 ml/$1,639

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POLA1 / DNA Polymerase Alpha 1 Antibody (aa1209-1465, Biotin) LS-C687388

Antibody:

POLA1 / DNA Polymerase Alpha 1 Rabbit anti-Mouse Polyclonal (aa1209-1465) (Biotin) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$321; 200 µl/$369; 500 µl/$527; 1 ml/$611; 2 ml/$842; 5 ml/$1,387

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POLA1 / DNA Polymerase Alpha 1 Antibody (aa1209-1465, FITC) LS-C694211

Antibody:

POLA1 / DNA Polymerase Alpha 1 Rabbit anti-Mouse Polyclonal (aa1209-1465) (FITC) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$352; 200 µl/$412; 500 µl/$622; 1 ml/$777; 2 ml/$1,014; 5 ml/$1,765

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POLA1 / DNA Polymerase Alpha 1 Antibody (aa1209-1465, Cy3) LS-C702814

Antibody:

POLA1 / DNA Polymerase Alpha 1 Rabbit anti-Mouse Polyclonal (aa1209-1465) (Cy3) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Cy3 Conjugated

Price:

100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521

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POLA1 / DNA Polymerase Alpha 1 Antibody (aa1209-1465, PE) LS-C725897

Antibody:

POLA1 / DNA Polymerase Alpha 1 Rabbit anti-Mouse Polyclonal (aa1209-1465) (PE) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

PE Conjugated

Price:

100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521

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POLA1 / DNA Polymerase Alpha 1 Antibody (aa1209-1465, APC, Cy7) LS-C734843

Antibody:

POLA1 / DNA Polymerase Alpha 1 Rabbit anti-Mouse Polyclonal (aa1209-1465) (APC, Cy7) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

APC, Cy7 Conjugated

Price:

100 µl/$513; 200 µl/$666; 500 µl/$1,175; 1 ml/$1,441; 2 ml/$2,017; 5 ml/$3,781

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POLA1 / DNA Polymerase Alpha 1 Antibody (aa1209-1465, APC) LS-C740713

Antibody:

POLA1 / DNA Polymerase Alpha 1 Rabbit anti-Mouse Polyclonal (aa1209-1465) (APC) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

APC Conjugated

Price:

100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521

• Unconjugated
• HRP
• Biotin
• FITC
• Cy3
• PE
• APC, Cy7
• More...
  • APC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC
  • Cy3
  • PE
  • APC, Cy7
  • APC

Select

POLA1 / DNA Polymerase Alpha 1 Antibody LS-C417055

Antibody:

POLA1 / DNA Polymerase Alpha 1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

50 µg/$305; 100 µg/$357

Select

POLA1 / DNA Polymerase Alpha 1 Antibody LS-C356958

Antibody:

POLA1 / DNA Polymerase Alpha 1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$386

Select

POLA1 / DNA Polymerase Alpha 1 Antibody (aa1240-1462) LS-C374623

Antibody:

POLA1 / DNA Polymerase Alpha 1 Rabbit anti-Human Polyclonal (aa1240-1462) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225

Select

POLA1 / DNA Polymerase Alpha 1 Antibody (aa1240-1462, Biotin) LS-C687391

Antibody:

POLA1 / DNA Polymerase Alpha 1 Rabbit anti-Human Polyclonal (aa1240-1462) (Biotin) Antibody

Reactivity:

Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$319; 200 µl/$365; 500 µl/$519; 1 ml/$596; 2 ml/$824; 5 ml/$1,348

• Unconjugated
• Biotin

• Unconjugated
• Biotin

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