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PMEL / SILV / gp100
premelanosome protein
PMEL / SILV / gp100 is a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants.
| Gene Name: | premelanosome protein |
| Synonyms: | PMEL, gp100, Melanocyte protein PMEL, Me20m/me20s, p100, PMEL17, Premelanosome protein, SIL, Silver homolog (mouse), Silver, mouse, homolog of, Silver locus protein homolog, ME20-M, Me20-m/me20-s, ME20M, Melanocyte protein mel 17, Melanocyte protein Pmel 17, Silver (mouse homolog) like, D12S53E, ME20, Melanosomal matrix protein17, SILV |
| Target Sequences: | NM_006928 NP_008859.1 P40967 |
Publications (2)
1
Low-dose radiation treatment enhances systemic antitumor immune responses by overcoming the inhibitory stroma. Hampartsoum B Barsoumian, Rishab Ramapriyan, Ahmed I Younes, Mauricio S Caetano, Hari Menon, Nathan I Comeaux, Taylor R Cushman, Jonathan E Schoenhals, Alexandra P Cadena, Timothy P Reilly, Dawei Chen, Fatemeh Masrorpour, Ailin Li, David S Hong, Adi Diab, Quynh-Nhu Nguyen, Isabella Glitza, Renata Ferrarotto, Stephen G Chun, Maria Angelica Cortez, James Welsh. Journal for immunotherapy of cancer. 2020 October;8: [Full Text Article]
[PubMed:33106386]
[PMC:PMC7592253]
2
Landscape mapping of shared antigenic epitopes and their cognate TCRs of tumor-infiltrating T lymphocytes in melanoma. Kenji Murata , Munehide Nakatsugawa , Muhammed A Rahman, Linh T Nguyen, Douglas G Millar, David T Mulder, Kenji Sugata, Hiroshi Saijo, Yukiko Matsunaga, Yuki Kagoya, Tingxi Guo, Mark Anczurowski, Chung-Hsi Wang, Brian D Burt, Dalam Ly, Kayoko Saso, Alexandra Easson, David P Goldstein, Michael Reedijk, Danny Ghazarian, Trevor J Pugh, Marcus O Butler, Tak W Mak, Pamela S Ohashi, Naoto Hirano. eLife. 2020 Apr;9:e53244. [Full Text Article]
[PubMed:32314731]
[PMC:PMC7234812]
Related Antibodies: LS-C114528.
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Products
Antibodies
(69)
ELISA Kits
(14)
Proteins
(5)
Type
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(2)
Over-Expression Lysate
(1)
Primary
(69)
Recombinant
(4)
Sandwich
(11)
Sandwich CLIA
(1)
Target
PMEL / SILV / gp100
(88)
Reactivity
Human
(72)
Mouse
(8)
Rat
(9)
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(2)
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(3)
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(5)
Gibbon
(3)
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(4)
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(8)
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(4)
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(1)
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(1)
Application
IHC
(32)
IHC-Fr
(2)
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(32)
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(33)
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(15)
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(18)
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(23)
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rabbit
(22)
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(46)
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(22)
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(12)
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(16)
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(10)
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(4)
Clonality
monoclonal mc
(46)
polyclonal pc
(21)
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(2)
Clone
ABT-PMEL
(1)
HMB45 + PMEL/783
(3)
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(3)
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(2)
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(2)
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(2)
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(2)
PMEL/783
(3)
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(2)
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(2)
Format
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(1)
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(1)
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(12)
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(1)
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(13)
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(3)
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(10)
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(11)
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(3)
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(3)
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(1)
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(3)
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(58)
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aa25-467
(9)
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(7)
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(4)
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(2)
aa647-660
(1)
Publications
No
(86)
Yes
(2)
Sample Type
Cell Lysates
(2)
Plasma
(6)
Serum
(6)
Tissue Homogenates
(4)
Tag
6His-SUMO, N-terminus
(1)
GST
(1)
His
(1)
Myc-DDK (Flag)
(2)
Species
Human
(5)
Source
E. coli
(1)
HEK 293 Cells
(2)
Wheat Germ Extract
(1)
Yeast
(1)
Purification
Purified
(1)
PMEL / SILV / gp100 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
100 µl/$440
PMEL / SILV / gp100 Rabbit anti-Human Polyclonal (aa231-280) Antibody
Human
IHC, WB
Unconjugated
100 µl/$397
PMEL / SILV / gp100 Rabbit anti-Human Polyclonal (aa231-280) (Biotin) Antibody
Mouse, Rat, Chimpanzee, Gibbon, Human, Monkey
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$442
PMEL / SILV / gp100 Mouse anti-Human Monoclonal (aa25-467) (OTI1E5) Antibody
Human
WB
Unconjugated
100 µl/$434
PMEL / SILV / gp100 Mouse anti-Human Monoclonal (OTI7E3) Antibody
Human
Flo, IHC
Unconjugated
100 µl/$434
PMEL / SILV / gp100 Mouse anti-Human Monoclonal (OTI10E5) Antibody
Dog, Rat, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
Sandwich
96-Well Strip Plate
Mouse
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
Wheat Germ Extract
GST
96.7 kDa
2 µg/$439
E. coli
6His-SUMO, N-terminus
63 kD
100 µg/$420; 20 µg/$323; 1 mg/$1,355
PMEL / SILV / gp100 Mouse anti-Human Monoclonal (OTI8A4) Antibody
Dog, Rat, Human, Monkey
IF, WB
Unconjugated
100 µl/$434
PMEL / SILV / gp100 Mouse anti-Human Monoclonal Antibody
Human
IHC, IHC-Fr
Unconjugated
100 µl/$394
PMEL / SILV / gp100 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, WB
Unconjugated
0.1 mg/$379
Yeast
His
49 kD
100 µg/$446; 20 µg/$336; 1 mg/$1,460
PMEL / SILV / gp100 Rabbit anti-Human Polyclonal (aa412-440) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
PMEL / SILV / gp100 Rabbit anti-Human Polyclonal (aa412-440) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
PMEL / SILV / gp100 Rabbit anti-Human Polyclonal (aa412-440) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
PMEL / SILV / gp100 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
PMEL / SILV / gp100 Mouse anti-Pig Monoclonal (Azide-free, BSA-free) (HMB45 + PMEL/783) Antibody
Pig, Human
Flo, IF, IHC, IHC-P
Unconjugated, Azide-free, BSA-free
100 µg/$574
PMEL / SILV / gp100 Rabbit anti-Human Polyclonal (aa25-467) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
50 µg/$294; 100 µg/$360
PMEL / SILV / gp100 Goat anti-Human Polyclonal (aa647-660) Antibody
Human
Peptide-ELISA, WB
Unconjugated
100 µg/$503
PMEL / SILV / gp100 Mouse anti-Human Monoclonal (NKI-beteb) Antibody
Horse, Human
ELISA, Flo, IF, IHC, IHC-P
Unconjugated
20 µg/$371; 100 µg/$574
PMEL / SILV / gp100 Mouse anti-Human Monoclonal (Azide-free, BSA-free) (NKI-beteb) Antibody
Horse, Human
ELISA, Flo, IF, IHC, IHC-P
Unconjugated, Azide-free, BSA-free
100 µg/$574
PMEL / SILV / gp100 Mouse anti-Human Monoclonal (SPM142) Antibody
Human
IHC-P
Unconjugated
20 µg/$371; 100 µg/$574
PMEL / SILV / gp100 Mouse anti-Human Monoclonal (SPM286) Antibody
Horse, Human
Flo, IF, IHC, IHC-P
Unconjugated
20 µg/$371; 100 µg/$574
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