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PLAP / Alkaline Phosphatase

Placental Alkaline Phosphatase

There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2 while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme, also referred to as the heat stable form, that is expressed primarily in the placenta although it is closely related to the intestinal form of the enzyme as well as to the placental-like form. The coding sequence for this form of alkaline phosphatase is unique in that the 3' untranslated region contains multiple copies of an Alu family repeat. In addition, this gene is polymorphic and three common alleles (type 1, type 2 and type 3) for this form of alkaline phosphatase have been well characterized.

Gene Name: Placental Alkaline Phosphatase
Synonyms: ALPP, ALP, Alkaline phosphomonoesterase, Glycerophosphatase, PALP, PLAP, PLAP-1, Alp1, Germ-cell alkaline phosphatase, Nagao isozyme, Regan isozyme
Target Sequences: NM_001632 NP_001623.3 P05187

Publications (4)

1
Fusion of Epstein-Barr virus with epithelial cells can be triggered by v5 in addition to v6 and v8, and integrin binding triggers a conformational change in glycoproteins gHgL. Chesnokova LS, Hutt-Fletcher LM. Journal of virology. 2011 85:13214-23. (Human) [Full Text Article] [PubMed:21957301] [PMC:PMC3233123] Related Antibodies: LS-C44264.
2
Duration of simulated microgravity affects the differentiation of mesenchymal stem cells. Xue L, Li Y, Chen J. Molecular medicine reports. 2017 15:3011-3018. (Flo; Human) [Full Text Article] [PubMed:28339035] [PMC:PMC5428749] Related Antibodies: LS-C44264.
3
alpha v beta 3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1. Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G. Proceedings of the National Academy of Sciences of the United States of America. 2012 Nov;109:19792-7. [Full Text Article] [PubMed:23150579] [PMC:PMC3511702] Related Antibodies: LS-C44264.
4
alpha v beta 6- and alpha v beta 8-integrins serve as interchangeable receptors for HSV gH/gL to promote endocytosis and activation of membrane fusion. Gianni T, Salvioli S, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G. PLoS pathogens. 2013 Dec;9:e1003806. [Full Text Article] [PubMed:24367260] [PMC:PMC3868510] Related Antibodies: LS-C44264.
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ELISA Kits (16)
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PLAP / Alkaline Phosphatase (16)
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PLAP / Alkaline Phosphatase ELISA Kit
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Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$783
PLAP / Alkaline Phosphatase ELISA Kit
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Sandwich
96-Well Strip Plate
Human
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
PLAP / Alkaline Phosphatase ELISA Kit
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Sandwich
96-Well Strip Plate
Human
125 - 8000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$798
PLAP / Alkaline Phosphatase ELISA Kit
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Sandwich
96-Well Strip Plate
Human
3.13 - 200 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$798
PLAP / Alkaline Phosphatase ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$715
PLAP / Alkaline Phosphatase ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Human
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
PLAP / Alkaline Phosphatase ELISA Kit
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Sandwich
96-Well Microplate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
PLAP / Alkaline Phosphatase ELISA Kit
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Competitive EIA
96-Well Strip Plate
Human
0.5 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$805
PLAP / Alkaline Phosphatase ELISA Kit
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Sandwich CLIA
96-Well Strip Plate
Bovine
41.15 - 30000 pg/ml
Chemiluminescent
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$987
PLAP / Alkaline Phosphatase ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
1.25 - 80 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$750
PLAP / Alkaline Phosphatase ELISA Kit
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Sandwich
96-Well Strip Plate
Rabbit
3.13 - 200 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$750
PLAP / Alkaline Phosphatase ELISA Kit
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Sandwich
96-Well Strip Plate
Bovine
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$593
PLAP / Alkaline Phosphatase ELISA Kit
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Sandwich
96-Well Strip Plate
Chicken
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
PLAP / Alkaline Phosphatase ELISA Kit
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Sandwich
96-Well Strip Plate
Porcine
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
PLAP / Alkaline Phosphatase ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
PLAP / Alkaline Phosphatase ELISA Kit
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Sandwich
96-Well Strip Plate
Rabbit
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).