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PFN1 / Profilin 1
profilin 1
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR.
| Gene Name: | profilin 1 |
| Synonyms: | PFN1, ALS18, Profilin-1, Profilin 1, Profilin I |
| Target Sequences: | NM_005022 NP_005013.1 P07737 |
Publications (7)
1
Coordinate induction of the actin cytoskeletal regulatory proteins gelsolin, vasodilator-stimulated phosphoprotein, and profilin during capillary morphogenesis in vitro. Salazar R, Bell SE, Davis GE. Experimental cell research. 1999 249:22-32.
[PubMed:10328950]
2
Megakaryocyte hyperplasia and enhanced agonist-induced platelet activation in vasodilator-stimulated phosphoprotein knockout mice. Hauser W, Knobeloch KP, Eigenthaler M, Gambaryan S, Krenn V, Geiger J, Glazova M, Rohde E, Horak I, Walter U, Zimmer M. Proceedings of the National Academy of Sciences of the United States of America. 1999 96:8120-5.
[PubMed:10393958]
[PMC:PMC22198]
3
A role for polyproline motifs in the spinal muscular atrophy protein SMN. Profilins bind to and colocalize with smn in nuclear gems. Giesemann T, Rathke-Hartlieb S, Rothkegel M, Bartsch JW, Buchmeier S, Jockusch BM, Jockusch H. The Journal of biological chemistry. 1999 274:37908-14.
[PubMed:10608857]
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Sandwich
96-Well Strip Plate
Human
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
Sandwich
96-Well Strip Plate
Rat
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
Sandwich
96-Well Microplate
Human
78.13 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$651
PFN1 / Profilin 1 Rabbit anti-Human Polyclonal (aa1-139) (PE) Antibody
Human
WB
PE Conjugated
100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451
PFN1 / Profilin 1 Mouse anti-Human Monoclonal (OTI2D2) Antibody
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
PFN1 / Profilin 1 Mouse anti-Human Monoclonal (Carrier-free) (OTI2D2) Antibody
Dog, Rat, Human, Monkey
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
PFN1 / Profilin 1 Mouse anti-Human Monoclonal (OTI1D5) Antibody
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
PFN1 / Profilin 1 Mouse anti-Human Monoclonal (Carrier-free) (OTI1D5) Antibody
Dog, Rat, Human, Monkey
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
PFN1 / Profilin 1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
PFN1 / Profilin 1 Rabbit anti-Human Polyclonal (N-Terminus) (HRP) Antibody
Mouse, Guinea pig, Bovine, Rat, Pig, Horse, Gibbon, Human, Monkey
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
PFN1 / Profilin 1 Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody
Mouse, Guinea pig, Bovine, Rat, Pig, Horse, Gibbon, Human, Monkey
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
PFN1 / Profilin 1 Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody
Mouse, Guinea pig, Bovine, Rat, Pig, Horse, Gibbon, Human, Monkey
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
PFN1 / Profilin 1 Rabbit anti-Mercurialis annua Polyclonal Antibody
Mercurialis annua
ELISA
Unconjugated
50 µg/$294; 100 µg/$360
PFN1 / Profilin 1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
PFN1 / Profilin 1 Rabbit anti-Human Polyclonal Antibody
Mouse, Bovine, Rat, Pig, Human
ICC, IHC, WB
Unconjugated
10 µg/$477
PFN1 / Profilin 1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, Flo, WB
Unconjugated
200 µl/$393
PFN1 / Profilin 1 Rabbit anti-Human Polyclonal (Preservative Free) Antibody
Human
ICC, IF, WB
Unconjugated, Preservative Free
100 µl/$412
PFN1 / Profilin 1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$331
PFN1 / Profilin 1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$294; 100 µg/$360
PFN1 / Profilin 1 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
PFN1 / Profilin 1 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
PFN1 / Profilin 1 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
50 µg/$294; 100 µg/$360
PFN1 / Profilin 1 Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat
IHC-P, WB
Unconjugated
100 µl/$412
PFN1 / Profilin 1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
0.1 ml/$386
PFN1 / Profilin 1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µl/$356; 100 µl/$461
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