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PECAM-1 / CD31
platelet/endothelial cell adhesion molecule 1
Induces susceptibility to atherosclerosis (By similarity). Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment). Isoform Delta15 is unable to protect against apoptosis. Modulates BDKRB2 activation. Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in human umbilical cord vein cells (HUVEC).
| Gene Name: | platelet/endothelial cell adhesion molecule 1 |
| Synonyms: | PECAM1, CD31, CD31 antigen, EndoCAM, PECA1, PECAM-1, GPIIA |
| Target Sequences: | NM_000442 NP_000433.4 P16284 |
Publications (40)
1
Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31): alternatively spliced, functionally distinct isoforms expressed during mammalian cardiovascular development. Rosenblum WI, Murata S, Nelson GH, Werner PK, Ranken R, Harmon RC. Development (Cambridge, England). 1994 120:2539-53.
[PubMed:7956830]
2
Anti-CD31 delays platelet adhesion/aggregation at sites of endothelial injury in mouse cerebral arterioles. Rosenblum WI, Murata S, Nelson GH, Werner PK, Ranken R, Harmon RC. The American journal of pathology. 1994 145:33-6.
[PubMed:8030753]
[PMC:PMC1887306]
3
Monoclonal antibodies specific for endothelial cells of mouse blood vessels. Their application in the identification of adult and embryonic endothelium. DeLisser HM, Christofidou-Solomidou M, Strieter RM, Burdick MD, Robinson CS, Wexler RS, Kerr JS, Garlanda C, Merwin JR, Madri JA, Albelda SM. European journal of cell biology. 1994 63:247-54.
[PubMed:8082649]
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Antibodies
(373)
Type
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(373)
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PECAM-1 / CD31
(373)
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Human
(249)
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(126)
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(40)
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(2)
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(3)
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(3)
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(1)
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(3)
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(6)
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(1)
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(5)
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(1)
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(1)
aa690-718
(1)
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(1)
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(1)
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(1)
Publications
No
(364)
Yes
(9)
PECAM-1 / CD31 Mouse anti-Human Monoclonal (1H6) Antibody
Dog, Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
PECAM-1 / CD31 Mouse anti-Human Monoclonal (2F7B2) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
PECAM-1 / CD31 Rabbit anti-Human Polyclonal (aa686-735) Antibody
Mouse, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
Cancer Pathology
Cancer
PECAM-1 / CD31 Mouse anti-Human Monoclonal (1D2-1A5) Antibody
Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
100 µg/$485
PECAM-1 / CD31 Mouse anti-Human Monoclonal (WM59) Antibody
Human, Monkey, Baboon
Flo, IF, IHC, IHC-Fr
Unconjugated
25 µg/$246; 100 µg/$277
PECAM-1 / CD31 Mouse anti-Rat Monoclonal (TLD-3A12) Antibody
Rat, Rhesus monkey
ELISA, Flo, IF, IHC, IHC-Fr, WB
Unconjugated
0.25 mg/$486
PECAM-1 / CD31 Mouse anti-Rat Monoclonal (FITC) (TLD-3A12) Antibody
Rat
Flo, IHC, IHC-Fr
FITC Conjugated
50 µg/$335; 0.1 mg/$444; 0.5 mg/$591
PECAM-1 / CD31 Mouse anti-Human Monoclonal (2F7B2) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
PECAM-1 / CD31 Mouse anti-Human Monoclonal (OTI2C6) Antibody
Human
IHC-P, WB
Unconjugated
50 µl/$460
PECAM-1 / CD31 Rabbit anti-Human Polyclonal (aa231-280) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
PECAM-1 / CD31 Goat anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Dog, Rat, Human, Monkey
IHC-P, WB
Unconjugated
300 µg/$460
PECAM-1 / CD31 Mouse anti-Sheep Monoclonal (FITC) (CO.3E1D4) Antibody
Sheep
Flo
FITC Conjugated
0.1 mg/$540
PECAM-1 / CD31 Mouse anti-Human Monoclonal (OTI2E4) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
PECAM-1 / CD31 Mouse anti-Human Monoclonal (C31.7) Antibody
Human
Flo, IHC-P, WB
Unconjugated
20 µg/$371; 100 µg/$574
PECAM-1 / CD31 Rat anti-Mouse Monoclonal (ER-MP12) Antibody
Mouse
IHC, IHC-Fr, IHC-P
Unconjugated
100 µg/$783
PECAM-1 / CD31 Rat anti-Mouse Monoclonal (Biotin) (ER-MP12) Antibody
Mouse
IHC, IHC-Fr, IHC-P
Biotin Conjugated
300 µg/$830
PECAM-1 / CD31 Mouse anti-Pig Monoclonal (Supernatant) (LCI-9) Antibody
Pig
Flo, IHC-Fr
Unconjugated, Supernatant
2 ml/$509
PECAM-1 / CD31 Mouse anti-Pig Monoclonal (APC) (LCI-4) Antibody
Pig
Flo
APC Conjugated
100 Tests/$580
PECAM-1 / CD31 Rabbit anti-Human Polyclonal (DY550) Antibody
Mouse, Human
Flo, ICC, IF, IHC, IHC-P, WB
DY550 Conjugated
0.1 ml/$416
PECAM-1 / CD31 Mouse anti-Human Monoclonal (C31.3 + C31.7 + C31.10) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
20 µg/$371; 100 µg/$574
PECAM-1 / CD31 Mouse anti-Human Monoclonal (Azide-free, BSA-free) (C31.3 + C31.7 + C31.10) Antibody
Rabbit, Rat, Monkey-Cynomolgus, Human
Flo, IF, IHC, IHC-P, WB
Unconjugated, Azide-free, BSA-free
50 µg/$460
PECAM-1 / CD31 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$294; 100 µg/$360
PECAM-1 / CD31 Rat anti-Mouse Monoclonal (MEC13.3) Antibody
Mouse
Flo, ICC, IHC, IHC-Fr, IHC-P, IP
Unconjugated
0.1 ml/$386
PECAM-1 / CD31 Mouse anti-Rat Monoclonal (Low Endotoxin) (TLD-3A12) Antibody
Rat
ELISA, Flo, IF, IHC, IHC-Fr, WB
Unconjugated, Low Endotoxin
0.5 mg/$712
PECAM-1 / CD31 Mouse anti-Human Monoclonal (Carrier-free) (1H6) Antibody
Dog, Human
Flo, IF, WB
Unconjugated, Carrier-free
100 µg/$511
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