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PDGF-BB

platelet-derived growth factor beta polypeptide

PDGF-BB is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

Gene Name: platelet-derived growth factor beta polypeptide
Family/Subfamily: PDGF , not assigned-PDGF
Synonyms: PDGFB, PDGF-BB, PDGF-b, SSV, PDGF subunit B, PDGF-2, PDGF2, Proto-oncogene c-Sis, SIS, C-sis, PDGF, B chain
Target Sequences: NM_002608 NP_002599.1 P01127

Publications (5)

1
Effects of Increased Renal Tubular Vascular Endothelial Growth Factor (VEGF) on Fibrosis, Cyst Formation, and Glomerular Disease. Samy Hakroush, Marcus J. Moeller, Franziska Theilig, Brigitte Kaissling, Tjeerd P. Sijmonsma, Manfred Jugold, Ann L. Akeson, Milena Traykova-Brauch, Hiltraud Hosser, Brunhilde Hähnel, Hermann-Josef Gröne, Robert Koesters, and Wilhelm Kriz. The American journal of pathology. 2009 275:1883-95. (IHC-P; Mouse) [Full Text Article] [PubMed:19834063] [PMC:PMC2774053]
2
Severe renal mass reduction impairs recovery and promotes fibrosis after AKI. Polichnowski AJ, Lan R, Geng H, Griffin KA, Venkatachalam MA, Bidani AK. Journal of the American Society of Nephrology : JASN. 2014 25:1496-507. (WB; Human) [Full Text Article] [PubMed:24511135] [PMC:PMC4073422]
3
Creation of disease-inspired biomaterial environments to mimic pathological events in early calcific aortic valve disease. Ana M Porras, Jennifer A Westlund, Austin D Evans, Kristyn S Masters. Proceedings of the National Academy of Sciences of the United States of America. 2018 January;115:E363-E371. [Full Text Article] [PubMed:29282325] [PMC:PMC5776956] Related Antibodies: LS-B4182.
4
Angiogenic responses in a 3D micro-engineered environment of primary endothelial cells and pericytes. Jing Bai , Mehrdad Khajavi, Lufei Sui, Haojie Fu, Subrahmanian Tarakkad Krishnaji, Amy E Birsner, Lauren Bazinet, Roger D Kamm, Robert J D'Amato. Angiogenesis. 2021 Feb;;24:111-127. [Full Text Article] [PubMed:32955682] Related Antibodies: LS-C201038.
5
Lysophosphatidic acid increases proximal tubule cell secretion of profibrotic cytokines PDGF-B and CTGF through LPA2- and G alpha q-mediated Rho and alpha v beta 6 integrin-dependent activation of TGF- beta . Geng H, Lan R, Singha PK, Gilchrist A, Weinreb PH, Violette SM, Weinberg JM, Saikumar P, Venkatachalam MA. The American journal of pathology. 2012 Oct;181:1236-49. [Full Text Article] [PubMed:22885106] [PMC:PMC3463629] Related Antibodies: LS-B4182.
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ELISA Kits (60)
Cell-Based (1)
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PDGF-BB (60)
Human (17)
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Pig (5)
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1000 Wells (1)
12 x 8-Well Microstrips (6)
96-Well Microplate (14)
96-Well Strip Plate (36)
No (60)
Adherent Cell Cultures (1)
Ascites (1)
Cell Culture Supernatants (14)
Cell Lysates (6)
EDTA Plasma (3)
Heparin Plasma (3)
Plasma (50)
Platelet-Poor Plasma (1)
Serum (51)
Tissue Homogenates (19)
PDGF-BB ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$863
PDGF-BB ELISA Kit
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Sandwich
96-Well Strip Plate
Cow
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$851
PDGF-BB ELISA Kit
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Sandwich
96-Well Strip Plate
Human
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$585
PDGF-BB ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$585
PDGF-BB ELISA Kit
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Sandwich
96-Well Microplate
Rabbit
6 - 1500 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$534
PDGF-BB ELISA Kit
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Sandwich
96-Well Strip Plate
Porcine
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Ascites, Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$656
PDGF-BB ELISA Kit
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Sandwich
Human
31.2 - 2000 pg/ml
Cell Culture Supernatants, Cell Lysates, EDTA Plasma, Heparin Plasma, Serum
1 Plate/$699
PDGF-BB ELISA Kit
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Cell-Based
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$534
PDGF-BB ELISA Kit
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Sandwich
96-Well Microplate
Pig
10.24 - 2500 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$534
PDGF-BB ELISA Kit
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Sandwich
96-Well Strip Plate
Human
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$730
PDGF-BB ELISA Kit
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Sandwich
96-Well Strip Plate
Pig
46.88 - 3000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$851
PDGF-BB ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$585
PDGF-BB ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Platelet-Poor Plasma, Serum
1 Plate/$906
PDGF-BB ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
39.063 - 2500 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$822
PDGF-BB ELISA Kit
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Sandwich
Mouse
62.5 - 4000 pg/ml
Cell Culture Supernatants, EDTA Plasma, Heparin Plasma, Serum
1 Plate/$699
PDGF-BB ELISA Kit
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Sandwich
Human
31.2 - 2000 pg/ml
Cell Culture Supernatants, EDTA Plasma, Heparin Plasma, Serum
1 Plate/$699
PDGF-BB ELISA Kit
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Sandwich
96-Well Microplate
Equine
8.19 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$610
PDGF-BB ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Rat
12.5 - 800 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
PDGF-BB ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
23.438 - 1500 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
PDGF-BB ELISA Kit
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Sandwich
96-Well Strip Plate
Chicken
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
PDGF-BB ELISA Kit
Select
Sandwich
96-Well Strip Plate
Guinea pig
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
PDGF-BB ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
93.75 - 6000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$897
PDGF-BB ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$968
PDGF-BB ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.18 - 12 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$822
PDGF-BB ELISA Kit
Select
Sandwich
96-Well Microplate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$581
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).