PDCD4

programmed cell death 4 (neoplastic transformation inhibitor)

This gene encodes a protein localized to the nucleus in proliferating cells. Expression of this gene is modulated by cytokines in natural killer and T cells. The gene product is thought to play a role in apoptosis but the specific role has not yet been determined. Two transcripts encoding different isoforms have been identified. PDCD4 inhibits the translation initiation factor E1F4A. Phosphorylation by AKT causes nuclear translocation of PDCD4 and also decreases the ability of PDCD4 to interfere with the transactivation of AP-1 responsive promoter by c-JUN. Loss of PDCD4 expression in human lung carcinoma correlates with tumor progression and prognosis.

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Products

Antibodies (67)

ELISA Kits (9)

Proteins (5)

Type

Cell-Based (1)

Cell-Based Phosphorylation (2)

Custom (2)

Primary (67)

Recombinant (5)

Sandwich (4)

Target

PDCD4 (81)

Reactivity

Human (73)

Mouse (51)

Rat (48)

Bat (8)

Bovine (10)

Chicken (5)

Dog (10)

Gibbon (6)

Goat (9)

Guinea pig (8)

Hamster (9)

Horse (9)

Monkey (11)

Orangutan (6)

Pig (7)

Rabbit (9)

Xenopus (9)

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Application

IHC (42)

IHC-P (15)

WB (61)

Flo (2)

ELISA (30)

ICC (3)

IF (9)

IP (6)

Peptide-ELISA (9)

Host

rabbit (58)

mouse (7)

goat (2)

Product Group

IHCPlus (3)

PathPlus Cancer (4)

Isotype

IgG (47)

IgG1 (1)

IgG1,k (6)

Clonality

monoclonal mc (7)

polyclonal pc (60)

Clone

9G6 (4)

K4C1 (1)

Format

96-Well Microplate (3)

96-Well Strip Plate (6)

APC Conjugated (1)

Azide-free (1)

Biotin Conjugated (4)

FITC Conjugated (3)

HRP Conjugated (3)

PE Conjugated (1)

Unconjugated (55)

Epitope

pSer457 (10)

N-Terminus (9)

aa121-149 (7)

pSer67 (4)

400-480 aa (2)

aa1-260 (2)

aa1-469 (2)

10-90 aa (1)

Ab-67 (1)

C-Terminus (1)

Lys453 (1)

aa100-150 (1)

aa210-221 (1)

aa269-281 (1)

aa33-82 (1)

aa419-469 (1)

aa420-469 (1)

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Publications

No (75)

Yes (6)

Sample Type

Adherent Cell Cultures (3)

Cell Lysates (1)

Plasma (3)

Serum (3)

Tissue Homogenates (2)

Tag

6His, C-terminus (2)

GST (1)

His, N-terminus + His, C-terminus (1)

Species

Human (5)

Source

E. coli (4)

Wheat Germ Extract (1)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (2)

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IHC-plus™ PDCD4 Antibody (aa210-221) LS-B9458

(5.0) Rating

(1) Publication(s)

Antibody:

PDCD4 Goat anti-Human Polyclonal (aa210-221) Antibody

Reactivity:

Xenopus, Chicken, Bovine, Rabbit, Mouse, Goat, Dog, Guinea pig, Bat, Rat, Hamster, Horse, Human, Monkey

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µg/$485

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IHC-plus™ PDCD4 Antibody (phospho-Ser457) LS-B487

(5.0) Rating

(1) Publication(s)

Antibody:

PDCD4 Rabbit anti-Human Polyclonal (pSer457) Antibody

Reactivity:

Xenopus, Rat, Mouse, Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$515

Select

PathPlus™ PDCD4 Antibody (aa1-469, clone K4C1) LS-B2949

Cancer

(5.0) Rating

Antibody:

PDCD4 Mouse anti-Human Monoclonal (aa1-469) (K4C1) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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PathPlus™ PDCD4 Antibody LS-B1388

Cancer

(5.0) Rating

(3) Publication(s)

Antibody:

PDCD4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$440

Select

IHC-plus™ PDCD4 Antibody LS-B65

(5.0) Rating

(1) Publication(s)

Antibody:

PDCD4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Xenopus, Rat, Mouse, Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$515

Select

Mouse PDCD4 (Sandwich ELISA) ELISA Kit - LS-F19748

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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PDCD4 Antibody (phospho-Ser457, clone 9G6) LS-C154004

(4.0) Rating

(1) Publication(s)

Antibody:

PDCD4 Mouse anti-Human Monoclonal (pSer457) (9G6) Antibody

Reactivity:

Xenopus, Rat, Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$574

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PDCD4 Antibody (phospho-Ser457, clone 9G6, Biotin) LS-C153791

(4.0) Rating

(1) Publication(s)

Antibody:

PDCD4 Mouse anti-Human Monoclonal (pSer457) (Biotin) (9G6) Antibody

Reactivity:

Xenopus, Rat, Mouse, Human

Applications:

ELISA, IP, WB

Format:

Biotin Conjugated

Price:

50 µg/$472

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PDCD4 Antibody LS-C179904

Antibody:

PDCD4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Dog, Human

Applications:

ICC, IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

100 µl/$403

Select

PDCD4 Antibody (phospho-Ser67) LS-C416836

Antibody:

PDCD4 Rabbit anti-Human Polyclonal (pSer67) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

50 µg/$305; 100 µg/$357

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PDCD4 Antibody (phospho-Ser457) LS-C801213

Antibody:

PDCD4 Rabbit anti-Human Polyclonal (pSer457) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

PathPlus™ PDCD4 Antibody (aa33-82) LS-B12425

Cancer

(5.0) Rating

Antibody:

PDCD4 Rabbit anti-Human Polyclonal (aa33-82) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, Peptide-ELISA

Format:

Unconjugated

Price:

100 µl/$515

Select

PDCD4 Antibody (400-480 aa) LS-C385400

Antibody:

PDCD4 Rabbit anti-Human Polyclonal (400-480 aa) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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PathPlus™ PDCD4 Antibody LS-B6949

Cancer

(5.0) Rating

Antibody:

PDCD4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Chicken, Bovine, Rabbit, Mouse, Goat, Dog, Rat, Hamster, Pig, Horse, Bat, Human, Monkey

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$440

Select

PDCD4 Antibody LS-C667538

Antibody:

PDCD4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, IP, WB

Format:

Unconjugated

Price:

100 µg/$331

Select

PDCD4 Antibody (aa1-260) LS-C377709

Antibody:

PDCD4 Rabbit anti-Human Polyclonal (aa1-260) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$294; 100 µl/$360

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PDCD4 Antibody (Lys453) LS-C176644

Antibody:

PDCD4 Rabbit anti-Human Polyclonal (Lys453) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

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PDCD4 Antibody LS-C801394

Antibody:

PDCD4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

PDCD4 Antibody LS-C332086

Antibody:

PDCD4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Flo, IHC, IP, WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$409

Select

PDCD4 Antibody (phospho-Ser457, clone 9G6) LS-C744821

Antibody:

PDCD4 Mouse anti-Human Monoclonal (pSer457) (9G6) Antibody

Reactivity:

Xenopus, Rat, Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

25 µl/$304

Select

PDCD4 Antibody LS-C745303

Antibody:

PDCD4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Xenopus, Rat, Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

25 µl/$304

Select

PDCD4 Antibody LS-C417657

Antibody:

PDCD4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IF, WB

Format:

Unconjugated

Price:

50 µg/$305; 100 µg/$357

Select

PDCD4 Antibody (phospho-Ser457) LS-C199415

Antibody:

PDCD4 Rabbit anti-Human Polyclonal (pSer457) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

PDCD4 Antibody LS-C667536

Antibody:

PDCD4 Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$361

Select

PDCD4 Antibody (phospho-Ser457, clone 9G6) LS-C744829

Antibody:

PDCD4 Mouse anti-Human Monoclonal (pSer457) (9G6) Antibody

Reactivity:

Xenopus, Rat, Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

1 mg/$2,600

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