PDCD4 is a protein that localizes to the nucleus in proliferating cells. PDCD4 expression is modulated by cytokines in natural killer and T cells, and it is thought to play a role in apoptosis. PDCD4 inhibits the translation initiation factor E1F4A, and phosphorylation by AKT causes nuclear translocation of PDCD4 and also decreases the ability of PDCD4 to interfere with the transactivation of AP-1 responsive promoter by c-JUN. Loss of PDCD4 expression in human lung carcinoma correlates with tumor progression and prognosis. In immunohistochemistry, PDCD4 has nuclear and cytoplasmic positivity in a majority of tissues throughout the body. References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804;