PARP1

poly (ADP-ribose) polymerase 1

Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Required for PARP9 and DTX3L recruitment to DNA damage sites. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites.

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Products

Proteins (13)

Type

Over-Expression Lysate (2)

Recombinant (11)

Target

PARP1 (13)

Publications

No (13)

Tag

DDK,C-terminus (1)

GST, N-terminus (1)

His (3)

His-HA (1)

His-Myc (1)

His-T7 (2)

Myc-DDK (Flag) (3)

Species

Human (9)

Mouse (3)

Source

293T Cells (1)

Baculovirus (2)

E. coli (4)

HEK 293 Cells (2)

Sf21 Cells (2)

Sf9 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (3)

Biologically Active

Biologically active (1)

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Human PARP1 Protein (Recombinant His-Myc) (Full Length) - LS-G3996

Source:

Sf21 Cells

Tag:

His-Myc

Biological Activity:

Biologically active

Price:

10 µg/$393

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Human PARP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78131

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

112.9 kDa

Price:

20 µg/$150

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Human PARP1 Protein (Recombinant His) (Met1-Trp1014) - LS-G97746

Source:

Baculovirus

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

114.5 kDa

Price:

50 µg/$710

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Human PARP1 Protein (Recombinant His-HA) (Full Length) - LS-G4000

Source:

Sf21 Cells

Tag:

His-HA

Price:

10 µg/$309

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Human PARP1 Protein (Recombinant GST, N-terminus) (aa1-100) - LS-G57717

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human PARP1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66623

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

112.9 kDa

Price:

20 µg/$1,107

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Mouse PARP1 Protein (Recombinant His-T7) (aa661-881) - LS-G11937

Source:

E. coli

Tag:

His-T7

Molecular Weight:

29.0 kDa

Price:

10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284

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Mouse PARP1 Protein (Recombinant His-T7) (aa788-1014) - LS-G23967

Source:

E. coli

Tag:

His-T7

Molecular Weight:

29.1 kDa

Price:

10 µg/$291; 50 µg/$502; 100 µg/$802; 200 µg/$1,002; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334

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Mouse PARP1 Protein (Recombinant His) (Met1-Trp1014) - LS-G98229

Source:

Baculovirus

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

115 kDa

Price:

100 µg/$843

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PARP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99493

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

112.9 kDa

Price:

100 µg/$494

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Human PARP1 Protein (Recombinant DDK,C-terminus) - LS-G142355

Source:

Sf9 Cells

Tag:

DDK,C-terminus

Molecular Weight:

113 kDa

Price:

20 µg/$677

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Human PARP1 Protein (Recombinant) - LS-G704

Source:

E. coli

Tag:

None

Price:

100 µg/$342; 500 µg/$641; 20 µg/$254

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Human PARP1 Protein (Recombinant His) (aa81-230) - LS-G141115

Source:

E. coli

Sequence Length:

149 AA

Tag:

His

Endotoxin Level:

Less than 0.1 EU/µg protein (determined by LAL method).

Molecular Weight:

16.5 kDa

Price:

10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531

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