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PARP1
poly (ADP-ribose) polymerase 1
Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Required for PARP9 and DTX3L recruitment to DNA damage sites. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites.
| Gene Name: | poly (ADP-ribose) polymerase 1 |
| Synonyms: | PARP1, ADPRT, ADP-ribosyltransferase NAD(+), Adp-ribosyltransferase, ADPRT1, ARTD1, ADPRT 1, Poly(ADP-ribose) synthetase, Poly(ADP-ribosyl)transferase, PARP, Poly [ADP-ribose] polymerase 1, PADPRT-1, PARP-1, Poly (ADP-ribose) polymerase 1, Poly(ADP-ribose) polymerase, Poly[ADP-ribose] synthase 1, PPOL |
| Target Sequences: | NM_001618 NP_001609.2 P09874 |
Publications (6)
1
An Ang1-Tie2-PI3K axis in neural progenitor cells initiates survival responses against oxygen and glucose deprivation. Bai Y, Meng Z, Cui M, Zhang X, Chen F, Xiao J, Shen L, Zhang Y. Neuroscience. 2009 160:371-81. (WB)
[PubMed:19409199]
2
Superoxide anion and proteasomal dysfunction contribute to curcumin-induced paraptosis of malignant breast cancer cells. Yoon MJ, Kim EH, Lim JH, Kwon TK, Choi KS. Free radical biology & medicine. 2010 48:713-26. (WB)
[PubMed:20036734]
3
Novel Trajectories of Bromocriptine Antidiabetic Action: Leptin-IL-6/ JAK2/p-STAT3/SOCS3, p-IR/p-AKT/GLUT4, PPAR-?/Adiponectin, Nrf2/PARP-1, and GLP-1. Reda E, Hassaneen S, El-Abhar HS. Frontiers in pharmacology. 2018 July;9:771. [Full Text Article]
[PubMed:30072896]
[PMC:PMC6058031]
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(185)
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(1)
PARP1 Mouse anti-Human Monoclonal (A6.4.12) Antibody
Human
ELISA, IF, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
0.05 mg/$460
PARP1 Rabbit anti-Human Monoclonal (Gly623) (46D11) Antibody
Mouse, Rat, Human, Monkey
ELISA, IF, IHC, IHC-P, IP, WB
Unconjugated
50 µl/$565
PARP1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
250 µl/$485
PARP1 Rabbit anti-Human Polyclonal (aa1-1014) Antibody
Xenopus, Chicken, Bovine, Mouse, Human
ELISA, ICC, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
50 µl/$485
PARP1 Mouse anti-Human Monoclonal (194C1439) Antibody
Human
Flo, WB
Unconjugated
0.1 mg/$386
PARP1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IE, IHC, WB
Unconjugated
100 µg/$567
PARP1 Mouse anti-Mouse Monoclonal (N-Terminus) (5A5) Antibody
Mouse, Human
ICC, IF, WB
Unconjugated
25 µg/$276; 100 µg/$354
PARP1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, Flo, ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$717
PARP1 Mouse anti-Human Monoclonal (5F1) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
PARP1 Mouse anti-Human Monoclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$321
PARP1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Bovine, Human
IHC, WB
Unconjugated
100 µl/$842
PARP1 Rabbit anti-Human Polyclonal (aa123-151) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
PARP1 Rabbit anti-Human Polyclonal (aa183-214) Antibody
Human
Flo, ICC, IF, WB
Unconjugated
400 µl/$393
PARP1 Rabbit anti-Human Polyclonal (aa670-858) Antibody
Mouse, Rat, Human
ICC, IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
PARP1 Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF, IHC, IHC-P, IP, WB
Unconjugated
100 µl/$412
PARP1 Mouse anti-Human Monoclonal (Carrier-free) (5F1) Antibody
Human
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
PARP1 Rabbit anti-Human Monoclonal Antibody
Mouse, Rat, Human, Monkey
IP
Unconjugated
400 µl/$694
PARP1 Rabbit anti-Human Polyclonal Antibody
Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
PARP1 Rabbit anti-Human Polyclonal (aa215-525) Antibody
Mouse, Human, Monkey
ICC, IHC, IP, WB
Unconjugated
100 µl/$587
PARP1 Mouse anti-Human Monoclonal Antibody
Xenopus, Drosophila, Mouse, Rat, Hamster, Human
ELISA, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
100 µg/$686
PARP1 Mouse anti-Human Monoclonal (HRP) Antibody
Xenopus, Drosophila, Mouse, Rat, Hamster, Human
ELISA, IHC, IP, WB
HRP Conjugated
100 µl/$872
PARP1 Mouse anti-Human Monoclonal (FITC) Antibody
Xenopus, Drosophila, Mouse, Rat, Hamster, Human
ELISA, IHC, IP, WB
FITC Conjugated
100 µl/$872
PARP1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
![PARP1 Antibody - Immunofluorescence of monoclonal antibody to PARP1 on HeLa cell. [antibody concentration 10 ug/ml]](https://lsbio-7d62.kxcdn.com/image2/parp1-antibody-clone-3g4-ls-c196622/143803_4951547.jpg)
PARP1 Mouse anti-Human Monoclonal (3G4) Antibody
Human
ELISA, IF, WB
Unconjugated
100 µg/$423
PARP1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IE, IHC, WB
Unconjugated
25 µl/$304
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