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PARK2 / Parkin 2

parkin RBR E3 ubiquitin protein ligase

Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins, such as BCL2, SYT11, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, a 22 kDa O-linked glycosylated isoform of SNCAIP, SEPT5, TOMM20, USP30, ZNF746 and AIMP2. Mediates monoubiquitination as well as 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context. Participates in the removal and/or detoxification of abnormally folded or damaged protein by mediating 'Lys-63'-linked polyubiquitination of misfolded proteins such as PARK7: 'Lys-63'-linked polyubiquitinated misfolded proteins are then recognized by HDAC6, leading to their recruitment to aggresomes, followed by degradation. Mediates 'Lys-63'-linked polyubiquitination of SNCAIP, possibly playing a role in Lewy-body formation. Mediates monoubiquitination of BCL2, thereby acting as a positive regulator of autophagy. Promotes the autophagic degradation of dysfunctional depolarized mitochondria (mitophagy) by promoting the ubiquitination of mitochondrial proteins such as TOMM20, RHOT1/MIRO1 and USP30 (PubMed:24896179). Mediates 'Lys-48'-linked polyubiquitination of ZNF746, followed by degradation of ZNF746 by the proteasome; possibly playing a role in the regulation of neuron death. Limits the production of reactive oxygen species (ROS). Regulates cyclin-E during neuronal apoptosis. In collaboration with CHPF isoform 2, may enhance cell viability and protect cells from oxidative stress. Independently of its ubiquitin ligase activity, protects from apoptosis by the transcriptional repression of p53/TP53. May protect neurons against alpha synuclein toxicity, proteasomal dysfunction, GPR37 accumulation, and kainate-induced excitotoxicity. May play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. May represent a tumor suppressor gene.

Gene Name: parkin RBR E3 ubiquitin protein ligase
Synonyms: PARK2, AR-JP, LPRS2, Parkin, PDJ, Parkinson disease protein 2, PRKN, PRKN2
Target Sequences: NM_004562 NP_004553.2 O60260

Publications (1)

1
Overexpression of parkin ameliorates dopaminergic neurodegeneration induced by 1- methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice. Bian M, Liu J, Hong X, Yu M, Huang Y, Sheng Z, Fei J, Huang F. PloS one. 2012 7:e39953. [PubMed:22792139] [PMC:PMC3390003] Related Antibodies: LS-C99184.

☰ Filters
Antibodies (49)
Proteins (11)
ELISA Kits (3)
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Over-Expression Lysate (5)
Primary (49)
Recombinant (6)
Sandwich (2)
PARK2 / Parkin 2 (63)
Human (51)
Mouse (23)
Rat (21)
Bovine (4)
Monkey (3)
Orangutan (3)
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IHC (29)
IHC-P (14)
WB (42)
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ELISA (17)
ICC (3)
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Peptide-ELISA (5)
rabbit (46)
mouse (3)
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monoclonal mc (3)
polyclonal pc (46)
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aa229-465 (7)
aa1-465 (4)
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70-150 aa (2)
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pSer131 (2)
1-80 aa, N-terminal (1)
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aa1-437 (1)
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No (62)
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Human (9)
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Purified (3)
PARK2 / Parkin 2 Antibody - Parkin Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human brain tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
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PARK2 / Parkin 2 Rabbit anti-Human Polyclonal (aa111-140) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
PARK2 / Parkin 2 Antibody - Anti-PARK2 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PARK2 / Parkin 2 Rabbit anti-Mouse Polyclonal (aa311-360) Antibody
Mouse
IHC, IHC-P, WB
Unconjugated
100 µl/$485
PARK2 / Parkin 2 Antibody - Anti-PARK2 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PARK2 / Parkin 2 Rabbit anti-Mouse Polyclonal (aa311-360) (FITC) Antibody
Mouse, Rat, Orangutan, Human
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
PARK2 / Parkin 2 Antibody - Immunofluorescence of monoclonal antibody to PARK2 on HeLa cell. [antibody concentration 10 ug/ml]
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PARK2 / Parkin 2 Mouse anti-Human Monoclonal (1H4) Antibody
Rat, Human
ELISA, IF, WB
Unconjugated
100 µg/$423
PARK2 / Parkin 2 Antibody - Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Neuroscience
PARK2 / Parkin 2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$440
PARK2 / Parkin 2 Antibody - Immunohistochemical analysis of Parkin staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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PARK2 / Parkin 2 Rabbit anti-Human Polyclonal (Internal) Antibody
Bovine, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
30 µl/$255; 100 µl/$299; 200 µl/$351
PARK2 / Parkin 2 Antibody - Immunohistochemistry of PARK2 in human brain tissue with PARK2 antibody at 5 ug/ml.
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PARK2 / Parkin 2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
0.1 mg/$460
PARK2 / Parkin 2 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$792
PARK2 / Parkin 2 Antibody - Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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PARK2 / Parkin 2 Rabbit anti-Human Polyclonal (aa387-417) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
PARK2 / Parkin 2 Antibody - Parkin antibody IHC-paraffin: Mouse Brain Tissue.
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PARK2 / Parkin 2 Rabbit anti-Human Polyclonal (aa23-416) Antibody
Mouse, Rat, Human
ICC, IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
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PARK2 / Parkin 2 Rabbit anti-Human Polyclonal (aa1-465) (HRP) Antibody
Human
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
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PARK2 / Parkin 2 Rabbit anti-Human Polyclonal (aa1-465) (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
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PARK2 / Parkin 2 Rabbit anti-Human Polyclonal (1-80 aa, N-terminal) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
PARK2 / Parkin 2 Antibody - Anti-PARK2 antibody IHC of human thyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
Select
Neuroscience
PARK2 / Parkin 2 Rabbit anti-Human Polyclonal (aa1-50) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$440
PARK2 / Parkin 2 Antibody - Immunofluorescent analysis of Parkin staining in HepG2 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).
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PARK2 / Parkin 2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Bovine, Rat, Pig, Human, Monkey
ICC, IF, WB
Unconjugated
100 µl/$299
PARK2 / Parkin 2 Antibody - P-peptide - + Immunohistochemistry analysis of paraffin-embedded human skeletal muscle tissue using Parkin (Phospho-Ser131) antibody.
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PARK2 / Parkin 2 Rabbit anti-Human Polyclonal (pSer131) Antibody
Mouse, Human
ELISA, IHC
Unconjugated
100 µg/$357
PARK2 / Parkin 2 Antibody - Western blot of HeLa cell lysate using Parkin Antibody
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PARK2 / Parkin 2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µg/$305; 100 µg/$357
PARK2 / Parkin 2 Antibody - Western blot of PARK2 / Parkin 2 antibody.
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PARK2 / Parkin 2 Rabbit anti-Human Polyclonal (aa229-465) (PE) Antibody
Pig, Human
WB
PE Conjugated
100 µl/$427; 200 µl/$519; 500 µl/$916; 1 ml/$1,084
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PARK2 / Parkin 2 Mouse anti-Human Monoclonal (C-Terminus) (PRK109) Antibody
Mouse, Rat, Human
ELISA, IF, IP, WB
Unconjugated
1 ml/$786
PARK2 / Parkin 2 Antibody - IHC of Parkin (G12) pAb in paraffin-embedded human brain tissue.
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PARK2 / Parkin 2 Rabbit anti-Human Polyclonal (Gly12) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
PARK2 / Parkin 2 Protein
Select
E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
PARK2 / Parkin 2 Antibody - Immunohistochemistry analysis of paraffin-embedded human brain tissue, using Parkin Antibody. The picture on the right is blocked with the synthesized peptide.
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PARK2 / Parkin 2 Rabbit anti-Human Polyclonal (aa101-150) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
Select
PARK2 / Parkin 2 Rabbit anti-Human Polyclonal (aa300-350) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
40 µg/$485
PARK2 / Parkin 2 Antibody - Western blot of Phospho-Parkin (S131) antibody
Select
PARK2 / Parkin 2 Rabbit anti-Human Polyclonal (70-150 aa) Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
PARK2 / Parkin 2 Antibody - Western blot of Parkin antibody
Select
PARK2 / Parkin 2 Rabbit anti-Human Polyclonal (70-150 aa) Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
Viewing 1-25 of 63 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).