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Osteonectin / SPARC
secreted protein, acidic, cysteine-rich (osteonectin)
SPARC (secreted protein acidic and rich in cysteine)/Osteonectin is a matricellular glycoprotein that modulates cellular interactions with the ECM and is expressed in tissues undergoing remodeling. It functions as a de-adhesive protein, as a modulator of growth factor activity, and as a cell-cycle inhibitor. It induces changes in endothelial cell shape via F-actin, coincident with the appearance of intercellular gaps, that provide a paracellular pathway for extravasation of macromolecules. Tumor growth is enhanced in mice lacking SPARC due to changes in the ECM that create a more permissive environment for tumor progression.
| Gene Name: | secreted protein, acidic, cysteine-rich (osteonectin) |
| Synonyms: | SPARC, Basement-membrane protein 40, BM-40, Cysteine-rich protein, ON, Osteonectin |
| Target Sequences: | NM_003118 NP_003109.1 P09486 |
Publications (3)
1
Collagen-Hydroxyapatite Scaffolds Induce Human Adipose Derived Stem Cells Osteogenic Differentiation In Vitro. Calabrese G, Giuffrida R, Fabbi C, Figallo E, Lo Furno D, Gulino R, Colarossi C, Fullone F, Giuffrida R, Parenti R, Memeo L, Forte S. PloS one. 2016 11:e0151181. (WB, ELISA, IHC-Fr; Bovine, Human)
[Full Text Article]
[PubMed:26982592]
[PMC:PMC4794180]
2
Overexpression of SPARC correlates with poor prognosis in patients with cervical carcinoma and regulates cancer cell epithelial-mesenchymal transition. Shi D, Jiang K, Fu Y, Fang R, Liu XI, Chen J. Oncology letters. 2016 May;11:3251-3258. [Full Text Article]
[PubMed:27123099]
[PMC:PMC4841103]
3
Calcitonin gene-related peptide stimulates proliferation and osteogenic differentiation of osteoporotic rat-derived bone mesenchymal stem cells. Liang W, Zhuo X, Tang Z, Wei X, Li B. Molecular and cellular biochemistry. Apr;402:101-10. [Full Text Article]
[PubMed:25563479]
Related Antibodies: LS-C25800.
☰ Filters
Products
Proteins
(20)
Type
Over-Expression Cell Culture Supernatant
(1)
Over-Expression Lysate
(3)
Recombinant
(16)
Target
Osteonectin / SPARC
(20)
Publications
No
(20)
Tag
6His, C-terminus
(3)
6His, N-terminus
(1)
8His, N-terminus
(1)
GST
(2)
His
(3)
His, N-Terminal
(1)
His,C-terminus
(1)
His-T7
(2)
Myc-DDK (Flag)
(3)
Species
Human
(14)
Mouse
(3)
Rabbit
(1)
Rat
(1)
Source
293T Cells
(1)
CHO Cells
(1)
E. coli
(8)
HEK 293 Cells
(5)
Human
(1)
Human Cells
(1)
Mammalian Cells
(2)
Wheat Germ Extract
(1)
Purification
Purified
(7)
Low Endotoxin Level
Low endotoxin level
(6)
Biologically Active
Biologically active
(4)
E. coli
His
33.6 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
CHO Cells
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
43.7 kDa
10 µg/$268; 50 µg/$349
E. coli
His-T7
32.8 kDa
10 µg/$286; 50 µg/$472; 100 µg/$752; 200 µg/$942; 1 mg/$2,069; 500 µg/$1,600; 5 mg/$3,291; 2 mg/$2,257
E. coli
None
Biologically active
32.7 kDa
10 µg/$282; 500 µg/$1,058; 100 µg/$503
E. coli
His
Biologically active
36.1 kDa
10 µg/$282; 100 µg/$503; 500 µg/$1,058
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
33.73kD
10 µg/$248; 50 µg/$313; 500 µg/$743; 1 mg/$1,048
Wheat Germ Extract
GST
59.07 kDa
10 µg/$479; 25 µg/$670
293T Cells
Myc-DDK (Flag)
34.5 kDa
20 µg/$150
Human
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
33.6kD
50 µg/$395; 500 µg/$1,262; 1 mg/$1,627; 10 µg/$277
HEK 293 Cells
His, N-Terminal
35 kDa (40-45 kDa reducing conditions)
10 µg/$289; 50 µg/$360
HEK 293 Cells
Myc-DDK (Flag)
34.5 kDa
20 µg/$1,107
HEK 293 Cells
Myc-DDK (Flag)
34.5 kDa
100 µg/$494
E. coli
None
Biologically active
Less than 1 EU/µg (determined by LAL method).
36.1 kDa
1 mg/$1,656; 50 µg/$364
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
33.7 kDa
10 µg/$248; 50 µg/$311
Mammalian Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
33.6 kDa
10 µg/$277; 50 µg/$389
E. coli
GST
60.1 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
HEK 293 Cells
8His, N-terminus
35 kDa
100 µg/$298
HEK 293 Cells
6His, N-terminus
35 kDa
200 µl/$283
E. coli
His
33.8 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
E. coli
His-T7
36.2 kDa
10 µg/$260; 50 µg/$335; 100 µg/$497; 200 µg/$622; 1 mg/$1,588; 500 µg/$1,185; 5 mg/$2,522; 2 mg/$1,760
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