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Osteocalcin

bone gamma-carboxyglutamate (gla) protein

Osteocalcin (BGLAP) is secreted by osteoblasts and plays a role in metabolic regulation. It is pro-osteoblastic (bone-building). It is also implicated in bone mineralization and calcium ion homeostasis. Osteocalcin acts as a hormone in the body, causing beta cells in the pancreas to release more insulin, and at the same time directing fat cells to release the hormone adiponectin, which increases sensitivity to insulin. It may play a role in male fertility, enhancing the synthesis of testosterone.

Gene Name:	bone gamma-carboxyglutamate (gla) protein
Synonyms:	BGLAP, Bone Gla protein, BGP, OC, Osteocalcin
Target Sequences:	BG752923 NP_954642.1 P02818

Publications (11)

Collagen-Hydroxyapatite Scaffolds Induce Human Adipose Derived Stem Cells Osteogenic Differentiation In Vitro. Calabrese G, Giuffrida R, Fabbi C, Figallo E, Lo Furno D, Gulino R, Colarossi C, Fullone F, Giuffrida R, Parenti R, Memeo L, Forte S. PloS one. 2016 11:e0151181. (WB, ELISA, IHC-Fr; Bovine, Human) [Full Text Article] [PubMed:26982592] [PMC:PMC4794180]

Cell-matrix signals specify bone endothelial cells during developmental osteogenesis. Langen UH, Pitulescu ME, Kim JM, Enriquez-Gasca R, Sivaraj KK, Kusumbe AP, Singh A, Di Russo J, Bixel MG, Zhou B, Sorokin L, Vaquerizas JM, Adams RH. Nature cell biology. 2017 March;19:189-201. (Mouse) [Full Text Article] [PubMed:28218908] [PMC:PMC5580829]

R-spondin-2 is a Wnt agonist that regulates osteoblast activity and bone mass. Knight MN, Karuppaiah K, Lowe M, Mohanty S, Zondervan RL, Bell S, Ahn J, Hankenson KD. Bone research. 2018 August;6:24. [Full Text Article] [PubMed:30131881] [PMC:PMC6089978]

Effects of dietary supplementation of arginine-silicate-inositol complex on absorption and metabolism of calcium of laying hens. Kazim Sahin, Cemal Orhan, Mehmet Tuzcu, Armagan Hayirli, James R Komorowski, Nurhan Sahin. PloS one. 2018 January;13:e0189329. [Full Text Article] [PubMed:29360830] [PMC:PMC5779645]

PGC-1a Controls Skeletal Stem Cell Fate and Bone-Fat Balance in Osteoporosis and Skeletal Aging by Inducing TAZ. Bo Yu, Lihong Huo, Yunsong Liu, Peng Deng, John Szymanski, Jiong Li, Xianghang Luo, Christine Hong, Jiandie Lin, Cun-Yu Wang. Cell stem cell. 2018 August;23:193-209.e5. [Full Text Article] [PubMed:30017591] [PMC:PMC6322535]

YAP1 and TAZ negatively control bone angiogenesis by limiting hypoxia-inducible factor signaling in endothelial cells. Kishor K Sivaraj, Backialakshmi Dharmalingam, Vishal Mohanakrishnan, Hyun-Woo Jeong, Katsuhiro Kato, Silke Schröder, Susanne Adams, Gou Young Koh, Ralf H Adams. eLife. 2020 Jan;9:e50770. [Full Text Article] [PubMed:31958058] [PMC:PMC6970532]

Albiflorin Promotes Osteoblast Differentiation and Healing of Rat Femoral Fractures Through Enhancing BMP-2/Smad and Wnt/ß-Catenin Signaling. Jae-Hyun Kim, Minsun Kim, SooYeon Hong, Eun-Young Kim, Hyangsook Lee, Hyuk-Sang Jung, Youngjoo Sohn. Frontiers in pharmacology. 2021 Jul;12:690113. [Full Text Article] [PubMed:34349649] [PMC:PMC8327266]

Induction of osteogenesis by bone-targeted Notch activation. Cong Xu , Van Vuong Dinh , Kai Kruse, Hyun-Woo Jeong, Emma C Watson, Susanne Adams, Frank Berkenfeld, Martin Stehling, Seyed Javad Rasouli, Rui Fan, Rui Chen, Ivan Bedzhov, Qi Chen, Katsuhiro Kato, Mara E Pitulescu, Ralf H Adams. eLife. 2022 February;11:e60183. [Full Text Article] [PubMed:35119364] [PMC:PMC8880996]

Regional specialization and fate specification of bone stromal cells in skeletal development. Kishor K Sivaraj, Hyun-Woo Jeong, Backialakshmi Dharmalingam, Dagmar Zeuschner, Susanne Adams, Michael Potente, Ralf H Adams. Cell reports. 2021 July;36:109352. [Full Text Article] [PubMed:34260921] [PMC:PMC8293626]

Schnurri-3 inhibition suppresses bone and joint damage in models of rheumatoid arthritis. Zheni Stavre, Jung-Min Kim, Yeon-Suk Yang, Kerstin Nündel, Sachin Chaugule, Tadatoshi Sato, Kwang Hwan Park, Guangping Gao, Ellen M Gravallese, Jae-Hyuck Shim. Proceedings of the National Academy of Sciences of the United States of America. 2023 May;120:e2218019120. [Full Text Article] [PubMed:37141171] [PMC:PMC10175794]

Adult alcohol drinking and emotional tone are mediated by neutral sphingomyelinase during development in males. Liubov S Kalinichenko, Christiane Mühle, Tianye Jia, Felix Anderheiden, Maria Datz, Anna-Lisa Eberle, Volker Eulenburg, Jonas Granzow, Martin Hofer, Julia Hohenschild, Sabine E Huber, Stefanie Kämpf, Georgios Kogias, Laura Lacatusu, Charlotte Lugmair, Stephen Mbu Taku, Doris Meixner, Nina-Kristin Sembritzki, Marc Praetner, Cosima Rhein, Christina Sauer, Jessica Scholz, Franziska Ulrich, Florian Valenta, Esther Weigand, Markus Werner, Nicole Tay, Conor J Mc Veigh, Jana Haase, An-Li Wang, Laila Ab. Cerebral cortex (New York, N.Y. : 1991). 2023 January;33:844-864. [Full Text Article] [PubMed:35296883]

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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