Target
Human Osteocalcin
Synonyms
BGLAP | Bone Gla protein | BGP | OC | Osteocalcin
Reactivity
Human
(tested or 100% immunogen sequence identity)
Immunogen
Recombinant human osteocalcin GST fusion protein.
Specificity
recognizes intact human and bovine osteocalcin in a "2 site" assay and reacts with osteocalcin fragments corresponding to amino acids 15-31 and 20-43 of the native molecule. It does not recognize fragments representing amino acids 1-19 or 7-19. Osteocalcin (Bone Gla Protein) is a 49 amino acid single chain vitamin K dependent protein (MW 5.8 kD), made by osteoblasts that is a major component of the non-collagenous bone matrix. Serum osteocalcin is elevated in diseases characterized by increased bone turnover such as osteoporosis, hyperparathyroidism and Pageta€™s disease, and low in conditions associated with low bone turnover such as hypoparathyroidism and growth hormone deficiency.