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NRSF / REST

RE1-silencing transcription factor

Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression.

Gene Name: RE1-silencing transcription factor
Synonyms: REST, X2 box repressor, XBR, NRSF
Target Sequences: NM_005612 NP_005603.3 Q13127

Publications (1)

1
The Rare YAP1 Subtype of SCLC Revisited in a Biobank of 39 Circulating Tumor Cell Patient Derived Explant Models: A Brief Report. Sarah M Pearsall, Sam Humphrey, Mitchell Revill, Derrick Morgan, Kristopher K Frese, Melanie Galvin, Alastair Kerr, Mathew Carter, Lynsey Priest, Fiona Blackhall, Kathryn L Simpson, Caroline Dive. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2020 December;15:1836-1843. (WB) [Full Text Article] [PubMed:32721553] [PMC:PMC7718082] Related Antibodies: LS-C668231.

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Products
Antibodies (36)
Primary (36)
NRSF / REST (36)
Human (35)
Mouse (10)
Rat (10)
Bat (3)
Bovine (3)
Chimpanzee (3)
Dog (3)
Gibbon (6)
Guinea pig (3)
Horse (3)
Monkey (6)
Pig (3)
Rabbit (3)
IHC (5)
IHC-P (4)
WB (27)
ELISA (7)
IF (4)
IP (3)
Peptide-ELISA (2)
rabbit (35)
goat (1)
IgG (24)
polyclonal pc (36)
APC Conjugated (2)
Azide-free (1)
Biotin Conjugated (5)
FITC Conjugated (5)
HRP Conjugated (5)
PE Conjugated (2)
Unconjugated (17)
aa542-570 (7)
aa20-69 (4)
aa972-1021 (4)
aa1050-C-term (2)
C-Terminus (1)
Internal Region (1)
aa800-850 (1)
aa801-1097 (1)
No (35)
Yes (1)
NRSF / REST Antibody - Western blot analysis of REST expression in MCF7 (A), HL60 (B) whole cell lysates.
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NRSF / REST Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
50 µl/$286; 100 µl/$321
NRSF / REST Antibody - Detection of Human REST by Immunohistochemistry. Sample: FFPE section of human metastatic lymph node. Antibody: Affinity purified rabbit anti-REST used at a dilution of 1:1000 (1 ug/ml). Detection: DAB.
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NRSF / REST Rabbit anti-Human Polyclonal (aa1050-C-term) Antibody
Human
IHC, IHC-P, WB
Unconjugated
10 µl/$295; 100 µl/$514
NRSF / REST Antibody - Detection of Human REST by Immunohistochemistry. Sample: FFPE section of human mucinous ovarian carcinoma. Antibody: Affinity purified rabbit anti-REST used at a dilution of 1:250.
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NRSF / REST Rabbit anti-Human Polyclonal (aa1050-C-term) Antibody
Human
IHC, IHC-P
Unconjugated
2.5 µg/$295; 100 µl/$532
NRSF / REST Antibody - REST antibody Western blot of Mouse Heart lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NRSF / REST Rabbit anti-Mouse Polyclonal (aa20-69) Antibody
Mouse
WB
Unconjugated
100 µl/$424
NRSF / REST Antibody - REST antibody Western blot of Mouse Heart lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NRSF / REST Rabbit anti-Mouse Polyclonal (aa20-69) (HRP) Antibody
Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Horse, Bat, Gibbon, Human, Monkey
WB
HRP Conjugated
100 µl/$469
NRSF / REST Antibody - REST antibody Western blot of Mouse Heart lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NRSF / REST Rabbit anti-Mouse Polyclonal (aa20-69) (Biotin) Antibody
Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Horse, Bat, Gibbon, Human, Monkey
WB
Biotin Conjugated
100 µl/$469
NRSF / REST Antibody - REST antibody Western blot of Mouse Heart lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NRSF / REST Rabbit anti-Mouse Polyclonal (aa20-69) (FITC) Antibody
Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Horse, Bat, Gibbon, Human, Monkey
WB
FITC Conjugated
100 µl/$469
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NRSF / REST Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IF, IHC, IHC-P, IP, WB
Unconjugated
100 µg/$830
NRSF / REST Antibody - Detection of Human REST by Immunohistochemistry. Sample: FFPE section of human metastatic lymph node. Antibody: Affinity purified rabbit anti-REST used at a dilution of 1:1000 (1 ug/ml). Detection: DAB.
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NRSF / REST Rabbit anti-Human Polyclonal (aa800-850) Antibody
Human
IHC, IHC-P, IP
Unconjugated
10 µg/$295; 100 µl/$514
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NRSF / REST Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IP, WB
Unconjugated
100 µg/$351
NRSF / REST Antibody - Immunohistochemistry of paraffin-embedded Human ovarian cancer tissue  using REST Polyclonal Antibody at dilution of 1:50(×200)
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NRSF / REST Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
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NRSF / REST Rabbit anti-Human Polyclonal Antibody
Human
IF
Unconjugated
20 µl/$275; 100 µl/$389
Select
NRSF / REST Rabbit anti-Human Polyclonal Antibody
Human
IF
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
NRSF / REST Antibody - Western blot analysis of REST using COLO205 whole lysates.
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NRSF / REST Rabbit anti-Human Polyclonal Antibody
Rat, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
NRSF / REST Antibody - Immunofluorescent analysis of HepG2 cells at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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NRSF / REST Rabbit anti-Human Polyclonal Antibody
Human
IF
Unconjugated
50 µg/$294; 100 µg/$360
NRSF / REST Antibody - Antibody (0.3µg/ml) staining of HEK293 (A) and HeLa (B) lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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NRSF / REST Goat anti-Human Polyclonal (Internal Region) Antibody
Human
Peptide-ELISA, WB
Unconjugated
100 µg/$503
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NRSF / REST Rabbit anti-Human Polyclonal (aa801-1097) Antibody
Mouse, Rat, Human
WB
Unconjugated
200 µg/$809
Select
NRSF / REST Rabbit anti-Human Polyclonal (aa542-570) Antibody
Human
WB
Unconjugated
200 µl/$734
Select
NRSF / REST Rabbit anti-Human Polyclonal (aa542-570) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
Select
NRSF / REST Rabbit anti-Human Polyclonal (aa542-570) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
Select
NRSF / REST Rabbit anti-Human Polyclonal (aa542-570) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
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NRSF / REST Rabbit anti-Human Polyclonal (aa542-570) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
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NRSF / REST Rabbit anti-Human Polyclonal (aa542-570) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
NRSF / REST Antibody - REST antibody Western blot of MCF7 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NRSF / REST Rabbit anti-Human Polyclonal (aa972-1021) Antibody
Human
WB
Unconjugated
100 µl/$424
NRSF / REST Antibody - REST Antibody western blot of Jurkat cell line lysates (35 ug/lane). The REST antibody detected the REST protein (arrow).
Select
NRSF / REST Rabbit anti-Human Polyclonal (aa542-570) Antibody
Human
WB
Unconjugated
400 µl/$393
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).